СПОСОБ ПЕРЕРАБОТКИ ЖИДКИХ ВЕЩЕСТВ

1. Способ переработки жидких веществ, отличающийся тем, что перерабатываемое жидкое вещество непрерывно промывают жидкостью для промывки в одном или нескольких микрореакторах и/или микросмесителях.2. Способ по п.1, отличающийся тем, что используют микрореактор и/или микросмеситель, внутренний диаметр канала которого составляет, по крайней мере, 50 мкм.3. Способ по п.1, отличающийся тем, что используют микрореактор и/или микросмеситель, внутренний диаметр канала которого составляет, по крайней мере, 100 мкм.4. Способ по п.1, отличающийся тем, что используют микрореактор и/или микросмеситель, внутренний диаметр канала которого максимально составляет 1000 мкм.5. Способ по п.1, отличающийся тем, что используют микрореактор и/или микросмеситель, внутренний диаметр канала которого максимально составляет 3000 мкм.6. Способ по п.1, отличающийся тем, что жидкости направляют через микрореактор и/или микросмеситель ламинарным потоком.7. Способ по п.1, отличающийся тем, что жидкости направляют через микрореактор и/или микросмеситель потоком с числом Рейнольдса <1000.8. Способ по п.1, отличающийся тем, что используют микрореактор и/или микросмеситель, который содержит пассивные смесительные структуры.9. Способ по п.1, отличающийся тем, что используют микрореактор и/или микросмеситель, который состоит из стекла или кремния.10. Способ по п.1, отличающийся тем, что используют микрореактор и/или микросмеситель, который состоит из металла, керамики или эмали.11. Способ по п.1, отличающийся тем, что смесь из жидкого (ценного) вещества и промывной жидкости, вытекающую из микрореактора и/или микросмесителя, направляют в приемник с верхним и нижним сливам

MINIATURISIERTE DIFFERENTIELLE EXTRAKTIONSVORRICHTUNG UND VERFAHREN

Method and apparatus for oil condition monitoring

PROCEDURE AND DEVICE FOR DIFFUSION EXCHANGE BETWEEN NOT MIXABLE LIQUIDS

Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams

High throughput microfluidic device

A microfluidic element comprising at least one pair of plates, at least one of said plates having an open channel distributed on a surface that is adjacent the other plate in the pair. In use, said plates are releasably clamped together so as to form an enclosed, continuous microfluidic channel between the plates that is suitable for the passage of a fluid.

Method and apparatus for diffusive transfer between immiscible fluids

METHOD AND APPARATUS FOR DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS

In order to facilitate diffusive transfer of an entity such as a solute between immiscible fluids and subsequent separation of the liquids without mixing, method and apparatus are disclosed having first and second flow paths (1, 2) carrying first and second immiscible fluids on opposite sides of a foraminous sheet (8) wherein the height of the apertures (10) therein are not greater than 200 micrometers (measured perpendicular to the width of the sheet and to the direction of fluid flow), and a stable interface is formed between the fluids within each aperture, with a significant amount of fluid flow immediately adjacent the interface. Diffusive transfer takes place across the interface, and subsequently the fluids flow away from the region without mixing. The width of the flow paths measured perpendicular to sheet (8) lies between 10 and 500 micrometers. The walls of each aperture may be parallel or tapered.

METHOD AND APPARATUS FOR DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS

In order to facilitate diffusive transfer of an entity such as a solute between immiscible fluids and subsequent separation of the fluids without mixing, method and apparatus are disclosed having first and second fluid flow paths (11, 12) carrying first and second immiscible fluids, the flow paths communicating with one another in an interface region (16) in which the fluids contact one another and a stable open interface is formed. Diffusive transfer takes place across the interface, and subsequently the fluids flow away from the interface without mixing. The width of the flow paths in the interface region measured normal to the interface lies between 10 and 500 micrometres.

EMULSIFYING AND SEPARATING DEVICE FOR LIQUID PHASES

SYSTEMS AND PROCEDURES FOR ON BLOOD BASED THERAPIES WITH DIAPHRAGM LOTS A MICRO FLUID EXCHANGE DEVICE

PROCEDURE FOR DIAPHRAGM LOTS MICRO FLUID EXCHANGE IN A H-FILTER AND A FILTERING OF EXTRACTION LIQUID OUTPUT CURRENTS

EXTRAKTIONSVERFAHREN USING A STATIC MICRO MIXER

Method and apparatus for diffusive transfer between immiscible fluids

Microfabricated differential extraction device and method

PROCEEDED Of EXTRACTION Of AT LEAST ONE COMPOSES Of a LIQUID PHASE INCLUDING/UNDERSTANDING IONIC UNLIQUIDE FUNCTIONALIZES, AND SYSTEM MICROFLUIDIQUE FOR the IMPLEMENTATION OF CEPROCEDE.

