Substituted N-phenylmethyl -5-oxo-proline-2-amides as P2X7-receptor antagonists and their methods of use
15-03-2012 дата публикации
Номер:
AU2007271182B2
Автор: WALTER DARYL SIMON, CHAMBERS LAURA J, SENGER STEFAN, GLEAVE ROBERT, WALTER, DARYL SIMON, CHAMBERS, LAURA J, SENGER, STEFAN, GLEAVE, ROBERT
Принадлежит: Glaxo Group Ltd
Контакты:
Номер заявки: 11-27-200782
Дата заявки: 03-07-2007
The present invention relates to novel oxo-prolinamide derivatives of formula (I) which modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor and the use of such compounds or pharmaceutical compositions thereof in the treatment of disorders mediated by the P2X7 receptor, for example pain, inflammation and neurodegeneration.