Substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones for therapy and halogen-substituted spirocyclic ketoenols

03-02-2015 дата публикации

Номер:

US8946124B2

Автор: BRETSCHNEIDER THOMAS, FISCHER REINER, LEHR STEFAN, GATZWEILER ELMAR, GÖRGENS ULRICH, HÄUSER-HAHN ISOLDE, HEINEMANN INES, VOERSTE ARND

Принадлежит: BRETSCHNEIDER THOMAS, FISCHER REINER, LEHR STEFAN, GATZWEILER ELMAR, GÖRGENS ULRICH, HÄUSER-HAHN ISOLDE, HEINEMANN INES, VOERSTE ARND, BAYER IP GMBH, BAYER INTELLECTUAL PROPERTY GMBH

Контакты:

Номер заявки: 00-14-20120147

Дата заявки: 14-02-2012

The invention relates to novel compounds of the formula (I) in which W, X, Y, Z, A, B, D and G have the meanings given above, to a plurality of processes and intermediates for their preparation, and to their use as pesticides and/or herbicides and/or fungicides. The invention also relates to selective herbicidal compositions comprising, firstly, the halogen-substituted spirocyclic ketoenols and, secondly, a crop plant compatibility-improving compound. The present invention furthermore relates to the boosting of the action of crop protection compositions comprising, in particular, halogen-substituted spirocyclic ketoenols, through the addition of ammonium salts or phosphonium salts and optionally penetrants, to the corresponding compositions, to processes for producing them and to their application in crop protection as pesticides and/or fungicides and/or for preventing unwanted plant growth. The invention also relates to substituted 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-1-azaspiro[4.5]dec-3-en-2-ones of the formula (Ia) for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and therapy of tumor disorders.

CPC - классификация

A A0 A01 A01N A01N4 A01N43 A01N43/A01N43/1 A01N43/12 A01N43/3 A01N43/38 A6 A61 A61K A61K3 A61K31 A61K31/A61K31/4 A61K31/40 A61K31/403 A61K4 A61K45 A61K45/A61K45/0 A61K45/06 A61P A61P3 A61P31 A61P31/A61P31/0 A61P31/04 A61P31/1 A61P31/10 A61P33 A61P33/A61P33/0 A61P33/00 A61P35 A61P35/A61P35/0 A61P35/00 A61P4 A61P43 A61P43/A61P43/0 A61P43/00 A61P5 A61P5/A61P5/2 A61P5/24 C C0 C07 C07C C07C2 C07C22 C07C229 C07C229/C07C229/4 C07C229/48 C07C23 C07C233 C07C233/C07C233/5 C07C233/52 C07C5 C07C57 C07C57/C07C57/5 C07C57/58 C07C6 C07C69 C07C69/C07C69/7 C07C69/75 C07C69/757 C07D C07D2 C07D20 C07D209 C07D209/C07D209/5 C07D209/54 C07D23 C07D235 C07D235/C07D235/0 C07D235/02 C07D3 C07D30 C07D307 C07D307/C07D307/9 C07D307/94

IPC - классификация

A A0 A01 A01N A01N4 A01N43 A01N43/A01N43/0 A01N43/08 A01N43/1 A01N43/12 A01N43/3 A01N43/38 A6 A61 A61K A61K3 A61K31 A61K31/A61K31/4 A61K31/40 A61K31/403 A61K4 A61K45 A61K45/A61K45/0 A61K45/06 A61P A61P3 A61P31 A61P31/A61P31/1 A61P31/10 A61P5 A61P5/A61P5/2 A61P5/24 C C0 C07 C07D C07D2 C07D20 C07D209 C07D209/C07D209/5 C07D209/54 C07D3 C07D30 C07D307 C07D307/C07D307/9 C07D307/94