La présente invention concerne un procédé d'extraction d'au moins un composé chimique ou biologique d'une phase liquide comprenant au moins un liquide ionique fonctionnalisé, par l'intermédiaire d'un fluide liquide d'extraction (F) qui est immiscible avec le(s)dit(s) liquide(s) ionique(s), et un système microfluidique (10) pour la mise en oeuvre de ce procédé. Le procédé d'extraction selon l'invention comprend un déplacement, sur une surface (12) d'un système microfluidique (10), d'au moins une microgoutte (14) de ladite phase liquide dans un bain d'extraction (20) qui comprend ledit fluide d'extraction et qui est localisé sur ladite surface pour l'obtention en sortie dudit bain, sous l'effet d'un champ électrique, d'un extrait (E) s'éloignant de ladite surface qui est riche en fluide d'extraction et enrichi en ledit ou l'un au moins desdits composé(s), et d'un raffinat (R) évoluant sur ladite surface qui est riche en liquide(s) ionique(s) et appauvri en ledit ou l'un au moins desdits composé ...

METHOD AND APPARATUS FOR DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS

본 발명은 비혼화성 유체 사이의 용질과 같은 물질의 확산 전달 및 혼합 없이 액체의 후속 분리를 촉진시키기 위하여, 구멍(10)의 높이가 200㎛ 미만이고(시트의 폭 및 유체 흐름의 방향에 대해 수직으로 측정됨), 각각의 구멍내의 유체 사이에 경계면이 형성되고 경계면에 바로 인접한 위치에 다량의 유체 흐름가 있는, 소공성 시트(8)의 반대면상에 제 1 및 제 2 비혼화성 유체를 운반시키는 제 1 및 제 2 흐름 경로(1,2)를 갖는 장치 및 방법에 관한 것이다. 확산 전달은 경계면을 횡단하여 일어나고, 후속하여 유체는 혼합 없이 영역으로부터 유동한다. 시트(8)에 대해 수직으로 측정된 흐름 경로의 폭은 10 내지 500㎛이다. 각각의 구멍의 벽은 평행하거나 점점 가늘어진 형태일 수 있다. In order to facilitate subsequent separation of the liquid without diffusion transfer and mixing of materials such as solutes between the immiscible fluids, the present invention provides that the height of the holes 10 is less than 200 μm (perpendicular to the width of the sheet and the direction of fluid flow). Agent for conveying the first and second immiscible fluids on opposite sides of the porosity sheet 8, with an interface formed between the fluid in each hole and a large amount of fluid flow at a location immediately adjacent to the interface. A device and method having a first and second flow paths (1, 2). Diffusion transfer occurs across the interface and subsequently fluid flows out of the region without mixing. The width of the flow path measured perpendicular to the sheet 8 is 10 to 500 μm. The walls of each hole can be parallel or tapered.

SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION FLUID OUTLET STREAMS

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Systems and methods of blood-based therapies having a microfluidic membraneless exchange device

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

Emulgier- und Trennvorrichtung für flüssige Phasen

A device for emulsifying and separating small quantities of miscible, liquid phases essentially comprises a cover plate (2) which can be tightly connected to a base plate (1), microchannels (4, 4a, 5, 6, 6a) in the form of grooves being formed in the inner surface (3, 3a) of the base plate (1) and/or the cover plate (2). In a mixing section, two microchannels (4, 4a) extend in a wave shape, their paths crossing each other several times. In a follow-on separating section they are united in a common microchannel (5), extending in an essentially straight line. The microchannels (4, 4a, 5, 6, 6a), which are otherwise tightly sealed, can be filled and emptied via inlet openings (8, 8a) and outlet openings (9, 9a).

Method and apparatus for oil condition monitoring

A microfluidic system for monitoring lubricant oil condition, comprising a microfluidic device with at least one channel configured to allow a lubricant sample laminar flow through the channel, at least one separating device to separate at least one component from the oil and a detector to detect/measure at least one property of the removed component after separation. The channel may comprise a plurality of inlets and outlets a first to receive the oil and a second to receive a solvent. The separated component may be a metal, a carboxylic acid, an a-alkane insoluble and/or sulphur. The detector may comprise a spectrometer, camera, CCD device, conductivity sensor, capacitance sensor and/or a metal responsive to a chemical analyte, preferable a UV spectrometer. The separation device may be a magnet, a metal based sulphur removal device or preferably a diffusion extractor which may be a H-filter. Also included is a method of monitoring the condition of lubricant oil using such a microfluidic ...

