GROUP 8 TRANSITION METAL CATALYSTS AND METHOD FOR MAKING SAME AND PROCESS FOR USE OF SAME IN METATHESIS REACTION

This invention relates to Group 8 transition metal catalysts and method for making same and process for use of same in metathesis reaction.

Olefin metathesis is a catalytic process including, as a key step, a reaction between a first olefin and a first transition metal alkylidene complex, thus producing an unstable intermediate metallocyclobutane ring which then undergoes transformation into a second olefin and a second transition metal alkylidene complex according to equation (1) hereunder. Reactions of this kind are reversible and in competition with one another, so the overall result heavily depends on their respective rates and, when formation of volatile or insoluble products occurs, displacement of equilibrium.

Metathesis reactions are extensively applied in the field of chemical reactions, e.g. Ring closing metathesis (RCM), Cross metathesis (CM), Ring opening metathesis (ROM), Ring opening metathesis polymerization (ROMP), acyclic diene metathesis (ADMET), self-metathesis, conversion of olefins with alkynes (enyne metathesis), polymerization of alkynes, and so on.

Typical applications of olefin metathesis but not limited are Reaction Injection Molding (RIM), filament winding, pultrusion of dicyclopentadiene (DCPD), which is an example of the ring opening metathesis polymerization. Industrial application in DCPD polymerization requires latent catalysts, which can allow for longer handling of a monomer-catalyst mixture before the polymerization starts. Other examples of ring opening metathesis polymerization are ROMP of norbornene and its derivatives, copolymerization of different cyclic olefins. Ethenolysis, a chemical process in which internal olefins are degraded using ethylene as the reagent, is an example of cross metathesis; CM of ethene with 2-butene; depolymerization of unsaturated polymers and so fort.

Although homo-coupling (equation 3a) is of high interest, the same is true for cross-coupling between two different terminal olefins (equation 3b). Coupling reactions involving dienes lead to linear and cyclic dimers, oligomers, and, ultimately, linear or cyclic polymers (equation 6). In general, the latter reaction is favoured in highly concentrated solutions or in bulk, while cyclisation is favoured at low concentrations. When intra-molecular coupling of a diene occurs so as to produce a cyclic alkene, the process is called ring-closing metathesis (equation 2). Cyclic olefins can be opened and oligomerised or polymerised (ring opening metathesis polymerisation shown in equation 5). When the alkylidene catalyst reacts more rapidly with the cyclic olefin (e.g. a norbornene or a cyclobutene) than with a carbon-carbon double bond in the growing polymer chain, then a “living ring opening metathesis polymerisation” may result, i.e. there is little termination during or after the polymerization reaction. Strained rings may be opened using an alkylidene catalyst with a second alkene following the mechanisms of the Cross Metathesis. The driving force is the relief of ring strain. As the products contain terminal vinyl groups, further reactions of the Cross Metathesis variety may occur. Therefore, the reaction conditions (time, concentrations, . . . ) must be optimized to favour the desired product (equation 4). The enyne metathesis is a metalcarbene-catalysed bond reorganization reaction between alkynes and alkenes to produce 1,3-dienes. The intermolecular process is called Cross-Enyne Metathesis (7), whereas intramolecular reactions are referred as Ring-Closing Enyne Metathesis (RCEYM).

The cross-metathesis of two reactant olefins, where each reactant olefin comprises at least one unsaturation site, to produce new olefins, which are different from the reactant olefins, is of significant commercial importance. One or more catalytic metals, usually one or more transition metals, usually catalyse the cross-metathesis reaction.

One such commercially significant application is the cross-metathesis of ethylene and internal olefins to produce alpha-olefins, which is generally referred to as ethenolysis. More specific, the cross-metathesis of ethylene and an internal olefin to produce linear α-olefins is of particular commercial importance. Linear α-olefins are useful as monomers or co-monomers in certain (co)polymers poly α-olefins and/or as intermediates in the production of epoxides, amines, oxo alcohols, synthetic lubricants, synthetic fatty acids and alkylated aromatics. Olefins Conversion Technology™, based upon the Phillips Triolefin Process, is an example of an ethenolysis reaction converting ethylene and 2-butene into propylene. These processes apply heterogeneous catalysts based on tungsten and rheniumoxides, which have not proven effective for internal olefins containing functional groups such as cis-methyl oleate, a fatty acid methyl ester.

1-Decene is a co-product typically produced in the cross-metathesis of ethylene and methyl oleate. Alkyl oleates are fatty acid esters that can be major components in biodiesel produced by the transesterification of alcohol and vegetable oils. Vegetable oils containing at least one site of unsaturation include canola, soybean, palm, peanut, mustard, sunflower, tung, tall, perilla, grapeseed, rapeseed, linseed, safflower, pumpkin, corn and many other oils extracted from plant seeds. Alkyl erucates similarly are fatty acid esters that can be major components in biodiesel. Useful biodiesel compositions are those, which typically have high concentrations of oleate and erucate esters. These fatty acid esters preferably have one site of unsaturation such that cross-metathesis with ethylene yields 1-decene as a co-product.

Vegetables oils used in food preparation (fritting of meat, vegetables, . . . ) can be recuperated and after purification, be converted applying e.g. ethenolysis into useful products applicable in biodiesel.

Biodiesel is a fuel prepared from renewable sources, such as plant oils or animal fats. To produce biodiesel, triacylglycerides, the major compound in plant oils and animal fats, are converted to fatty acid alkyl esters (i.e., biodiesel) and glycerol via reaction with an alcohol in the presence of a base, acid, or enzyme catalyst. Biodiesel fuel can be used in diesel engines, either alone or in a blend with petroleum-based diesel, or can be further modified to produce other chemical products.

Several metal-carbene complexes are known for olefin metathesis however the difference between those structures can be found in the carbene part. Patents WO-A-96/04289 and WO-A-97/06185 are examples of metathesis catalysts having the general structure

Where:

M is Os or Ru, R and R¹organic parts from the carbene fragment which have a great structural variability, X and X₁are anionic ligands and L and L₁represents neutral electron donors. “Anionic ligands” are, according the literature in the field of olefin metathesis catalysts, ligands which are negative charged and thus bearing a full electron shell when they are removed from the metal center

A well-known example of this class of compounds is the Grubbs 1^stgeneration catalysts

Another well-known example of this class of compounds is the Grubbs' 2^ndgeneration catalyst which is described in WO-A-0071554 and the hexa-coordinated “Grubbs 3^rdgeneration catalyst described in WO-A03/011455.

There are still some other well-known catalysts described in literature which are very useful in the area of olefin metathesis, and which serve as background information for this application.

Furthermore, other catalysts are known where both carbon atoms of the carbene fragment are bridged; a few of these representatives are given:

The bridged carbene fragment was firstly synthesized by Hill et al. (K. J. Harlow, A. F. Hill, J. D. E. T. Wilton-Ety, J. Chem. Soc. Dalton Trans. 1999, 285-291), however the structure was wrongly interpreted. Fürstner et al. corrected this misinterpretation (J. Org. Chem. 1999, 64, 8275-8280) and a full characterization was described. It followed that reorganization takes place whereby the carbon atoms of the carbene fragment are bridged and generating in this specific case a “3-phenyl-indenylidene carbene” (Chem. Eur. J. 2001, 7, No 22, 4811-4820). Analogues of this catalyst bearing one NHC-ligand and one phosphine ligand where described by Nolan in WO-A-00/15339. These types of compounds are not only catalysts for the olefin metathesis; they also can be used as starting product to produce other ruthenium-carbene compounds via cross metathesis (WO-A-2004/112951).

Furthermore, in US-A-2003/0100776 on page 8, paragraph are catalysts described where the carbon atoms of the carbene part are bridged and whereby the newly formed cyclic group can be aliphatic or aromatic and can bear substituents or hetero atoms. Additionally, it is said that the generated ring structure is constructed of 4 to 12 and preferable 5 to 8 atoms contains. However, no explicit ring structures or examples are described or given.

For some processes it is desirable that catalyst initiation be controllable. Much less work has focused on decreasing the initiation rate of ruthenium-based catalysts. In these cases, the use of a trigger such as light activation (e.g. photoirradiation), chemical activation (e.g. acid addition), temperature activation (e.g. heating of the sample) or mechanical activation (e.g. ultrason) can help to control initiation. Efficient ring-opening metathesis polymerization (ROMP) reactions require adequate mixing of monomer and catalyst before polymerization occurs. For these applications, catalysts that initiate polymerization at a high rate only upon activation are desirable. However, both Grubbs 2^ndgen and Hoveyda 2^ndgen. are competent metathesis catalysts at or below room temperature, so alone are not suited for applications where catalyst latency is beneficial (Org. Lett. 1999, 1, 953-956; J. Am. Chem. Soc. 2000, 122, 8168-8179; Tetrahedron Lett. 2000, 41, 9973-9976).

Experimental studies have shown that, for the majority of ruthenium catalysts, dissociation of a donor ligand provides entry to the catalytic cycle. Several design strategies for slowing ligand dissociation can be envisioned. An important consideration is that the method used to slow initiation should not disrupt the catalyst activity. The addition of excess phosphine to the reaction can serve to slow initiation as shown in case I (Scheme 1)(J. Am. Chem. Soc. 1997, 119, 3887-3897). Unfortunately the addition of phosphine commonly results in propagation rates also being reduced.

Another strategy to slow catalyst initiation is to replace the Schrock-type ruthenium carbene with a Fischer carbene (Type II, Scheme 1). This approach has been used to generate several latent metathesis catalysts with Fischer carbenes featuring oxygen, sulphur, and nitrogen substitution. (Organometallics 2002, 21, 2153-2164; J. Organomet. Chem. 2000, 606, 65-74). In some cases, the decrease in activity with these systems is so great that they are considered metathesis-inactive. In fact, addition of ethyl vinyl ether to form a Fischer carbene complex is a standard method of quenching ROMP reactions.

Van der Schaaf and co-workers followed another approach (type IV, scheme 1) to develop the temperature activated, slow initiating olefin metathesis catalyst (PR₃)(CI)₂Ru(CH(CH₂)₂—C,N-2-C₅H₄N) (1 in Scheme 2) in which initiation temperatures were tuned by changing the substitution pattern of the pyridine ring (J. Organomet. Chem. 2000, 606, 65-74). Unfortunately, activities of the reported complexes were undesirably low; restricted to 12000 equiv DCPD. Later, Ung reported on analogous tunable catalytic systems obtained by partially isomerizing trans-(SIMes)(CI)₂Ru(CH(CH₂)₂—C,N-2-C₅H₄N) (2 in scheme 2) into the cis analogue (Organometallics 2004, 23, 5399-5401). However, none of these catalysts allowed for storage in DCPD monomer for long time as the ROMP of DCPD is completed in 25 minutes after catalyst introduction.

In another methodology towards rationally designed thermally stable olefin metathesis catalyst for DCPD polymerization, efforts were directed towards the development of an O,N-bidentate Schiff base ligated Ru-carbene catalysts elaborated by Grubbs (U.S. Pat. No. 5,977,393; Scheme 3, 4 wherein L=PR₃) and Verpoort (WO 03/062253; Scheme 3, 4 wherein L=SIMes and 5 wherein L=PR₃, SIMes). It was shown that such complexes are extremely inactive at room temperature towards the polymerization of low-strain, cyclic olefins, allow for storage in DCPD for months and can be thermally activated to yield increased activity for the bulk-polymerization of DCPD, but from industrial point of view, catalysts of which their performance is easy tunable by a simple straightforward modification are not described (EP1468004; J. Mol. Cat. A: Chem. 2006, 260, 221-226).

Recently a series of latent olefin metathesis catalysts bearing bidentate K²—(O,O) ligands were synthesized (Scheme 3, 3). Complex 3, proved to be inactive for the solvent-free polymerization of DCPD. It was furthermore illustrated that complex 3 (Scheme 3, L=PCy₃, SIMes) is readily activated upon irradiation of a catalyst/monomer mixture containing a photoacid generator and was found applicable in ROMP of DCPD (WO 99/22865). Nevertheless irradiation of a solution of DCPD and 3 (L=SlMes) in a minimal amount of CH₂CI₂resulted in complete gelation within 1 h but solidified and cross-linked monomer was not obtained.

This indicates low catalyst activity and the operation on a low amount of the active species. Summarizing, the latent catalysts are of prominent importance for Ring-Opening Metathesis Polymerizations of low-strained cyclic olefins, as they allow for mixing of monomer and catalyst without concomitant gelation or microencapsulation of the precatalyst.