Цитирование НПИ

"Addition Des Reactifs Nucleophiles Sur La Triple Liason Nitrile", Ann Chim., 1970, t. 5, No. 1, 11-27.
"Amino-Acids of the Cyclohexane Series. Part I.", J. Chem. Soc. 1961, 4372-4379.
"Cyclisierung Von N-Acylalanin- und N-Acylglycinestern", Liebigs Ann. Chem. 1985, 1095-1098.
"D.7.1.5. Reaktionen von Carbonsauren und Carbonsauredarivaten mit Basen", Organikum, Berlin, 1977.
"European Search Report for European Application No. 11154805.3, dated Jun. 24, 2011", 1-2.
"Glossary of Common Names and Abbreviations of Herbicides ", Weed Research, vol. 26, 1986, 441-445.
"Synthesis and Insecticidal Activity of Novel N-Oxydihydropyrolle Derivatives with a Substituted Spirocyclohexyl Group", Biosci. Biotechnol. Ciochem. vol. 67, No. 6, 2003, 1230-1238.
"The use of Herbicides in Potato", Weed Control Handbook, 5, 1968, 101-103.
"Use of Molecular Sieves in the Methyl Esterification of Carboxylic Acids", Chem. Ind. 1968, 1-2.
Baur Peter, "Polydisperse Ethoxylated Fatty Alcohol Surfacants as Accelerators of Cuticular Penetration. 1. Effects of Ethoxy Chain Length and the Size of the Penetrants", Pestic. Sci. vol. 51, 1997, 131-152.
Bhattacharya Bhabatosh, "Isoquinoline Derivatives: part XVIII-Formation of I-Alkyl-(or alkaryl or aryl)-3-methyl-7-chloro-(or 5-chloro)-isoquinolines", Indian J. Chem. 6, 1968, 341-345.
Braun Hans-Peter, "The General Mitochondrial processing Peptidase from Potato is an Integral Part of Cytochrome C Reductase of the Respiratory Chain", The EMBO Journal vol. 11, No. 9, 1992, 3219-3227.
Campbell, Alexander C., "Synthesis of (E)- and (Z)-Pulvinones", J. Chem. Soc. Perkin Trans. I, 1985, 1567-1576.
Chemie der Pflanzenschutzund Schaedlin Gsbekaempfungsmittel vol. 2, 1970, 401-412.
Christou Paul, "Transformation Technology", Trends in Plant Science, vol. 1, No. 12, Dec. 1996.
Edward, John T., "Stereochemistry of the Bucherer-Bergs and Strecker Reactions of 4-tert-Butylcyclohexanone", Can. J. Chem. vol. 53, 1975, 3339-3350.
Fustero Santos, "Solution-, Solid-Phase, and Fluorous Synthesis of B,B-Difluorinated Cyclic Quaternary a-Amino Acid Derivatives: A Comparative Study", Chem. Eur. J., vol. 14, 2008, 7019-7029.
International Search Report for PCT/EP2012/052521 Mailed Jun. 26, 2012.
Klingman Glenn, "5. Surface Active Agents", Weed Control as a Science, 1961, 81-91.
Lieb Folker, "2-(Chlorocarbonyl)-2-Mesitylketene, a new Building Block For the Synthesis of 4-Hydroxy-3-Mesityl Tetronic acids", Tetrahedron vol. 57, 2001, 4133-4137.
Sonnewald Uwe, "Transgenic Tobacco Plants Expressing Yeast-Derived Invertase in Either the Cytosol, Vacuole or Apoplast: a Powerful Tool for Studying Sucrose Metabolism and Sink/Source Interactions", The Plant Journal, vol. 1, No. 1, 1991, 95-106.
Sonntag Norman, "The Reactions of Aliphatic Acid Chlorides", Chemical Reviews, 52, 1953, 237-416.
Suzuki Seikichi, "Studies on Antiviral AgentslV. Biological Activity of Tenuazonic Acid Derivatives", Chem. Pharm. Bull.vol. 15, No. 8, 1967, 1120-1122.
Wolter, Frank P., "rbcS Genes in Solanum Tuberosum: Conservation of Transit Peptide and Exon Shuffling During Evolution", Proc. Natl. Acad. Sci., vol. 85, Feb. 1988, 846-850.

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