Method and apparatus for oil condition monitoring

PROCEDURE AND VORICHTUNG FUR DIFFUSION EXCHANGE BETWEEN NOT MIXABLE LIQUIDS

PROCEDURE FOR THE EXTRACTION AT LEAST ONE CONNECTION FROM A LIQUID PHASE, WHICH COVERS A IONI LIQUID, AND MICRO-FLUID SYSTEM FOR THE IMPLEMENTATION OF MENTIONED METHOD

METHOD AND APPARATUS FOR DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS

본 발명은 제 1 및 제 2의 비혼화성 유체들간의 공정을 수행하기 위한 방법 및 장치를 제공하는 것으로서, 본 발명의 장치는 제 1 및 제 2 비혼화성 유체의 흐름을 허용하고 각각 자체들의 일부분이 서로 밀접 또는 근접하게 배치되어 안정한 개방 경계면을 형성하고 있는 영역에서 서로 개통-연결되어 있는 제 1 및 제 2 흐름로를 구비하고 있으며, 상기 영역에서 상기 경계 영역의 최소한 제 1 흐름로는 경계면에 대하여 수직으로 10 내지 500 ㎛ 범위에 해당되는 폭을 가진다. The present invention provides a method and apparatus for performing a process between first and second immiscible fluids, wherein the apparatus of the present invention permits the flow of the first and second immiscible fluids and each of which is part of itself. First and second flow paths that are open-connected to each other in an area disposed close to or close to each other to form a stable open interface, wherein at least the first flow path of the boundary area in the area is relative to the interface. Vertically having a width in the range of 10 to 500 μm.

SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of 'small' molecules, 'middle' molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

SEPARATION METHOD

A total solvent use amount is reduced while a final concentration of a specific element of a separation target in a target fluid is reliably decreased to a target value or less. In a separation method, a solvent greater than a theoretical amount of a solvent necessary for decreasing a concentration of a specific element in an extraction remaining liquid supplied from a second extraction stage as an immediately previous stage to the target value is supplied to a third micro channel of a third extraction stage as a final stage, an extraction liquid separated by a third settler of the third extraction stage as the final stage is distributed to a first extraction stage and the second extraction stage, and the extraction liquid distributed to a first micro channel of the first extraction stage and a second micro channel of the second extraction stage are used as solvent. 1. A separation method of separating a specific element from a target fluid by using a separation device configured by connecting three separation stages or more each including an elution portion for eluting the specific element from the target fluid and a settler connected to the elution portion , the separation method comprising:causing the first separation stage among the three separation stages or more connected to one another to elute the specific element from the target fluid to a solvent by bringing the solvent into contact with the target fluid using the elution portion and to separate a fluid derived from the elution portion into an elution fluid as the solvent having the specific element dissolved therein and a dissolved remaining fluid as the target fluid having a decreased concentration of the specific element using the settler;causing each separation stage from the second separation stage to elute the specific element from the dissolved remaining fluid to the solvent by bringing the solvent into contact with the dissolved remaining fluid separated by the settler of the immediately previous ...

Device and method for real-time detection of aeropathogens

Disclosed herein are devices and methods for the real-time detection of aeropathogens. The device includes an aerosampler having an air inlet and at least one collector tube, a microfluidic system which includes a container, piping, a micro-pump for flowing a liquid, and a viral detection chamber. The viral detection chamber has an electrode which may be equipped with functionalized biosensors, a counter electrode, an electronic detection system connectable to the electrodes of the viral detection chamber, and an embedded electronic processing system for processing data from the electronic detection system.

DEVICE AND PROCESS FOR SUBSTANCE SEPARATION IN A MICROSTRUCTURED APPARATUS

SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE

METHOD AND APPARATUS FOR DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS

VERFAHREN UND VORICHTUNG FUR DIFFUSIONSAUSTAUSCH ZWISCHEN NICHT MISCHBARE FLÜSSIGKEITEN

VERFAHREN UND VORICHTUNG FUR DIFFUSIONSAUSTAUSCH ZWISCHEN NICHT MISCHBARE FLÜSSIGKEITEN

SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of 'small' molecules, 'middle' molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

METHOD FOR PREPARING LIQUID SUBSTANCES

The invention concerns a method for preparing liquid substances, whereby the preparation is made in one or several micro-reactors and/or micro-mixers, the liquid substance to be prepared being continuously mixed with a washing liquid in the micro-reactors and/or micro-mixers.

Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams

一种装置、系统和方法用于通过在微流通道内使第一流体和第二流体直接接触而在第一流体和第二流体之间交换成分。流体在通道内以薄层形式流动。其中一种流体被经过过滤器，离开通道，再通过改变流体性能的辅助处理器被再循环。经过再循环的流体被再利用进行进一步交换。过滤器从被再循环的流体中将血细胞排除在外，并防止或限制过滤器的阻塞。辅助处理器通过透析去除代谢废物和水。

DEVICE AND PROCESS OF ESTABLISHMENT OF CONTACT BETWEEN IMMISCIBLE LIQUID PHASES BY THE CENTRIFUGAL FORCE

La présente invention concerne un dispositif et un procédé de mise en contact de phases fluides immiscibles par la force centrifuge, en particulier pour réaliser l'extraction de composés de l'une de ces phases par une autre phase. Ce dispositif comporte au moins une unité de mise en contact (3') qui est apte à être entraînée en rotation autour d'un axe (X'X) et qui comprend une pluralité de cellules (210, A, D) destinées à être parcourues successivement par ces phases dans un sens de circulation donné, chaque cellule étant pourvue de deux canaux d'entrée/ sortie (214 et 215) qui relient de manière fluidique les cellules deux à deux entre elles et qui débouchent dans chaque cellule respectivement par deux orifices d'entrée/ sortie respectivement proximal (214a) et distal (215a) par rapport audit axe. Selon l'invention, pour au moins deux cellules adjacentes (A et D) de ladite au moins une unité, leurs deux orifices proximaux (214a) ou bien distaux (215a) sont reliés directement entre eux par l'un de ces canaux (214 ou 215), de telle sorte que ces phases circulent à travers l'une de ces cellules adjacentes vers ledit axe et à travers l'autre cellule en s'éloignant dudit axe. The present invention relates to a device and a method for contacting immiscible fluid phases by centrifugal force, in particular to carry out the extraction of compounds from one of these phases by another phase. This device comprises at least one contacting unit (3 ') which is adapted to be rotated about an axis (X'X) and which comprises a plurality of cells (210, A, D) intended to be successively traversed by these phases in a given direction of circulation, each cell being provided with two input / output channels (214 and 215) which fluidly connect the cells two by two to each other and which open into each cell respectively by two inlet / outlet ports respectively proximal (214a) and distal (215a) with respect to said axis. According to ...

DEVICE AND PROCEEDED MICROFLUIDIQUE OF TRANSFER OF MATTER BETWEEN TWO IMMISCIBLE PHASES.

Method for the selective extraction of acids, bases and polar salts

A process for the extraction of an unwanted material from a gas or liquid comprising the steps of introducing an extraction liquid into the fluid having an unwanted liquid therein to form a physical microdispersion comprising a plurality of extraction liquid droplets and the fluid, allowing the plurality of extraction liquid droplets to interact with the unwanted component in the fluid, to cause the extraction liquid droplets to be “wetted out” and captured on a porous medium, where the liquid is further contacted by the gas and simultaneously formed into a plurality of coalesceable droplets, coalescing the coalesceable droplets into larger droplets containing the unwanted liquid, and separating the larger droplets containing the unwanted liquid from the fluid.

High throughput microfluidic device

MONOCHLOROTRIFLUOROPROPENE COMPOUNDS AND COMPOSITIONS AND METHODS USING SAME

Various uses of monochlorotrifluoropropenes, in combination with one or more other components, including other fluoroalkenes, hydrocarbons; hydrofluorocarbons (HFCs), ethers, alcohols, aldehydes, ketones, methyl formate, formic acid, water, trans-1,2-dichloroethylene, carbon dioxide and combinations of any two or more of these, in a variety of applications, including as blowing agents, are disclosed.

DEVICE MICROFLUIDIQUE Of EXTRACTION HAS INTERFACE LIQUIDE-LIQUIDE STABILISEE

L'invention porte sur un dispositif microfluidique d'extraction (1) d'analytes d'intérêt d'un liquide porteur (P) dans un liquide solvant (S), les deux liquides (P, S) formant une interface (2) entre des micro-piliers (32) d'une chambre d'extraction (30). Selon l'invention, le liquide porteur (P) forme un angle de contact θ1 sur les micro-piliers (32) d'une part, et un angle de contact θ2 sur la paroi supérieure (21) d'autre part, lesdits angles de contact vérifiant la relation 45°≤ (θ1+θ2) /2 ≤135°.