All the above-described catalysts bearing an indenylidene carbene part are based on a non-chelating phenyl-indenylidene structure without any substituents or functional groups. Catalysts with a chelating phenyl-indenylidene structure have been described in PCT/US2010/059703 (WO 2011/100022 A2) an indenylidene based catalyst is described whereby one phosphine ligand is substituted by a neutral donor ligand which is linked to the indenylidene carbene. The resulting catalyst is a 3-phenylindenylidene Hoveyda analogue catalyst.

In PCT/US2011/029690 (WO 2011/119778 A2) a hexa-coordinated catalyst is claimed, however in this document no catalysts were isolated; a synthetic method for the in-situ generation of olefin metathesis catalysts is disclosed since according to Schrödi the synthesis of these complexes is relatively cumbersome. The synthesis usually involves more than one step and requires isolation of the catalysts to remove catalyst-inhibiting byproducts such as liberated phosphines. The resulting in-situ generated catalysts are all phenylindenylidene Hoveyda analogue catalysts.

Other non-chelating indenylidene catalysts bearing functional groups or substituents on the indenylidene part, different from phenylindenylidene, are until now not known.

In WO 2011/009721 A1 bis-Schiff base catalysts are described on page 18-20 “via route B” starting from 5 with L=SIMes wherein it is said that the reaction mixture was investigated with¹H and³¹P NMR revealing a quantitative transformation to the desired bis-Schiff Base catalyst. However, none of those compounds contain any P-ligand. Furthermore, the catalysts prepared via “route A” were investigated with¹H and³¹P NMR revealing a quantitative transformation to the desired bis-Schiff Base catalyst, though, no values are given.

Moreover, it is said that the bis-Schiff base catalyst (catalyst 4 on page 22) has an extreme latent character even at 200° C. (catalyst 4/DCPD ratio: 1/15000) as was proven with DSC. However, it is well-know that DCPD when heated above 150° C., undergoes a retro-Diels-Alder reaction to yield cyclopentadiene and the boiling point is 170° C.

Additionally, it is said in the “summary of the invention” page 4 that the catalysts are obtained by a simple, efficient, green and highly yielding synthetic process. However, the catalysts procedure for the catalysts synthesis is 72 h (without purification steps) which can not be called “efficient” or industrial attractive. Besides of all the synthesized catalysts no yield is mentioned.

The ruthenium carbene part (indenylidene) in WO 2011/009721 A1 is defined as in WO 00/15339. The most preferably carbene part is a phenylindenylidene ligand. Yet, no substituted phenylindenylidene ligands are claimed.

Despite the advances achieved in the preparation and development of olefin metathesis catalysts, a continuing need exists for new improved synthetic methods and new catalysts. Of particular interest are methods that provide the preparation of new catalysts, which easily can be prepared on industrial scale.

Notwithstanding the different available catalysts, from industrial point of view, catalysts of which their performance is easy tunable by a simple straightforward modification are highly desired. Of particular interest are catalysts which can be modified from completely latent to highly active; latent catalysts find easily application in ROMP e.g. DCPD polymerization via RIM, highly active catalysts find easily application in cross metathesis e.g. ethenolysis.

Moreover, easy tunable catalysts can be obtained by tuning of the electron density of the catalyst by variation of the alkylidene (e.g. indenylidene) in combination with ligands (e.g. ditopic or multitopic ligands). However, the combination of non-chelating substituted/functionalised indenylidene with ditopic or multitopic ligands is still not existing and offers extra advantage in terms of initiation tunability which results in catalysts which can be varied from real latent to highly active.

Additionally, the catalysts of present invention afford latent catalysts stable in the monomer and highly active after an industrially acceptable activation process, a property of which there is still a high demand.

Furthermore, the instant invention's metathesis catalyst compounds provide both a mild and commercially economical and an “atom-economical” route to desirable olefins, which in turn may be useful in the preparation of linear alpha-olefins, unsaturated polymers, cyclic olefins, etc. . . . .

Another important parameter for the evaluation of metathesis catalysts is the need for catalysts that can be separated from the final metathesis product easily. For applications of metathesis reactions in pharmaceutical industry, the ruthenium level in drugs must not exceed 5 ppm. (http://www.emea.europa.eu/pdfs/human/swp/444600en.pdf for EMEA regulations) Up to date, different protocols were reported to remove ruthenium from metathesis products to meet these criteria. The employed protocols include removal of ruthenium by oxidation reactions (H₂O₂, PPh₃O, DMSO or Pb(OAc)₄, water extraction, scavengers, supported phosphine ligands, or treatment with active charcoal combined with chromatography. These protocols only decreased the ruthenium concentration in the final product to 100-1200 ppm, which is far from the required criteria for pharmaceutical applications. The immobilization of catalysts (organic or inorganic support) gave promising results with moderate success for efficient removal of ruthenium. As another strategy, modification of the ligands by more polar groups or alternation of their steric hindrance to ease their separation from metathesis products was also reported. Grela successfully modified Hoveyda-Grubbs type catalysts with ionic-tagged ligands which exhibits a good affinity towards silica gel. (Green Chem., 2012, 14, 3264.) However, the synthesis of an ionic-tagged ligand is cumbersome. The catalysts of this invention, obtained via a straightforward synthesis procedure, show an extremely high affinity for silica especially catalysts bearing multitopic ligands making them extremely useful and attractive for pharmaceutical and fine chemical applications.

The synthesis of RuCl₂(PCy₃)₂(3-phenylindenylidene) has proven useful in providing an easy route to ruthenium alkylidenes which avoids costly diazo preparations (Platinum Metals Rev. 2005, 49, 33).

In order to obtain an economically viable process for linear α-olefins (e.g. 1-decene) production via the cross-metathesis of ethylene and biodiesel (such as animal or vegetable oils), higher activity catalysts or more stable catalysts must be developed. Moreover, there is still a need for the development of catalysts with equivalent or better performance characteristics but synthesized directly from less expensive and readily available starting materials.

As there is a continuous need in the art for improving catalyst efficiency, i.e. improving the yield of the reaction catalysed by the said catalyst component after a certain period of time under given conditions (e.g. temperature, pressure, solvent and reactant/catalyst ratio) or else, at a given reaction yield, providing milder conditions (lower temperature, pressure closer to atmospheric pressure, easier separation and purification of product from the reaction mixture) or requiring a smaller amount of catalyst (i.e. a higher reactant/catalyst ratio) and thus resulting in more economic and environment-friendly operating conditions. This need is still more stringent for use in reaction-injection molding (RIM) processes such as, but not limited to, the bulk polymerisation of endo- or exo-dicyclopentadiene, or formulations thereof.

There is also a specific need in the art, which is yet another goal of this invention, for improving reaction-injection molding (RIM) processes, resin transfer molding (RTM) processes and reactive rotational molding (RRM) processes such as, but not limited to, the bulk polymerisation of endo- or exo-dicyclopentadiene, or copolymerization thereof with other monomers, or formulations thereof. More specifically there is a need to improve such processes which are performed in the presence of multicoordinated transition metal complexes, in particular ruthenium complexes. All the above needs constitute the various goals to be achieved by the present invention; nevertheless other advantages of this invention will readily appear from the following description.

The present invention is directed to addressing one or more of the above-mentioned issues. The invention is based on the unexpected finding that improved metathesis of unsaturated compounds such as olefins and alkynes can be obtained by catalysts having a general structure of formula (I-II) and (VII) by modifying the alkylidene part of group 8 catalysts of the prior art in combination with a ditopic or multitopic ligand(s).

The present invention provides catalysts which can be easily and efficiently activated by a chemical activator (Brönsted and Lewis acids) or a photo-activator (Photo acid generator, PAG) showing exceptional activity after activation. The catalysts of present invention can also be activated by in-situ generation of a Brønsted acid by combining a Lewis acid, which at least contains one halogen atom, with any —OH or —SH containing molecule(s) (liquid or solid, organic or inorganic).

In a preferred embodiment of the invention, unsaturated carboxylic acids and/or esters of unsaturated carboxylic acids individually and/or mixtures of the unsaturated carboxylic acids or mixtures of esters of unsaturated carboxylic acids can be converted. The catalysts of this invention are preferably used in concentrations of less than or equal to 1000 ppm, in particular in the range from 1 to 1000 ppm, preferably 5 to 200 ppm. The inventive method can be carried out at temperatures between 0 to 100° C., preferably between 20 to 90° C., are carried out in particular between 40 to 80° C.

The method can be performed using conventional solvents, in which the reactant(s) and the catalyst are dissolved, e.g. hydrocarbons or alcohols. In a preferred embodiment of the invention the method may be carried out solventless.

Via this inventive method unsaturated α,ω dicarboxylic acids and unsaturated α,ω dicarboxylic acid diesters are obtained together with the corresponding unsaturated hydrocarbons. A separation of the mixture can be done, for example, by distillation, by fractionated crystallization or by extraction. These products produced by the inventive method unsaturated α,ω dicarboxylic acids and unsaturated α,ω dicarboxylic acid diester can be used in e.g. cosmetic preparations. If necessary, the products thus obtained can be subjected to hydrogenation.

The present invention is also based on the unexpected finding that the synthesis time of the organometallic compounds of formula (I-II) and (VII) can be reduced to 4 hours or less while maintaining high to excellent yields.

The organometallic catalyst compounds of the present invention can be prepared by contacting a Group 8 metal precursor compound with at least one ditopic ligand which alternatively can bear at least an extra chelating moiety.

Wherein,

M is a Group 8 metal, preferably ruthenium or osmium;

R¹-R⁶are identical or different and selected from H, hydrocarbyl, substituted hydrocarbyl, heteroatom containing hydrocarbyl, substituted heteroatom-containing hydrocarbyl, and functional groups, except that R²does not represent phenyl when R¹═R³═R⁴═R⁵═R⁶═H;

wherein alternatively in each case two directly adjacent radicals from the group of R¹-R⁶, including the ring carbon atoms to which they are attached by a cyclic bridging group, generating one or more cyclic structures, including aromatic structures;

X¹preferably represents an anionic ligand;

L¹preferably represents a neutral electron donor;

L¹and X¹may be joined to form a multidentate monoanionic group and may form single ring of up to 30 non-hydrogen atoms or a multinuclear ring system of up to 30 non-hydrogen atoms;

A¹-A²are identical or different and are selected from the group consisting of oxygen, sulphur, selenium, NR″″, PR″″, POR″″, AsR″″, AsOR″″, SbOR″″ and SbR″″;

T¹-T²are identical or different and are selected from the group consisting of:

wherein E preferably represents a donor atom selected from the group consisting of nitrogen, phosphor, oxygen, sulphur, and selenium; wherein for the group

in case of oxygen, sulphur and selenium, R is omitted for double bonded E or R remains for a single bonded E; wherein for the group

in case of oxygen, sulphur and selenium, the E-C bound is a single bond and the C atom contains an extra R group or the C—R′ is a double bond or the C—R is a double bond.

R, R′, R″, R′″ and R″″ are identical or different and selected from H, hydrocarbyl, substituted hydrocarbyl, heteroatom containing hydrocarbyl, substituted heteroatom-containing hydrocarbyl, and functional groups;

wherein alternatively in each case two directly adjacent radicals from the group of R, R′, R″, R′″ and R″″, including the carbon atoms to which they are attached, generating one or more cyclic structures, including aromatic structures.

C¹-C²are carbon atoms linked to each other via a single or double bond wherein in case of a single bond each carbon atom bears an extra substituent R^C1and R^C2; R^C1and R^C2are identical or different and are as defined for R′, R″, R′″ and R″″.

In an extra aspect, the invention provides a method for performing a catalytic metathesis reaction comprising contacting at least one olefin or olefinic compound with the metathesis catalyst of the invention. An olefin includes a single olefin, multi-olefin as well as a combination or mixture of two or more olefins, reference to “a substituent” encompasses a single substituent as well as two or more substituents, and the like.

In a further aspect the present invention is based on the unexpected finding that superior catalysts (I-II, VII) useful in the metathesis of unsaturated compounds such as olefins and alkynes, their activity can even be extra enhanced by bringing into contact a metal complex (I-II, VII) with an activating compound (hereinafter also referred as “activator”) selected from Brønsted acids (Brønsted acids are proton donors, which is the commonly accepted practice among chemists). The nature of the Brønsted acid can be liquid, solid, inorganic or organic. Well-know representative compounds of Brønsted acids, but not limited, are HCl, HBr, H₂SO₄, CH₃COOH, sulphonic acid resins, etc.

