METHODS AND COMPOSITIONS FOR TREATING CHRONIC INFLAMMATORY INJURY, METAPLASIA, DYSPLASIA AND CANCERS OF EPITHELIAL TISSUES
29-10-2020 дата публикации
Номер:
CA3135020A1
Автор: MCKEON FRANK, DULEBA MARCIN, ZHANG YANTING, XIE JINGZHONG, XIAN WA, VINCENT MATTHEW, MCKEON, FRANK, DULEBA, MARCIN, ZHANG, YANTING, XIE, JINGZHONG, XIAN, WA, VINCENT, MATTHEW
Принадлежит: DULEBA Marcin, Xie Jingzhong
Контакты:
Номер заявки: 3135020
Дата заявки: 24-04-2020
The present disclosure provides methods and formulations for treating a patient suffering from one or more of chronic inflammatory injury, metaplasia, dysplasia or cancer of an epithelial tissue, which method comprises administering to the patient an agent that selectively kills or inhibits the proliferation or differentiation of pathogenic epithelial stem cells (PESCs) relative to normal epithelial stem cells in the tissue in which the PESCs are found. Representative epithelial tissues include pulmonary, genitourinary, gastrointestinal/esophageal, pancreatic and hepatic tissues.