In a further aspect the present invention is based on the unexpected finding that superior catalysts useful in the metathesis of unsaturated compounds such as olefins and alkynes can be obtained by bringing into contact a metal complex (I-II, VII) with an activating compound (hereinafter also referred as “activator”) selected from the group consisting of:

• • M^a(I) halides.
  • compounds represented by the formula M^aX_2-yR^a_y(0≦y≦2).

wherein

R^ais equal to R¹-R⁶defined as herein-above,

X is atom of the halogen group and identical or different in case more then one halogen atom is present, and

M^ais an atom having an atomic mass from 27 to 124 and being selected from the group consisting of groups IB, IIB, IIIA, IVB, IVA and VA of the Periodic Table of elements under conditions such that at least partial cleavage of a bond between the metal and the ditopic or multitopic ligand of said catalyst occurs.

• • compounds represented by the formula M^aX_3-yR^a_y(0≦y≦3) wherein R^a, X and M^adefined as herein-above.
  • compounds represented by the formula M^aX_4-yR^a_y(0≦y≦4) wherein R^a, X and M^adefined as herein-above.
  • compounds represented by the formula M^aX_5-yR^a_y(0≦y≦5) wherein R^a, X and M^adefined as herein-above.
  • compounds represented by the formula M^aX_6-yR^a_y(0≦y≦6) wherein R^a, X and M^adefined as herein-above.

In yet another specific embodiment, the present invention is based on the unexpected finding that useful catalytic species can be suitably obtained by reacting an activator such as defined hereinabove, provided that said activator includes at least one halogen atom, in the presence of at least one further reactant having the formula RYH, wherein Y is selected from the group consisting of oxygen, sulphur and selenium, and R as defined hereinabove. According to this specific embodiment, a strong acid (such as a hydrogen halide) may be formed in situ by the reaction of said activator, with said further reactant having the formula RYH, and said strong acid if produced in sufficient amount may in turn be able:

• • in a first step, to protonate the ditopic (or multitopic) ligand and decoordinate T¹(in case of structure (I)) or T¹or T²or both (in case of structure (II)) of said ditopic (or multitopic) ligand from the complexed metal, and
  • in a second step, to decoordinate the further heteroatom of said ditopic (or multitopic) ligand from the complexed metal.

In this specific embodiment, at least partial cleavage of a bond between the metal and the ditopic (or multitopic) ligand of said metal complex occurs like in the absence of the further reactant having the formula RYH, but coordination of T¹or T²or both atoms of the ditopic (or multitopic) ligand to the activator occurs less frequently because it competes unfavourably with the protonation/decoordination mechanism resulting from the in situ generation of a strong acid (such as a hydrogen halide). This alternative mechanism is however quite effective in the catalysis of metathesis reactions of olefins and alkynes since it provides a more random distribution of the strong acid in the reaction mixture than if the same strong acid is introduced directly in the presence of catalyst (I-II,VII).

The new catalytic species of the invention may be produced extra-temporaneously, separated, purified and conditioned for separate use in organic synthesis reactions later on, or they may be produced in situ during the relevant chemical reaction (e.g. metathesis of unsaturated organic compounds) by introducing a suitable amount of the activator into the reaction mixture before, simultaneously with, or alternatively after the introduction of the starting catalyst compound. The present invention also provides catalytic systems including, in addition to said new catalytic species or reaction products, a carrier suitable for supporting said catalytic species or reaction products.

The present invention also provides methods and processes involving the use of such new catalytic species or reaction products, or any mixture of such species, or such catalytic systems, in a wide range of organic synthesis reactions including the metathesis of unsaturated compounds such as olefins and alkynes and In particular, this invention provides an improved process for the ring opening polymerization of strained cyclic olefins such as, but not limited to, dicyclopentadiene.

In the context of this invention, all the above and below mentioned, general or preferred ranges of definitions, parameters or elucidations among one another, or also between the respective ranges and preferred ranges can be combined in any manner.

In the context of this invention, related to the different types of metathesis catalysts, the term “substituted” means that a hydrogen atom or an atom is replaced by a specified group or an atom, and the valence of the atom indicated is not exceeded and the substitution leads to a stable compound.

Unless otherwise mentioned, the invention is not limited to specific reactants, substituents, catalysts, reaction conditions, or the like, as such may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting.

In this specification and in the claims that follow, reference will be made to a number of terms, which shall be defined to have the following meanings:

The term “alkyl” as used herein refers to a linear, branched, or cyclic saturated hydrocarbon group typically although not necessarily containing 1 to about 24 carbon atoms, preferably 1 to about 12 carbon atoms, such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, t-butyl, octyl, decyl, and the like, as well as cycloalkyl groups such as cyclopentyl, cyclohexyl and the like. Generally, although again not necessarily, alkyl groups herein contain 1 to about 12 carbon atoms. The term “C₁-C₆-alkyl” intends an alkyl group of 1 to 6 carbon atoms, and the specific term “cycloalkyl” intends a cyclic alkyl group, typically having 3 to 8 carbon atoms.

The term “substituted alkyl” refers to alkyl substituted with one or more substituent groups, and the terms “heteroatom-containing alkyl” and “heteroalkyl” refer to alkyl in which at least one carbon atom is replaced with a heteroatom. If not otherwise indicated, the term “alkyl” includes linear, branched, cyclic, unsubstituted, substituted, and/or heteroatom-containing alkyl.

The term “alkylene” as used herein refers to a difunctional linear, branched, or cyclic alkyl group, where “alkyl” is as defined above.

The term “alkenyl” as used herein refers to a linear, branched, or cyclic hydrocarbon group of 2 to about 24 carbon atoms containing at least one double bond, such as ethenyl, n-propenyl, isopropenyl, n-butenyl, isobutenyl, octenyl, decenyl, tetradecenyl, hexadecenyl, eicosenyl, and the like. Preferred alkenyl groups herein contain 2 to about 12 carbon atoms. The term “cycloalkenyl” intends a cyclic alkenyl group, preferably having 5 to 8 carbon atoms. The term “substituted alkenyl” refers to alkenyl substituted with one or more substituent groups, and the terms “heteroatom-containing alkenyl” and “heteroalkenyl” refer to alkenyl in which at least one carbon atom is replaced with a heteroatom. If not otherwise indicated, the term “alkenyl” include linear, branched, cyclic, unsubstituted, substituted, and/or heteroatom-containing alkenyl.

The term “alkenylene” as used herein refers to a difunctional linear, branched, or cyclic alkenyl group, where “alkenyl” is as defined above.

The term “alkynyl” as used herein refers to a linear or branched hydrocarbon group of 2 to about 24 carbon atoms containing at least one triple bond, such as ethynyl, n-propynyl, and the like. Preferred alkynyl groups herein contain 2 to about 12 carbon atoms. The term “substituted alkynyl” refers to alkynyl substituted with one or more substituent groups, and the terms “heteroatom-containing alkynyl” and “heteroalkynyl” refer to alkynyl in which at least one carbon atom is replaced with a heteroatom. If not otherwise indicated, the term “alkynyl” include linear, branched, unsubstituted, substituted, and/or heteroatom-containing alkynyl respectively.

The term “alkoxy” as used herein intends an alkyl group bound through a single, terminal ether linkage; that is, an “alkoxy” group may be represented as —O-alkyl where alkyl is as defined above. Analogously, “alkenyloxy” refers to an alkenyl group bound through a single, terminal ether linkage, and “alkynyloxy” refers to an alkynyl group bound through a single, terminal ether linkage.

The term “aryl” as used herein, and unless otherwise specified, refers to an aromatic substituent containing a single aromatic ring or multiple aromatic rings that are fused together, directly linked, or indirectly linked (such that the different aromatic rings are bound to a common group such as a methylene or ethylene moiety). Preferred aryl groups contain 5 to 24 carbon atoms, and particularly preferred aryl groups contain 5 to 14 carbon atoms. Exemplary aryl groups contain one aromatic ring or two fused or linked aromatic rings, e.g., phenyl, naphthyl, biphenyl, diphenylether, diphenylamine, benzophenone, and the like. “Substituted aryl” refers to an aryl moiety substituted with one or more substituent groups, and the terms “heteroatom-containing aryl” and “heteroaryl” refer to aryl substituents in which at least one carbon atom is replaced with a heteroatom, as will be described in further detail infra.

The term “aryloxy” as used herein refers to an aryl group bound through a single, terminal ether linkage, wherein “aryl” is as defined above. An “aryloxy” group may be represented as —O-aryl where aryl is as defined above. Preferred aryloxy groups contain 5 to 24 carbon atoms, and particularly preferred aryloxy groups contain 5 to 14 carbon atoms. Examples of aryloxy groups include, without limitation, phenoxy, o-halo-phenoxy, m-halo-phenoxy, p-halo-phenoxy, o-methoxyphenoxy, m-methoxy-phenoxy, p-methoxy-phenoxy, 2,4-dimethoxy-phenoxy, 3,4,5-trimethoxy-phenoxy, and the like.

The term “alkaryl” refers to an aryl group with an alkyl substituent, and the term “aralkyl” refers to an alkyl group with an aryl substituent, wherein “aryl” and “alkyl” are as defined above. Preferred alkaryl and aralkyl groups contain 6 to 24 carbon atoms. Alkaryl groups include, but not limit to, for example, p-methylphenyl, 2,4-dimethylphenyl, p-cyclohexylphenyl, 2,7-dimethylnaphthyl, 7-cyclooctylnaphthyl, 3-ethyl-cyclopenta-1,4-diene, and the like. Examples of aralkyl groups include, without limitation, benzyl, 2-phenyl-ethyl, 3-phenyl-propyl, 4-phenyl-butyl, 5-phenyl-pentyl, 4-phenylcyclohexyl, 4-benzylcyclohexyl, 4-phenylcyclohexylmethyl, 4-benzylcyclohexylmethyl, and the like. The terms “alkaryloxy” and “aralkyloxy” refer to substituents of the formula —OR wherein R is alkaryl or aralkyl, respectively, as just defined.

The term “acyl” refers to substituents having the formula —(CO)-alkyl, —(CO)-aryl, or —(CO)-aralkyl, and the term “acyloxy” refers to substituents having the formula —O(CO)-alkyl, —O(CO)aryl, or —O(CO)-aralkyl, wherein “alkyl,” “aryl, and “aralkyl” are as defined above.

The terms “cyclic” and “ring” refer to alicyclic or aromatic groups that may or may not be substituted and/or heteroatom containing, and that may be monocyclic, bicyclic, or polycyclic. The term “alicyclic” is used in the conventional sense to refer to an aliphatic cyclic moiety, as opposed to an aromatic cyclic moiety, and may be monocyclic, bicyclic, or polycyclic.

The terms “halo” and “halogen” are used in the conventional sense to refer to a chloro, bromo, fluoro, or iodo substituent.

“Hydrocarbyl” refers to univalent hydrocarbyl radicals containing 1 to about 30 carbon atoms, preferably 1 to about 24 carbon atoms, most preferably 1 to about 12 carbon atoms, including linear, branched, cyclic, saturated, and unsaturated species, such as alkyl groups, alkenyl groups, aryl groups, and the like. The term “hydrocarbylene” intends a divalent hydrocarbyl moiety containing 1 to about 30 carbon atoms, preferably 1 to about 24 carbon atoms, most preferably 1 to about 12 carbon atoms, including linear, branched, cyclic, saturated and unsaturated species. “Substituted hydrocarbyl” refers to hydrocarbyl substituted with one or more substituent groups, and the terms “heteroatom-containing hydrocarbyl” and “heterohydrocarbyl” refer to hydrocarbyl in which at least one carbon atom is replaced with a heteroatom. Similarly, “substituted hydrocarbylene” refers to hydrocarbylene substituted with one or more substituent groups, and the terms “heteroatom containing hydrocarbylene” and “heterohydrocarbylene” refer to hydrocarbylene in which at least one carbon atom is replaced with a heteroatom. Unless otherwise indicated, the term “hydrocarbyl” and “hydrocarbylene” are to be interpreted as including substituted and/or heteroatom-containing hydrocarbyl and hydrocarbylene moieties, respectively.

The term “heteroatom-containing” as in a “heteroatom-containing hydrocarbyl group” refers to a hydrocarbon molecule or a hydrocarbyl molecular fragment in which one or more carbon atoms is replaced with an atom other than carbon, e.g., nitrogen, oxygen, sulfur, phosphorus or silicon, typically nitrogen, oxygen or sulfur. Similarly, the term “heteroalkyl” refers to an alkyl substituent that is heteroatom-containing, the term “heterocyclic” refers to a cyclic substituent that is heteroatom-containing, the terms “heteroaryl” and “heteroaromatic” respectively refer to “aryl” and “aromatic” substituents that are heteroatom-containing, and the like. It should be noted that a “heterocyclic” group or compound may or may not be aromatic, and further that “heterocycles” may be monocyclic, bicyclic, or polycyclic as described above with respect to the term “aryl.” Examples of heteroalkyl groups include alkoxyalkyl, alkylsulfanyl-substituted alkyl, N-alkylated amino alkyl, and the like. Examples of heteroaryl substituents include pyrrolyl, pyrrolidinyl, pyridinyl, quinolinyl, indolyl, pyrimidinyl, imidazolyl, 1,2,4-triazolyl, 1,2,3 triazolyl, tetrazolyl, etc., and examples of heteroatom containing alicyclic groups are pyrrolidino, morpholino, piperazino, piperidino, etc.

By “substituted” as in “substituted hydrocarbyl,” “substituted alkyl,” “substituted aryl,” and the like, as alluded to in some of the aforementioned definitions, is meant that in the hydrocarbyl, alkyl, aryl, or other moiety, at least one hydrogen atom bound to a carbon (or other) atom is replaced with one or more non-hydrogen substituents. Examples of such substituents include, without limitation: functional groups such as halo, hydroxyl, sulfhydryl, C₁-C₂₄alkoxy, C₂-C₂₄alkenyloxy, C₂-C₂₄alkynyloxy, C₅-C₂₄aryloxy, C₆-C₂₄aralkyloxy, C₆-C₂₄alkaryloxy, acyl (including C₂C₂₄alkylcarbonyl (—CO-alkyl) and C₆-C₂₄arylcarbonyl (—CO-aryl)), acyloxy (—O-acyl, including C₂C₂₄alkylcarbonyloxy (—O—CO-alkyl) and C₆-C₂₄arylcarbonyloxy (—O—CO-aryl)), C₂C₂₄alkoxycarbonyl (—(CO)—O— alkyl), C₆-C₂₄aryloxycarbonyl (—(CO)—O-aryl), halocarbonyl (—CO)X where X is halo), C₂-C₂₄alkylcarbonato (—O—(CO)—O-alkyl), C₆-C₂₄arylcarbonato (—O—(CO)—O-aryl), carboxy (—COOH), carboxylato (—COO⁻), carbamoyl (—(CO)—NH₂), mono-(C₁-C₂₄alkyl) substituted carbamoyl (—(CO)—NH(C₁-C₂₄alkyl)), di-(C₁-C₂₄alkyl)-substituted carbamoyl (—(CO)N(C₁-C₂₄alkyl)₂), mono-(C₅-C₂₄aryl)-substituted carbamoyl (—(CO)—NH-aryl), di-(C₅-C₂₄aryl) substituted carbamoyl (—(CO)—N(C₅-C₂₄aryl)₂), M(C₁-C₂₄alkyl) (C₅-C₂₄aryl))-substituted carbamoyl, thiocarbamoyl (—(CS)—NH₂), mono-(C₁-C₂₄alkyl)-substituted thiocarbamoyl (—(CS)NH(C₁-C₂₄alkyl)), di-(C₁-C₂₄alkyl)-substituted thiocarbamoyl (—(CS)—N(C₁-C₂₄alkyl)₂), mono-(C₅-C₂₄aryl)-substituted thiocarbamoyl (—(CS)—NH-aryl), di-(C₅-C₂₄aryl)-substituted thiocarbamoyl ((CS)—N(C₅-C₂₄aryl)₂), N—(C₁-C₂₄alkyl)N—(C₅-C₂₄aryl)-substituted thiocarbamoyl, carbamido (NH—(CO)—NH₂), cyano (—C═N), cyanato (—O—C═N), thiocyanato (—S—C═N), formyl (—(CO)—H), thioformyl (—(CS)—H), amino (—NH₂), mono-(C₁-C₂₄alkyl)-substituted amino, di-(C₁-C₂₄alkyl) substituted amino, mono-(C₅-C₂₄aryl)-substituted amino, di-(C₅-C₂₄aryl)-substituted amino, C₂-C₂₄alkylamido (—NH—(CO)-alkyl), C₆-C₂₄arylamido (—NH—(CO)-aryl), imino (—CR═NH where R=hydrogen, C₁-C₂₄alkyl, C₅-C₂₄aryl, C₆-C₂₄alkaryl, C₆-C₂₄aralkyl, etc.), C₂-C₂₀alkylimino (—CR═N(alkyl), where R=hydrogen, C₁-C₂₄alkyl, C₅-C₂₄aryl, C₆-C₂₄alkaryl, C₆-C₂₄aralkyl, etc.), arylimino (—CR═N(aryl), where R=hydrogen, C₁-C₂₀alkyl, C₅-C₂₄aryl, C₆-C₂₄alkaryl, C₆-C₂₄aralkyl, etc.), nitro (—NO₂), nitroso (—NO), sulfo (—SO₂—OH), sulfonato (—SO₂—O⁻), C₁-C₂₄alkylsulfanyl (—S-alkyl; also termed “alkylthio”), C₅-C₂₄arylsulfanyl (—S-aryl; also termed “arylthio”), C₁-C₂₄alkylsulfinyl (—(SO)-alkyl), C₅-C₂₄arylsulfinyl (—(SO)-aryl), C₁-C₂₄alkylsulfonyl (—SO₂-alkyl), C₅-C₂₄arylsulfonyl (—SO₂-aryl), boryl (—BH₂), borono (—B(OH)₂), boronato (—B(OR)₂where R is alkyl or other hydrocarbyl), phosphono (—P(O)(OH)₂), phosphonato (—P(O)(O)₂), phosphinato (—P(O)(O⁻)), phosphor (—PO₂), and phosphino (—PH₂); and the hydrocarbyl moieties C₁-C₂₄alkyl (preferably C₁-C₁₂alkyl, more preferably C₁-C₆alkyl), C₂-C₂₄alkenyl (preferably C₂-C₁₂alkenyl, more preferably C₂-C₆alkenyl), C₂-C₂₄alkynyl (preferably C₂-C₁₂alkynyl, more preferably C₂-C₆alkynyl), C₅-C₂₄aryl (preferably C₅-C₂₄aryl), C₆-C₂₄alkaryl (preferably C₆-C₁₆alkaryl), and C₆-C₂₄aralkyl (preferably C₆-C₁₆aralkyl).

By “functionalized” as in “functionalized hydrocarbyl”, “functionalized alkyl”, “functionalized olefin”, “functionalized cyclic olefin”, and the like, is meant that in the hydrocarbyl, alkyl, olefin, cyclic olefin, or other moiety, at least one hydrogen atom bound to a carbon (or other) atom is replaced with one or more functional groups such as those described hereinabove.

In addition, the aforementioned functional groups may, if a particular group permits, be further substituted with one or more additional functional groups or with one or more hydrocarbyl moieties such as those specifically enumerated above. Analogously, the above-mentioned hydrocarbyl moieties may be further substituted with one or more functional groups or additional hydrocarbyl moieties such as those specifically enumerated.

The present invention comprises a novel family of metathesis catalyst compounds useful for the different types of olefin and alkyne metathesis reactions, including but not limited to Ring closing metathesis (RCM), Cross metathesis (CM), Ring opening metathesis (ROM), Ring opening metathesis polymerization (ROMP), acyclic diene metathesis (ADMET), self-metathesis, conversion of olefins with alkynes (enyne metathesis), polymerization of alkynes, ethylene cross-metathesis and so on.

M is a Group 8 metal, preferably ruthenium or osmium,

R¹-R⁶are identical or different and represents hydrogen, halogen, hydroxyl, aldehyde, keto, thiol, CF₃, nitro, nitroso, cyano, thiocyano, isocyanates, carbodiimide, carbamate, thiocarbamate, dithiocarbamate, amino, amido, imino, ammonium, silyl, sulphonate (—SO₃⁻), —OSO₃⁻, —PO₃⁻or —OPO₃⁻, acyl, acyloxy or represents alkyl, cycloalkyl, alkenyl, cycloalkenyl, substituted alkenyl, heteroalkenyl, heteroatom-containing alkynyl, alkenylene, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, carboxylate, alkoxy, alkenyloxy, alkynyloxy, aryloxy, alkaryl, aralkyl, alkaryloxy, aralkyloxy, alkoxycarbonyl, alkylamino-, alkylthio-, arylthio, alkyl sulfonyl, alkylsulfinyl, dialkylamino, alkylammonium, alkyl silyl or alkoxysilyl, where these radicals may each optionally all be substituted by one or more aforementioned groups defined for R¹-R⁶, and except that R²does not represent phenyl when R¹═R³═R⁴═R⁵=R⁶═H;

or alternatively in each case two directly adjacent radicals from the group of R¹-R⁶, including the ring carbon atoms to which they are attached by a cyclic bridging group, generating one or more cyclic structures, including aromatic structures.

C₁-C₆alkyl is, but not limited to, for example methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, neo-pentyl, 1-ethyl-propyl and n-hexyl.

C₃-C₈cycloalkyl includes, but not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.

C₆-C₂₄aryl includes an aromatic radical having 6 to 24 skeletal carbon atoms. Preferred mono-, bi- or tricyclic carbocyclic aromatic radicals have 6 to 10 skeletal carbon atoms, for example but not limited to, phenyl, biphenyl, naphthyl, phenanthrenyl or anthracenyl.

X¹preferably represents an anionic ligand.

In the general formulas X¹can be for example, hydrogen, halogen, pseudohalogen, straight-chain or branched C₁-C₃₀alkyl, C₆-C₂₄aryl, C₁-C₂₀alkoxy, C₆-C₂₄aryloxy, C₃-C₂₀alkyl diketonate, C₆-C₂₄aryl diketonate, C₁-C₂₀carboxylate, C₁-C₂₀alkylsulfonate, C₆-C₂₄aryl sulfonate, C₁-C₂₀alkyl thiol, C₆-C₂₄aryl thiol, C₁-C₂₀alkyl sulfonyl or C₁-C₂₀alkylsulfinyl-radicals.

The abovementioned radical X¹may further be substituted by one or more additional residues, for example by halogen, preferably fluorine, C₁-C₂₀alkyl, C₁-C₂₀-alkoxy or C₆-C₂₄aryl, where these groups may optionally be in turn be substituted by one or more substituents from the group comprising halogen, preferable fluorine, C₁-C₅alkyl, C₁-C₅alkoxy, and phenyl.

L¹and X¹may be joined to form a multidentate monoanionic group and may form a single ring of up to 30 non-hydrogen atoms or a multinuclear ring system of up to 30 non-hydrogen atoms;

In a preferred embodiment, X¹denote halogen, in particular, fluorine, chlorine, bromine or iodine, benzoate, nitrate, C₁-C₅carboxylate, C₁-C₅alkyl, phenoxy, C₁-C₅alkoxy, C₁-C₅alkyl thiol, C₆-C₂₄arylthiol, C₆-C₂₄aryl or C₁-C₅alkyl sulfonate.

In a particularly preferred embodiment, X¹is chlorine, CF₃COO, CH₃COO, CFH₂COO, (CH₃)₃CO, nitrate, (CF₃)₂(CH₃)CO, (CF₃)(CH₃)₂CO, PhO (phenoxy), C₆F₅O (pentafluorophenoxy), MeO (methoxy), EtO (ethoxy), tosylate (p-CH₃—C₆H₄—SO₃), mesylate (2,4,6-trimethylphenyl) or CF₃SO₃(trifluoromethanesulfonate).

A¹-A²are identical or different and are selected from the group consisting of oxygen, sulphur, selenium, NR″″, PR″″, POR″″, AsR″″, AsOR″″, SbOR″″ and SbR″″.

T¹-T²are identical or different and selected from the group consisting of

Wherein E preferably represents a donor atom selected from the group consisting of nitrogen, phosphor, oxygen, sulphur, and selenium; wherein for the group

in case of oxygen, sulphur and selenium, R is omitted for double bonded E or R remains for a single bonded E; wherein for the group

in case of oxygen, sulphur and selenium, the E-C bound is a single bond and the C atom contains an extra R group or the C—R′ is a double bond or the C—R is a double bond.

R, R′, R″, R′″ and R″″ are identical or different and represents hydrogen, halogen, hydroxyl, aldehyde, keto, thiol, CF₃, nitro, nitroso, cyano, thiocyano, isocyanates, carbodiimide, carbamate, thiocarbamate, dithiocarbamate, amino, amido, imino, ammonium, silyl, sulphonate (—SO₃⁻), —OSO₃⁻, —PO₃⁻or —OPO₃⁻, acyl, acyloxy or represents alkyl, cycloalkyl, alkenyl, cycloalkenyl, substituted alkenyl, heteroalkenyl, heteroatom-containing alkynyl, alkenylene, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, carboxylate, alkoxy, alkenyloxy, alkynyloxy, aryloxy, alkaryl, aralkyl, alkaryloxy, aralkyloxy, alkoxycarbonyl, alkylamino-, alkylthio-, arylthio, alkyl sulfonyl, alkylsulfinyl, dialkylamino, alkylammonium, alkyl silyl or alkoxysilyl, where these radicals may each optionally all be substituted by one or more aforementioned groups defined for R, R′, R″, R′″ and R″″, wherein alternatively in each case two directly adjacent radicals from the group of R, R′, R″, R′″ and R″″, including the atoms to which they are attached, generating one or more cyclic structures, including aromatic structures.

C₁-C₆alkyl is, but not limited to, for example methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, neopentyl, 1-ethyl-propyl and n-hexyl.

C₃-C₈cycloalkyl includes, but not limited to, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl.

C₆-C₂₄aryl includes an aromatic radical having 6 to 24 skeletal carbon atoms. Preferred mono-, bi- or tricyclic carbocyclic aromatic radicals have 6 to 10 skeletal carbon atoms, for example but not limited to, phenyl, biphenyl, naphthyl, phenanthrenyl or anthracenyl.

Alternatively R is optionally substituted with a neutral donor ligand (L²) as defined by L¹.

C¹-C²are carbon atoms linked to each other via a single or double bond wherein in case of a single bond each carbon atom bears an extra substituent R^C1and R^C2.

R^C1and R^C2are identical or different and are as defined for R′, R″, R′″ and R″″.

L¹preferably represent neutral electron donor.

The ligand L¹may, for example, represent a phosphine, sulphonated phosphine, phosphate, phosphinite, phosphonite, phosphite, arsine, stibine, ether, amine, amide, sulfoxide, carboxyl, nitrosyl, pyridine, substituted pyridine, pyrazine, thiocarbonyl, thioether, triazole carbene, mesionic carbene (MIC), N-Heterocyclic carbene (“NHC”), substituted NHC, or cyclic alkyl amino carbene (CAAC) or substituted CAAC.

Preferably, ligand L¹represents a phosphine ligand having the formula P(Q¹)₃with Q¹are identical or different and are alkyl, preferably C₁-C₁₀alkyl, more preferably C₁-C₅-alkyl, cycloalkyl-, preferably C₃-C₂₀cycloalkyl, more preferably C₃-C₈cycloalkyl, preferably cyclopentyl, cyclohexyl, and neopentyl, aryl, preferably C₆-C₂₄aryl, more preferably phenyl or toluyl, C₁-C₁₀alkyl-phosphabicyclononane, C₃-C₂₀cycloalkyl phospha-bicyclononane, a sulfonated phosphine ligand of formula P(Q²)₃wherein Q²represents a mono- or poly-sulfonated Q¹-ligand; C₆-C₂₄aryl or C₁-C₁₀alkyl-phosphinite ligand, a C₆-C₂₄aryl or C₁-C₁₀alkyl phosphonite ligand, a C₆-C₂₄aryl or C₁-C₁₀alkyl phosphite-ligand, a C₆-C₂₄aryl C₁-C₁₀alkyl arsine ligand, a C₆-C₂₄aryl or C₁-C₁₀alkyl amine ligands, a pyridine ligand, a C₆-C₂₄aryl or C₁-C₁₀alkyl-sulfoxide ligand, a C₆-C₂₄aryl or C₁-C₁₀alkyl ether ligand or a C₆-C₂₄aryl or C₁-C₁₀alkyl amide ligands which all can be multiply substituted, for example by a phenyl group, wherein these substituents are in turn optionally substituted by one or more halogen, C₁-C₅alkyl or C₁-C₅alkoxy radicals.

The term “phosphine” includes, for example, PPh₃, P(p-Tol)₃, P(o-Tol), PPh(CH₃)₂, P(CF₃)₃, P(p-FC₆H₄)₃, P(p-CF₃C₆H₄)₃, P(C₆H₄—SO₃Na)₃, P(CH₂C₆H₄—SO₃Na)₃, P(iso-Propyl)₃, P(CHCH₃(CH₂CH₃))₃, P(cyclopentyl)₃, P(cyclohexyl)₃, P(Neopentyl)₃and cyclohexyl-phosphabicyclononane.

The term “phosphinite” includes for example triphenylphosphinite, tricyclohexylphosphinite, triisopropylphosphinite and methyldiphenylphosphinite.

The term “phosphite” includes, for example, triphenyl phosphite, tricyclohexyl phosphite, tri-tert-butyl phosphite, triisopropyl phosphite and methyldiphenylphosphite.

The term “stibine” includes, for example triphenylstibine, tricyclohexylstibine and Trimethylstibene.

The term “sulfonate” includes, for example, trifluoromethanesulfonate, tosylate and mesylate.

The term “sulfoxide” includes, for example, CH₃S(═O)CH₃and (C₆H₅)₂SO.

The term “thioether” includes, for example CH₃SCH₃, C₆H₅SCH₃, CH₃OCH₂CH₂SCH₃and tetra-hydrothiophene.

The term “pyridine” in this application is a generic term and includes all the unsubstituted and substituted nitrogen-containing ligands described in WO-A-03/011455 and U.S. Pat. No. 6,759,537 B2. Examples are: pyridine, picolines (α-, β-, and γ-picoline), lutidines (2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5-lutidine), collidine (2,4,6-trimethylpyridine), trifluoromethylpyridine, phenylpyridine, 4-(dimethylamino) pyridine, chloropyridines (2-, 3- and 4-chloropyridine), bromopyridines (2-, 3- and 4-bromopyridine), nitropyridines (2-, 3- and 4-nitropyridine), bipyridine, picolylimine, gamma-pyran, phenanthroline, pyrimidine, bipyrimide, pyrazine, indole, coumarine, carbazole, pyrazole, pyrrole, imidazole, oxazole, thiazole, dithiazole, isoxazole, isothiazole, quinoline, bisquinoline, isoquinoline, bisisoquinoline, acridine, chromene, phenazine, phenoxazine, phenothiazine, triazine, thianthrene, purine benzimidazole, bisimidazole, bisoxazole, pyrrole, imidazole and phenylimidazole.

In other useful embodiment ligand L¹represents a N-Heterocyclic carbene (NHC) usually having a structure of the formulas (IIIa) or (IIIb):

by which

R⁷-R¹⁴, R^11′, R^12′are identical or different and are hydrogen, halogen, hydroxyl, aldehyde, keto, thiol, CF₃, nitro, nitroso, cyano, thiocyano, isocyanates, carbodiimide, carbamate, thiocarbamate, dithiocarbamate, amino, amido, imino, ammonium, silyl, sulphonate (—SO₃⁻), —OSO₃⁻, —PO₃⁻or —OPO₃⁻, acyl, acyloxy or represents alkyl, cycloalkyl, alkenyl, cycloalkenyl, substituted alkenyl, heteroalkenyl, heteroatom-containing alkynyl, alkenylene, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, carboxylate, alkoxy, alkenyloxy, alkynyloxy, aryloxy, alkaryl, aralkyl, alkaryloxy, aralkyloxy, alkoxycarbonyl, alkylammonium, alkylamino-, alkylthio-, arylthio, alkylsulfonyl, alkylsulfinyl, dialkylamino, alkylsilyl or alkoxysilyl, where these radicals may each optionally all be substituted by one or more aforementioned groups defined for R¹-R⁶.

Optionally, one or more of the radicals R⁷-R¹⁴, R^11′, R^12′ independently of one another can be substituted by one or more substituents, preferably straight or branched C₁-C₁₀alkyl, C₃-C₈cycloalkyl, C₁-C₁₀alkoxy or C₆-C₂₄aryl, where these aforementioned substituents may in turn be substituted by one or more radicals, preferably selected from the group comprising halogen, especially chlorine or bromine, C₁-C₅alkyl, C₁-C₅alkoxy and phenyl.

Just for clarification, the depicted structures of the N-Heterocyclic carbene in the general formulas (IIIa) and (IIIb) are equal with the N-Heterocyclic carbenes described in the literature, where frequently the structures (IIIa′) and (IIIb′) are used, which highlighting the carbene character of N-Heterocyclic carbene. This also applies to the corresponding preferred, structures shown below (IVa)-(IVf)

In a preferred embodiment of the catalysts the general formulas (IIIa) and (IIIb) R⁷, R⁸, R¹¹, R^11′ R¹²and R^12′ are independently of one another denote hydrogen, C₆-C₂₄-aryl, particularly preferably phenyl, straight or branched C₁-C₁₀alkyl, particularly preferably propyl or butyl, or together with the inclusion of the carbon atoms to which they are attached form a cycloalkyl or aryl radical, where all the abovementioned radicals are optionally substituted may be substituted by one or more further radicals selected from the group comprising straight or branched C₁-C₁₀alkyl, C₁-C₁₀alkoxy, C₆-C₂₄aryl, and a functional group selected from the group consisting of hydroxy, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, and halogen.

In a particularly preferred embodiment, the catalysts of the general formulas (I-II) have one N-Heterocyclic carbene (NHC) as ligand L¹, where the radicals R⁹, R¹⁰, R¹³and R¹⁴are identical or different and are straight or branched C₁-C₁₀alkyl, particularly preferably i-propyl or neopentyl, C₃-C₁₀cycloalkyl, preferably adamantyl, C₆-C₂₄aryl, particularly preferably phenyl, C₁-C₁₀alkylsulfonate, particularly preferably methanesulphonate, C₁-C₁₀aryl sulphonate, particularly preferably p-toluenesulfonate.

If necessary, the above-mentioned residues are substituted as the meanings of R⁹, R¹⁰, R¹³and R¹⁴by one or more further radicals selected from the group comprising straight or branched C₁-C₅alkyl, especially methyl, C₁-C₅alkoxy, aryl and a functional group selected from the group consisting of hydroxy, thiol, thioether, ketone, aldehyde, ester, ether, amine imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, and halogen.

In particular, the radicals R⁹, R¹⁰, R¹³and R¹⁴can be identical or different and denote i-propyl, neopentyl, adamantyl, mesityl or 2,6-diisopropylphenyl.

Particularly preferred N-Heterocyclic carbenes (NHC) have the following structure (IVa)-(IVf), in which Mes stands for a 2,4,6-trimethylphenyl radical or alternatively, in all cases, for a 2,6-diisopropylphenyl radical.

In alternative embodiment, the neutral ligand L may be selected from a ligand of any of the formulas (Va-Vc):

R⁸, R⁹, R¹⁰, R¹¹, R^11′, R¹², R¹³, R¹⁴are identical or different and are equal to R³-R⁶defined as herein-above. Any adjacent group of R¹¹, R^11′and R¹²in structure (Vb) and (Vc) may form a 3, 4, 5, 6, or 7 membered cycloalkyl, alkylene bridge, or aryl.

In other useful embodiments, one of the N groups bound to the carbene in Formula (IIIa) or (IIIb) is replaced with another heteroatom, preferably S, O or P, preferably an S heteroatom. Other useful N-heterocyclic carbenes include the compounds described in Chem. Eur. J 1996, 2, 772 and 1627; Angew. Chem. Int. Ed. 1995, 34, 1021; Angew. Chem. Int. Ed. 1996, 35, 1121; and Chem. Rev. 2000, 100, 39.

For purposes of this invention and claims thereto, “cyclic alkyl amino carbenes” (CAACs) are represented by the Formula (VI):

Wherein the ring A is a 4-, 5-, 6-, or 7-membered ring, and Z is a linking group comprising from one to four linked vertex atoms selected from the group comprising C, O, N, B, Al, P, S and Si with available valences optionally occupied by hydrogen, oxo or R-substituents, wherein R is independently selected from the group comprising C₁to C₁₂hydrocarbyl groups, substituted C₁to C₁₂hydrocarbyl groups, and halides, and each R¹⁵is independently a hydrocarbyl group or substituted hydrocarbyl group having 1 to 40 carbon atoms, preferably methyl, ethyl, propyl, butyl (including isobutyl and n-butyl), pentyl, cyclopentyl, hexyl, cyclohexyl, octyl, cyclooctyl, nonyl, decyl, cyclodecyl, dodecyl, cyclododecyl, mesityl, adamantyl, phenyl, benzyl, toluyl, chlorophenyl, phenol, or substituted phenol.

Some particularly useful CAACs include:

Other useful CAACs include the compounds described in U.S. Pat. No. 7,312,331 and in Angew. Chem. Int. Ed. 2005, 44, 7236-7239.

For the case that the R group present in T¹or T²of the inventive catalysts with the general formula (I) is further substituted with a neutral donor ligand, the following examples can be generated with the structures of the general formula (VII).

Wherein the ring G is a 4-, 5-, 6-, 7-, 8-, 9- or 10-membered ring, and Z is a linking group comprising from one to seven linked vertex atoms selected from the group comprising C, O, N, P, S and Si with available valences optionally occupied by hydrogen, halogen, hydroxyl, aldehyde, keto, thiol, CF₃, nitro, nitroso, cyano, thiocyano, isocyanates, carbodiimide, carbamate, thiocarbamate, dithiocarbamate, amino, amido, imino, ammonium, silyl, sulphonate (—SO₃⁻), —OSO₃⁻, —PO₃⁻or —OPO₃⁻, acyl, acyloxy or represents alkyl, cycloalkyl, alkenyl, cycloalkenyl, substituted alkenyl, heteroalkenyl, heteroatom-containing alkynyl, alkenylene, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, carboxylate, alkoxy, alkenyloxy, alkynyloxy, aryloxy, alkaryl, aralkyl, alkaryloxy, aralkyloxy, alkoxycarbonyl, alkylamino-, alkylthio-, arylthio, alkyl sulfonyl, alkylsulfinyl, dialkylamino, alkylammonium, alkylsilyl or alkoxysilyl, where these vertex atoms may each optionally all be substituted by one or more aforementioned groups defined for R, R″, R′″ and R″″,

or alternatively in each case two directly adjacent vertex atoms from Z generate one or more cyclic structures, including aromatic structures.

L¹and L²are identical or different ligands, preferably represent neutral electron donors, and L²has the same meaning as L¹as defined in structures (I-II)

wherein M, X¹, A¹, T¹, L¹, R¹-R⁶and R′, R″, R′″ and R″″ have the same meanings as defined in the general structures (I-II).

As examples of the catalysts of the invention, the following structures may be mentioned:

In certain embodiments, the catalyst compound employed in the olefin metathesis processes may be bound to or deposited on a solid catalyst support. The solid catalyst support will make the catalyst compound heterogeneous, which will simplify catalyst recovery. In addition, the catalyst support may increase catalyst strength and attrition resistance. Suitable catalyst supports include, without limitation, silica's, alumina's, silica-alumina's, aluminosilicates, including zeolites and other crystalline porous aluminosilicates; as well as titania's, zirconia, magnesium oxide, carbon, carbon nanotubes, graphene, Metal organic frameworks and cross-linked, reticular polymeric resins, such as functionalized cross-linked polystyrenes, e.g., chloromethyl-functionalized cross-linked polystyrenes.

The catalyst compound may be deposited onto the support by any method known to those skilled in the art, including, for example, impregnation, ion-exchange, deposition-precipitation, II-II interactions and vapor deposition. Alternatively, the catalyst compound may be chemically bound to the support via one or more covalent chemical bonds, for example, the catalyst compound may be immobilized by one or more covalent bonds with one or more of substituents of the indenylidene ligand or directly immobilized via one or more chemical bounds on the Group 8 metal by substituting one or more anionic ligands or immobilized via one or more chemical bounds between the ligand and the support.

If a catalyst support is used, the catalyst compound may be loaded onto the catalyst support in any amount, provided that the metathesis process proceeds to the desired metathesis products. Generally, the catalyst compound is loaded onto the support in an amount that is greater than about 0.01 wt % of the Group 8 metal, based on the total weight of the catalyst compound plus support. Generally, the catalyst compound is loaded onto the support in an amount that is less than about 20 wt % of the Group 8 metal, based on the total weight of the catalyst compound and support.

In general, acetylenic compounds useful in this invention may contain a chelating moiety of the formula (VIII)

wherein,

D is a leaving group;

R¹⁶to R¹⁷are as defined below;

R¹⁶is selected from hydrogen, halogen, alkyl, alkenyl, alkynyl, aryl, heteroalkyl, heteroatom containing alkenyl, heteroalkenyl, heteroaryl, alkoxy, alkenyloxy, aryloxy, alkoxycarbonyl, carbonyl, alkylamino, alkylthio, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkyl sulfonyl, nitrile, nitro, alkylsulfinyl, trihaloalkyl, perfluoroalkyl, carboxylic acid, ketone, aldehyde, nitrate, cyano, isocyanate, hydroxyl, ester, ether, amine, imine, amide, halogen-substituted amide, trifluoroamide, sulfide, disulfide, sulfonate, carbamate, silane, siloxane, phosphine, phosphate, or borate, and wherein when R¹⁶is aryl, polyaryl, or heteroaryl, R¹⁶may be substituted with any combination of R¹, R², R³, R⁴, R⁵, and R⁶and can be linked with any of R¹, R², R³, R⁴, R⁵, and R⁶to form one or more cyclic aromatic or non-aromatic groups.

R¹⁷is selected from annulenes, having the general formula C_nH_n(when n is an even number) or C_nH_n+1(when n is an odd number). Well-know representative compounds of annulenes, but not limited, are cyclobutadiene, benzene, and cyclooctatetraene. Annulenes can be aromatic or anti-aromatic. Every H-atom from the annulene fragment can be substituted by halogen, alkyl, alkenyl, alkynyl, aryl, heteroalkyl, heteroatom containing alkenyl, heteroalkenyl, heteroaryl, alkoxy, alkenyloxy, aryloxy, alkoxycarbonyl, carbonyl, alkylamino, alkylthio, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkyl sulfonyl, nitrile, nitro, alkylsulfinyl, trihaloalkyl, perfluoroalkyl, carboxylic acid, ketone, aldehyde, nitrate, cyano, isocyanate, hydroxyl, ester, ether, amine, imine, amide, halogen-substituted amide, trifluoroamide, sulfide, disulfide, sulfonate, carbamate, silane, siloxane, phosphine, phosphate, or borate, and wherein when R¹⁷is aryl, polyaryl, or heteroaryl, R¹⁷may be substituted with any combination of R¹, R², R³, R⁴, R⁵, and can be linked with any of R¹, R², R³, R⁴, R⁵and R⁶to form one or more cyclic aromatic or non-aromatic groups.

Examples of suitable leaving groups include, but are not limited to, hydroxyl, halide, ester, perhalogenated phenyl, acetate, benzoate, C₂-C₆acyl, C₂-C₆alkoxycarbonyl, C₁-C₆alkyl, phenoxy, C₁-C₆alkoxy, C₁-C₆alkylsulfanyl, aryl, or C₁-C₆alkylsulfonyl. In even more preferred embodiments, D is selected from hydroxyl, halide, CF₃CO₂, CH₃CO₂, CFH₂CO₂, (CH₃)₃CO₃(CF₃)₂(CH₃)CO, (CF₃)(CH₃)₂CO, PhO, MeO, EtO, tosylate, mesylate, or trifluoromethane-sulfonate. In particular embodiments, D is advantageously hydroxyl (OH).

Preferred organic acetylenic compounds are of the formula (IX),

Wherein

m* is an integer from 1 to 5;

R* is selected from R¹, R², R³, R⁴, R⁵and R⁶, or combinations thereof, as defined above.

D and R¹⁶are as defined above.

Preferred organic acetylenic compounds include:

Synthesis of Metathesis Catalyst Compounds

The catalyst compounds described in this invention may be synthesized by any methods known to those skilled in the art.

Representative methods of synthesizing the Group 8 catalyst compound of the type described herein include, for example, treating a solution of the acetylenic compound in a suitable solvent, such as dioxane, with a reactant complex of a Group 8 metal, such as dichlorobis-(triphenylphosphine)ruthenium(II) and hydrogen chloride (in dioxane). The reaction mixture may be heated, for a time period appropriate to yield the desired modified indenylidene catalyst compound. Typically, removal of the volatiles and washed with hexane affords the Group 8 modified indenylidene 1^stgeneration compound (Scheme 4) in high yields (>80%).

A phosphine ligand, such as tricyclohexylphosphine, cyclohexyl-phosphabicyclononane, a phosphinite or a phosphinite may be added thereafter, if desired. The reaction conditions typically include mixing the Group 8 reactant compound and the preferred phosphine ligand in a suitable solvent, e.g. dichloromethane, for a time sufficient to effectuate the phosphine ligand exchange, at a suitable temperature typically ambient, yield (>90%).

A N-Heterocyclic carbenes (NHC), such as 1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene, 1,3-bis(2,6-diisopropylphenyl)-2-imidazolidinylidene or a CAAC may be added 1^stgeneration compound (Scheme 4), if desired. The reaction conditions typically include mixing the Group 8 reactant 1^stgeneration compound (Scheme 4) and the preferred NHC, CAAC ligand in a suitable solvent, e.g. toluene, for a time sufficient to effectuate the phosphine ligand exchange, at a suitable temperature typically between ambient and 80° C. Addition of isopropanol followed by filtration and washing, the desired 2^ndgeneration compound (Scheme 4) is obtained in high yield (>85%).

A pyridine ligand, such as pyridine, 3-Br pyridine may be added 2^ndgeneration compound (Scheme 4), if desired. The reaction conditions typically include mixing the Group 8 reactant 2^ndgeneration compound (Scheme 4) and the preferred pyridine ligand in as solvent, for a time sufficient to effectuate the phosphine ligand exchange, at a suitable temperature typically between ambient and 80° C. Filtration and washing gives the desired 3^rdgeneration compound (Scheme 4) in high yield (>85%).

Scheme 4: different generations of non-chelating modified indenylidene catalysts.

Treating a solution of the ditopic (or multitopic) ligand, e.g. O,N-bidentate ligands, in a suitable solvent, such as THF, with a 1^stor 2^ndor 3^rdgeneration non-chelating modified indenylidene complex (see scheme 4), e.g. (Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methylphenyl-inden-1-ylidene in a 1:1 ratio and adding a required amount of silver (e.g. AgO₂) for a time sufficient to effectuate the ligand exchange, at a suitable temperature typically between ambient and 80° C. to yield the desired modified indenylidene catalyst compound. The reaction temperature was then lowered to room temperature, the white precipitate of PCy₃AgCl (byproduct) and excess of Ag₂O was removed by filtration and the filtrate was concentrated under reduced pressure. The isolated solid residue provides the desired product (type I) in high yield (>85%).

Treating a solution of the ditopic (or multitopic) ligand, e.g. O,N-bidentate ligands, in a suitable solvent, such as THF, with a 1^stor 2^ndor 3^rdgeneration non-chelating modified indenylidene complex (see scheme 4), e.g. (Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methylphenyl-inden-1-ylidene in a 2:1 ratio and adding an equivalent amount of silver (e.g. AgO₂) for a time sufficient to effectuate the ligand exchange, at a suitable temperature typically between ambient and 80° C. to yield the desired modified indenylidene catalyst compound. The reaction temperature was then lowered to room temperature, the white precipitate of PCy₃AgCl (byproduct) and excess of Ag₂O was removed by filtration and the filtrate was concentrated under reduced pressure. The isolated solid residue provides the desired product (type II) in high yield (>85%).

Treating a solution of the ditopic (or multitopic) ligand, e.g. O,N-bidentate ligands, in a suitable solvent, such as THF, with a catalyst of type I in a 1:1 ratio and adding a required amount of silver (e.g. AgO₂) for a time sufficient to effectuate the ligand exchange, at a suitable temperature typically between ambient and 80° C. to yield the desired modified indenylidene catalyst compound. The reaction temperature was then lowered to room temperature, the white precipitate of PCy₃AgCl (byproduct) and excess of Ag₂O was removed by filtration and the filtrate was concentrated under reduced pressure. The isolated solid residue provides the desired product (type II) in high yield.

The exchange of the ditopic (or multitopic) ligands can also be performed by generating first the salt of the ligand (Sodium, Potassium, Magnesium, Thallium salts, . . . ) as is well-know by persons skilled in the art.

Examples, but not limited, of ditopic or multitopic ligands are described in WO2005035121, European patent 1 468 004, EP 08 290 747.

While the present invention describes a variety of transition metal complexes useful in catalyzing metathesis reactions, it should be noted that such complexes may be formed in situ. Accordingly, additional ligands may be added to a reaction solution as separate compounds, or may be complexed to the metal center to form a metal-ligand complex prior to introduction to the reaction.

Synthetic protocols for representative 1,1-substituted prop-2-yn-1-ol ligands, ditopic, multitopic ligands and the corresponding ruthenium alkylidene complexes are as follows. Other substituted prop-2-yn-1-ol, ditopic, multitopic ligands and their respective metal complexes may be derived analogously.

To a solution of 2-bromotoluene (2 eq., 2.6 ml, 21.79 mmol,) in 26 ml diethyl ether at −90° C., t-BuLi (1.9 M in pentane) (3 eq., 32.7 mmol, 17.2 ml.) was added drop wise. The solution was stirred for 30 min. at room temperature, followed by drop wise addition of N,N-dimethylcarbamoyl chloride (1 eq., 1 ml, 10.9 mmol), the reaction mixture was stirred for another 3 hours. The crude reaction mixture was quenched using 35 ml 1N HCl and diluted with diethyl ether. The organic phase was washed with water and the aqueous phase was extracted twice with diethyl ether, thereafter the ether fractions were combined and dried with anhydrous MgSO₄. Removal of MgSO₄by filtration followed by purification using flash column chromatography (silica gel, hexane as solvent) and finally evaporation of the solvent and a white solid was obtained 0.93 g (40.6%).

¹H NMR (300 MHz, CDCl₃, TMS): δ 7.38 (td, 2H), 7.29 (td, 4H), 7.20 (td, 2H), 2.44 (s, 6H).

¹³C NMR (75 MHz, CDCl₃): δ 200.79, 139.01, 138.17, 131.43, 131.07, 130.31, 125.42, 20.67.

n-BuLi (2.5 M in hexanes) (1.5 eq., 5.7 ml, 14.28 mmol,) was added drop wise to stirred solution of trimethylsilylacetylene (1.5 eq., 2 ml, 14.28 mmol) in anhydrous THF (17 ml) at −90° C. under an argon atmosphere. After addition, the resulting solution was stirred for another 5 min in a cold bath followed by stirring for 30 minutes at room temperature. Thereafter, bis(2-methylphenyl)methanone (9.52 mmol, 2 g) in 17 ml dry THF was added slowly to the solution at −90° C. and the resulting mixture was allowed to heat up and refluxed for 30 min. The crude reaction mixture was quenched using 15 ml 1N HCl and diluted with diethyl ether. The organic phase was washed with water and the aqueous phase were combined and extracted twice with ether, thereafter the ether fractions were combined and dried with anhydrous MgSO₄. After removal of MgSO₄by filtration, and evaporation of the solvent a yellow liquid was obtained in quantitative yield. The obtained product was used without further purification.

¹H NMR (300 MHz, CDCl₃, TMS): δ 7.95 (dd, 2H), 7.27 (dd, 4H), 7.15 (dd, 2H) 2.75 (s, 1H) 2.14 (s, 6H), 0.27 (d, 9H).

¹³C NMR (75 MHz, CDCl₃): δ 141.01, 136.76, 132.37, 128.13, 127.45, 125.58, 107.10, 92.44, 75.01, 21.40, 0.00.

A solution of 1,1-bis-methylphenyl-3-(trimethylsilyl)prop-2-yn-1-ol was obtained from previous step and K₂CO₃(1 eq, 1.3 g 9.52 mmol) in dry methanol (10 ml) was stirred at room temperature for 3 h. The crude reaction mixture was quenched using 20 ml 1N HCl and diluted with diethyl ether. The organic phase was washed with water and the aqueous phase was extracted twice with diethyl ether, thereafter the ether fractions were combined and dried on anhydrous MgSO₄. Removal of MgSO₄by filtration followed by purification using flash column chromatography (silica gel, Hexane/EtOAc=30/1) and finally evaporation of the solvent a yellowish solid (2.06 g, 92% yield for step 2+3) was obtained.

¹H NMR (300 MHz, CDCl₃, TMS): δ 7.95 (m, 2H), 7.23 (m, 4H), 7.09 (m, 2H) 2.89 (s, 1H) 2.67 (s, 1H), 2.02 (s, 6H).

¹³C NMR (75 MHz, CDCl₃): δ 140.60, 136.33, 132.30, 128.19, 127.24, 125.58, 85.52, 76.80, 74.75, 21.16.

ESI[M-OH]: 219.1, calculated: 219.1.

(PPh₃)₃RuCl₂(1 eq., 0.575 g, 0.6 mmol) and 1,1-bis-2-methylphenyl-prop-2-yn-1-ol (compound C, 1.5 eq., 0.213 g, 0.9 mmol) were added in 4 ml HCl/dioxane solution (0.15 mol/1). The solution was heated to 90° C. for 3 hour, after which the solvent was removed under vacuum. Hexane (20 ml) was added to the flask and the solid was ultrasonically removed from the wall. The resulting suspension was filtered and washed two times using hexane (5 ml). The remaining solvent was evaporated affording a red-brown powder; 0.52 g (Yield: 95%). The product was characterized by NMR spectra¹H and³¹P.

¹H NMR (300 MHz, CDCl₃, TMS): δ 7.56 (dd, 11H), 7.37 (t, 6H), 7.21-7.31 (m, 13H), 7.09 (tetra, 3H), 6.95 (t, 3H), 6.47 (t, 1H), 6.14 (s, 1H), 2.20 (s, 3H), 1.66 (s, 3H).

³¹P NMR (121.49 MHz, CDCl₃): δ 29.33.

A 25 ml vial was charged with (PPh₃)₂Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene) (1 eq., 0.4574 g, 0.5 mmol), tricyclohexylphosphine (3 eq., 0.42 g, 1.5 mmol) and dichloromethane (10 ml). After completion of the reaction (1 h) the resulting slurry was dried under vacuum and 20 ml isopropanol was added. Filtration afforded a red-brown powder, which after washing with 5 ml isopropanol (2×) and drying under vacuum afforded 0.44 g of catalyst (Yield: 93%). The product was characterized by NMR spectra¹H and³¹P.

¹H NMR (300 MHz, CDCl₃, TMS): δ 8.54 (d, 1H), 7.24-7.29 (m, 1H), 7.10-7.17 (m, 4H), 7.07 (s, 1H), 7.02 (d, 1H), 2.61 (d, 6H), 2.22 (s, 3H), 1.18-1.96 (m, 63H).

³¹P NMR (121.49 MHz, CDCl₃): δ 31.75, 31.56.

Characteristic values of¹H and³¹P: H—C8: 8.54 ppm (d, 1H) and P: 31.75 and 31.56 ppm.

(PCy₃)₂Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene (0.53 mmol) and 2-[(4-bromo-2,6-dimethylphenylimino)methyl]-4-nitrophenol (0.53 mmol) (synthesized according the literature), silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P NMR, which revealed quantitative transformation to complex 1F.

Characteristic values of¹H and³¹P: H—C8: 6.75 ppm (d, 1H) and P: 39.65 ppm.

The isolated solid residue was recrystallized from pentane to provide the catalyst. Yield after recrystallization: 75%.

A 10 mL vial was charged with (PCy₃)₂Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene) (1 eq., 0.3804 g, 0.4 mmol) and 5-IMes (1.1 eq., 0.134 g, 0.44 mmol). Dry toluene (3 ml) was added under inert atmosphere. The mixture was vigorously stirred at 50° C. for 30 minutes and dried under vacuum followed by addition of 10 ml isopropanol. After filtration and washing (two times 5 ml isopropanol), an orange powder was obtained; 0.33 g (Yield: 84%). The product was characterized by NMR spectra¹H,¹³C, and³¹P.

¹H NMR (300 MHz, CDCl₃, TMS): δ 8.47 (d, 1H), 7.44 (dd, 1H), 7.20-7.28 (m, 2H), 7.04-7.11 (m, 3H), 6.99 (d, 1H), 6.93 (s, 1H), 6.88 (d, 1H), 6.81 (s, 1H), 6.05 (s, 1H), 3.70-4.07 (m, 4H), 2.74 (s, 3H), 2.68 (s, 3H), 2.38 (s, 3H), 2.33 (s, 3H), 2.14 (s, 3H), 2.02 (s, 3H), 1.87 (s, 3H), 0.86-1.83 (m, 36H).

¹³C NMR (75 MHz, CDCl₃): δ 294.06, 293.96, 217.16, 216.19, 143.91, 140.11, 139.79, 139.52, 139.39, 138.77, 138.29, 136.94, 136.85, 136.27, 135.69, 134.04, 130.70, 130.01, 129.88, 129.57, 128.94, 128.58, 128.14, 127.25, 127.13, 126.27, 125.30, 125.05, 52.68, 52.64, 52.29, 52.26, 33.09, 32.87, 29.47, 29.24, 27.70, 27.57, 26.20, 21.18, 20.91, 20.32, 20.15, 19.36, 18.97, 18.92, 18.44.

³¹P NMR (121.49 MHz, CDCl₃): δ 26.75.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methylphenyl-inden-1-ylidene)(0.51 mmol) and 2-[(2-methylphenylimino)methyl]-4-nitrophenol (0.51 mmol) and silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P NMR, which revealed quantitative transformation to complex 2B.

Characteristic values of¹H: H—C8: 8.39 ppm (d, 1H). (no³¹P NMR peak present in the complex)

The isolated solid residue provided the catalyst in 85% yield.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methylphenyl-inden-1-ylidene) (0.51 mmol) and 2-[(2-chlorophenylimino)methyl]-4-nitrophenol (0.51 mmol) and silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P NMR, which revealed quantitative transformation to complex 3A.

Characteristic values of¹H: H—C8: 8.33 ppm (d, 1H). (no³¹P NMR peak present in the complex)

The isolated solid residue provided the catalyst in 87% yield.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene (0.51 mmol) and 2-[(4-bromo-2,6-dimethylphenylimino)methyl]-4-nitrophenol (0.53 mmol) and silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P NMR, which revealed quantitative transformation to complex 4A.

Characteristic values of¹H: H—C8: 8.45 ppm (d, 1H). (no³¹P-NMR peak present in the complex)

The isolated solid residue provided the catalyst in 89% yield.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene (0.51 mmol) and 2-[(2,6-dimethylphenylimino)methyl]-4-nitrophenol (0.53 mmol) and silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P-NMR, which revealed quantitative transformation to complex 5A.

Characteristic values of¹H: H—C8: 8.87 ppm (d, 1H). (no³¹P-NMR peak present in the complex)

The isolated solid residue provided the catalyst in 91% yield.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene (0.51 mmol) and 2-[(2,6-dimethylphenylimino)methyl]-phenol (0.53 mmol) and silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P-NMR, which revealed quantitative transformation to complex X6A.

Characteristic values of¹H: H—C8: 9.10 ppm (d, 1H). (no³¹P-NMR peak present in the complex)

The isolated solid residue provided the catalyst in 91% yield.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene (0.51 mmol) and 2-[(2,6-dimethylphenylimino)methyl]-4-methoxyphenol (0.53 mmol) and silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P-NMR, which revealed quantitative transformation to complex 7A.

Characteristic values of¹H: H—C8: 9.15 ppm (d, 1H). (no³¹P-NMR peak present in the complex)

The isolated solid residue provided the catalyst in 87% yield.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene (0.51 mmol) and 2-[pentafluorophenylimino)methyl]-4-nitrophenol (0.53 mmol) and silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P-NMR, which revealed quantitative transformation to complex 8A.

Characteristic values of¹H: H—C8: 8.25 ppm (d, 1H). (no³¹P-NMR peak present in the complex)

The isolated solid residue provided the catalyst in 82% yield.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene (0.51 mmol) and 2-[(3s,5s,7s)-adamantan-1-yliminomethyl]-4-nitrophenol (0.51 mmol) and silver(I) oxide (0.31 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P NMR, which revealed quantitative transformation to complex 9A.

Characteristic values of¹H: H—C8: 8.39 ppm (d, 1H). (no³¹P NMR peak present in the complex)

The isolated solid residue provided the catalyst in 84% yield.

Ethynylmagnesium bromide (1.2 eq, 12.7 mmol, 25.4 ml) (0.5M in THF) was added to (i-propyl)(phenyl)methanone (1 eq., 10.6 mmol, 1.57 g) in dry THF (7 ml). The resulting solution was allowed to heat up under reflux overnight. The crude mixture was quenched by addition of 1N HCl (15 ml) and diluted with diethyl ether. The organic layer was separated; the aqueous layer was extracted twice with diethyl ether. The organic layers were combined dried on anhydrous MgSO₄, filtered, and concentrated under vacuum. The product obtained after column chromatography (Hexane: EtOAc 20:1) is a yellow liquid 1.75 g yield 95%.

¹H NMR (300 MHz, CDCl₃): δ 7.61 (dt, 2H), 7.22-7.36 (m, 3H), 2.66 (s, 1H), 2.50 (s, 1H), 2.09 (sept, 1H), 1.06 (d, 3H), 0.81 (d, 3H).

¹³C NMR (75 MHz, CDCl₃): δ 143.42, 127.95, 127.74, 126.14, 85.03, 77.07, 74.99, 40.16, 17.90, 17.38.

(PPh₃)₃RuCl₂(1 eq., 0.575 g, 0.6 mmol) and 1-(i-propyl)-1-phenylprop-2-yn-1-ol (compound 18A, 1.5 eq., 0.144 g, 0.9 mmol) were added in 4 ml HCl/dioxane solution (0.15 mol/1). The solution was heated to 90° C. for 3 hour, after which the solvent was removed under vacuum. Hexane (20 ml) was added to the flask and the solid was ultrasonically removed from the wall. The resulting suspension was filtered and washed two times using hexane (5 ml). The remaining solvent was evaporated affording a red-brown powder; 0.48 g (Yield: 93%). The product was characterized by NMR spectra³¹P.

³¹P NMR (121.49 MHz, CDCl₃): δ 29.55.

A 25 ml vial was charged with (PPh₃)₂Cl₂Ru(3-i-propyl-inden-1-ylidene) (1 eq., 0.4260 g, 0.5 mmol), tricyclohexylphosphine (3 eq., 0.42 g, 1.5 mmol) and dichloromethane (10 ml). After completion of the reaction (1 h) the resulting slurry was dried under vacuum and 20 ml isopropanol was added. Filtration afforded a red brown powder, which after washing with 5 ml isopropanol (2×) and drying under vacuum afforded 0.40 g of catalyst (Yield: 90%). The product was characterized by NMR spectra¹H and³¹P.

Characteristic values of¹H and³¹P: H—C8: 8.57 ppm (d, 1H) and P: 31.44 ppm.

(Simes)(PCy₃)Cl₂Ru(3-isopropyl-inden-1-ylidene) (0.50 g, 0.55 mmol) and 2-[(2-methylphenylimino)methyl]-4-nitrophenol (0.14 g, 0.55 mmol), and silver(I) oxide (0.33 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P-NMR, which revealed quantitative transformation to complex 10D.

Characteristic values of¹H: H—C8: 8.29 ppm (d, 1H). (no³¹P-NMR peak present in the complex)

The isolated solid residue provided the catalyst in 84% yield.

Salicylaldehyde (37.54 mmol, 4.00 mL), 1-(3-aminopropyl)imidazole (37.54 mmol, 4.50 mL) and 15 ml ethyl alcohol were added to a 100 ml flask and refluxed for 4 hours. The resulting yellow solution was cooled overnight, filtered and washed with cold ethanol (3×1 mL). Bright yellow crystals were isolated in 90% yield.

¹H NMR (300 MHz, CDCl₃) δ 13.09 (s, 1H), 8.25 (s, 1H), 7.39 35 (s, 1H), 7.26 (t, J=7.8 Hz, 1H), 7.18 (d, J=8.2 Hz, 1H), 7.01 (s, 1H), 6.93-6.79 (m, 3H), 4.00 (t, J=6.9 Hz, 2H), 3.48 (t, J=6.5 Hz, 2H), 2.12 (p, J=6.7 Hz, 2H).¹³C NMR (75 MHz, CDCl₃) δ 166.10, 160.90, 137.11, 132.57, 131.42, 129.79, 118.99, 116.98, 40 77.48, 76.64, 55.86, 44.30, 31.78 MS (EI, 70 eV, rel. intensity): 229 (100, M⁺).

(PCy₃)₂Cl₂Ru(3-2-methylphenyl-5-methyl-inden-1-ylidene (0.53 mmol) and (1-imidazole-3-propylimino)methyl-phenol (0.53 mmol), silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (50° C.) and stirred for a period of 4 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure.

The reaction mixture was investigated on¹H and³¹P NMR, which revealed quantitative transformation to complex 11B.

Characteristic values of¹H and³¹P: H—C8: 7.25 ppm (d, 1H) and P: 36.95 ppm.

The isolated solid residue provided the catalyst in 75% yield.

(Simes)(PCy₃)Cl₂Ru(3-2-methylphenyl-5-methylphenyl-inden-1-ylidene) (0.51 mmol) and 2-[(2-methylphenylimino)methyl]phenol (1.1 mmol) and silver(I) oxide (0.65 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 5 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure. Addition of 2 mL CH₂Cl₂and an excess of cold pentane precipitate the catalyst as a deep red powder, Yield: 85%.

The reaction mixture was investigated on¹H and³¹P NMR, which revealed quantitative transformation to complex 12.

Characteristic values of¹H: H—C8: 8.11 ppm (d, 1H). (no³¹P NMR peak present in the complex)

The reaction progress has been monitored using H-NMR, in FIG. 1 the reaction progress after 1 h is displayed. It is clear that this is still a mixture of the starting Ru-precursor, the ditopic O,N-ligand, the mono O,N-ruthenium complex and the bis O,N-ruthenium complex. FIG. 2 is Reaction progress after 5 h confirming completion of the reaction.

(SIMes)(2-[(2-methylphenylimino)methyl]phenoxy) (3-2-methylphenyl-5-methyl-inden-1-ylidene)Ru(II)Cl (0.51 mmol) and 2-[(2-methylphenylimino)methyl]phenol (0.52 mmol) and silver(I) oxide (0.32 mmol) were added to a Schlenk flask under argon. Dry THF (20 mL) was transferred to the Schlenk flask and then heated (40° C.) and stirred for a period of 5 h followed by cooling to room temperature. The white precipitate of PCy₃AgCl (byproduct) and excess of AgO₂was removed by filtration. The filtrate was collected in a Schlenk flask and the solvent was removed by evaporation under reduced pressure. Addition of 2 mL CH₂Cl₂and an excess of cold pentane precipitate the catalyst as a deep red powder, Yield: 85%.

The reaction mixture was investigated on¹H and³¹P-NMR, which revealed quantitative transformation to complex 12.

Characteristic values of¹H: H—C8: 8.11 ppm (d, 1H). (no³¹P-NMR peak present in the complex)

Performance of the Catalysts of Present Invention

FIG. 3 is comparison between commercial catalysts N and 5A, 6A and 7A for the ring-closing metathesis of diethyldiallylmalonate (DEDAM) using activation (^ausing catalyst N and chemically activated 5A, 6A and 7A at 0.5 mol %, 20 eq of PhSiCl₃, substrate loading: 0.41 mmol DEDAM, temperature: 20° C., solvent: 0.60 mL CDCl₃, conversion determined by¹H NMR).

Upon chemical activation, complexes 6A and 7A significantly outperform the commercial complex N at ambient temperature.

FIG. 4 is comparison between catalysts F and 5A-7A at a 0.1 mol % loading for the RCM of DEDAM (^ausing catalyst F and chemically activated 5A-7A at 0.1 mol %, 10 eq of PhSiCl₃, substrate loading: 0.41 mmol DEDAM, temperature: 20° C., solvent: 0.60 mL CDCl₃, conversion determined by¹H NMR).

At lower catalyst loadings, catalyst lifetime becomes increasingly important. All of the Schiff base-containing catalysts described herein, upon activation by PhSiCl₃, yield quantitative RCM of DEDAM at a catalyst loading of 0.1 mol % in CDCl₃, at room temperature with the exception of 5A which requires 60° C. In all cases, the performance of the salicylaldimine systems 5A-7A is superior to that of the commercial available complex F.

It is well known that DEDAM-2 is a difficult substrate to ring-close since it bears a methyl group on each double bond which introduce severe sterical hindering for the catalyst.

The catalysts of this invention show 100% conversion at a 5 mol % loading. Decreasing the catalyst loading to 0.5 mol % leads to a TON of 136 for 13 and 110 for 14. These results outperform the previous highest TON of 38 for Mod. 112 (modified Hoveyda catalyst) and represent a 20-fold increase compared with the standard Grubbs 2^ndgeneration catalyst. Therefore, 13 and 14 represent an excellent answer to ‘a major challenge for the design of new more efficient catalysts’.

Conditions: 0.5 mol % catalyst, variable eq of PhSiCl₃, substrate loading: 0.41 mmol DEDAM, temperature: 20° C., solvent: 0.60 mL CDCl₃, conversion determined by¹H NMR.

FIG. 5 is influence of activator amount (from top to bottom the amount decreases from 50 eq. to 0.5 eq PhSiCl₃) on the catalytic performance for RCM of DEDAM.

It is clear that no longer an excess of activator is required to activate the catalysts of this invention and clearly outperforms the systems described in EP 1 577 282; EP 1 757 613. Moreover, an excess of activator is not immediately decomposing the catalyst demonstrating the robustness of the systems.

The required amount was of catalyst was dissolved in a minimum amount of dichloromethane (CH₂Cl₂), and thereafter added to 80 g of DCPD which contains the required amount of activator (here PhSiCl₃was used). The mixture was stirred and the polymerization reaction was monitored as a function of time starting at 20° C. by a thermocouple which was placed inside the reaction mixture to collect the temperature data. catalyst/DCPD: 1/60000.

The catalysts used are 4A, 8A, 9A and 12. For catalyst 4A and 8A the catalyst/activator=1/5 while for the 9A and 12 the catalyst/activator=1/0.5.

FIG. 6 is ROMP of DCPD using catalyst 4A, 8A, 9A and 12 of this invention.

A ruthenium catalysts Verpoort (WO 03/062253) and Telene (WO 2011/009721 A1) comprising one and two bidentate Schiff base ligand respectively have been used as a reference catalyst; see table 3.

It is clear that the catalysts of this invention outperform the catalysts described in WO 2011009721 and (WO 03/062253; Tetrahedron Lett., 2002, 43, 9101-9104; (b) J. Mol. Catal. A: Chern., 2006, 260, 221-226; (c) J. Organomet. Chem., 2006, 691, 5482-5486).

Introducing extra groups, substituents on the indenylidene part of the catalysts result in more steric strain in the molecule which promotes the initiation of the catalyst once it is activated.

All catalysts of this invention show an excellent latency towards DCPD (with 9A a fair latency), they are inactive at room temperature. All catalysts of this invention show an improved stability and are superior to other catalysts used as a reference (T and VP), see table 3.

Upon chemical activation, the catalyst of type I-I, e.g. 12 and 9A, according to the present invention, demonstrate an increased initiation compared to the reference catalyst (T and VP) because it requires only less than 1 equivalent of PhSiCI₃to generate a highly active system. When the ROMP of DCPD is catalysed by the chemically activated VP complex (reference), under the same conditions (less than 1 equivalent of PhSiCI₃) a low catalytic activity was observed.

Moreover the ratio catalyst/monomer is increased with 66% compared to the reference catalysts (T and VP) which clearly stress out their superior performance of the catalysts of the present invention

After charging an NMR tube with the appropriate amount of catalyst dissolved in deuterated solvent (CDCl₃), COD was added. The polymerization reaction was monitored as a function of time at 20° C. by integrating olefinic¹H-signals of the formed polymer (5.38-4.44 ppm) and the consumed monomer (5.58 ppm).

catalyst/COD: 1/3000, catalyst concentration: 0.452 mM.

The catalysts of this invention are superior compared with other catalysts, the obtained TON is at least 2 times higher compared with catalyst VP and even 6 times higher or more compared with the other catalysts.

This example demonstrates the possibility of in-situ activation of the catalysts of this invention. Here 40 g of DCPD in which TiCl₄is present is mixed with 40 g of DCPD in which iPrOH and the catalyst are present. In the total DCPD mixture (80 g) a thermocouple is place to follow the temperature increase during the polymerization. From the plot it follows that all monomers are converted since a high temperature of 200° C. is reached. The ratio DCPD/catalyst/Lewis acid-alcohol=30000/1/10-10 and 30000/1/5-5.

FIG. 7 is ROMP of DCPD using in-situ activation of catalyst 4A.

This excellent results confirms that all kinds of combinations between Lewis acids and RYH molecules can be used for in-situ activation of the catalysts of this invention as described in the description

Subsequent to the RCM or cross-metathesis applications, in order to remove the residual ruthenium in final metathesis products, the reaction mixtures were passed through silica gel (3 g per 0.006 mmol of catalyst 11B) with different eluents (see Table 5). The silica gel can also be introduced directly into the reaction mixture. Complete decolorization was observed within 10 minutes of intense stirring. The ruthenium content of some selected metathesis products were determined by ICP-MS analysis. Using a basic filtration through silica gel, the ruthenium content of the products with an initial ruthenium content of 500 ppm were reduced to 1 ppm.

50 ml of a methyl ester mixture (consisting of 92.0% methyl oleate and 2.9% Methyl linoleate, percentages are based on a calibrated GC-Method) in the presence of 150 ppm of the catalyst (4A) is heated at 50° C. for 1 hour. After completion of the reaction 27% dimethyldiesters and 24% of 9-octadecene is obtained.