SOLVENT EXTRACTION DEVICE WITH COMPENSATION FOR VARIATIONS OF MELT VISCOSITIES AND A PROCESS THEREOF

L'invention se situe dans le domaine de la chimie séparative par partage par solvant. Elle concerne un système d'extraction par solvant en écoulements parallèles. Selon l'invention, le système d'extraction (10) comprend : ▪ un dispositif d'échange fluidique (20) comprenant un canal d'échange fluidique (213) agencé pour canaliser en parallèle deux phases liquides en les mettant en contact l'une avec l'autre, ▪ des capillaires de sortie (33, 34) connectés chacun à un orifice de sortie du dispositif d'échange fluidique, les longueurs des capillaires de sortie (33, 34) étant déterminées de sorte que le rapport de la longueur LB,capS du deuxième capillaire de sortie sur la longueur LA,capS du premier capillaire de sortie soit égal au rapport du débit QA de la phase liquide A sur le débit QB de la phase liquide B multiplié par le rapport de la viscosité µA,capS de la phase liquide A en sortie du canal d'échange fluidique sur la viscosité µB,capS de la phase liquide B en sortie du canal d'échange fluidique, de façon à compenser les variations de viscosités des phases liquides. The invention is in the field of separative solvent partition chemistry. It relates to a solvent extraction system in parallel flows. According to the invention, the extraction system (10) comprises: a fluid exchange device (20) comprising a fluid exchange channel (213) arranged for channeling two liquid phases in parallel by putting them into contact with each other; one with the other, ▪ outlet capillaries (33, 34) each connected to an outlet of the fluid exchange device, the lengths of the outlet capillaries (33, 34) being determined so that the ratio of the length LB, capS of the second outlet capillary on the length LA, capS of the first outlet capillary is equal to the ratio of the flow rate QA of the liquid phase A to the flow rate QB of the liquid phase B multiplied by the ratio of the viscosity μA, capS of the liquid phase A at the outlet of the ...

METHOD AND APPARATUS FOR PRODUCING MICRO EMULSIONS

This invention relates to preparation of micro emulsions having a controlled size. It provides methods, measures, apparatus and products produced by the methods. The method is particularly suitable for preparing micro emulsions of water containing one or more ionic species in an oil and/or dense fluid phase such as CO2 containing fluids under near or supercritical conditions, thereby enabling the use of said dense fluids as solvents for extraction of ionic species, as nano-reactor templates and/or as a car–rier for further processing such as deposition on a solid material and/or in a process for producing fine particles, such as particles in the nano- or micrometer range.

EXTRACTION METHOD USING A STATIC MICROMIXER

The invention relates to a method for extracting at least one substance from a fluid starting material by means of a suitable extraction agent, using a static micromixer for mixing the starting material with the extraction agent. Said static micromixer comprises plate-shaped components, the plate (1) being provided with at least one inlet (2) for supplying at least one fluid flow into a connection channel (3) located in the plate plane, and at least one outlet (4) for discharging the fluid flow into a mixing region (5) located in the plate plane. Said inlet (2) communicates with the outlets (4) by means of the connection channel (3) located in the plate plane, and the connection channel is split into at least two partial channels (7), by means of microstructural units (6), before ending in the mixing region (5). According to the invention, the widths of the partial channels are measured in the millimetre to submillimetre range and are smaller than the width of the mixing region (5).

SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION OUTLET STREAMS

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

MONOCHLOROTRIFLUOROPROPENE COMPOUNDS AND COMPOSITIONS AND MEHTODS USING SAME

Various uses of monochlorotrifluoropropenes, in combination with one or more other components, including other fluoroalkenes, hydrocarbons; hydrofluorocarbons (HFCs), ethers, alcohols, aldehydes, ketones, methyl formate, formic acid, water, trans-1,2-dichloroethylene, carbon dioxide and combinations of any two or more of these, in a variety of applications, including as blowing agents, are disclosed.

METHOD FOR PURIFYING PIGMENT DISPERSION, PIGMENT DISPERSION, INK SET, LIQUID DROPLET DISCHARGE APPARATUS AND INK TANK FOR INK-JET RECORDING

【課題】従来の精製処理では除去し切れないインク作製用顔料分散液やインクなどの顔料分散液中に含まれる不純物を除去する顔料分散液精製方法を提供すること。 【解決手段】 微小空間内にて、不純物および顔料を含む未精製顔料分散液と、抽出液体とを液−液界面接触させることにより、前記未精製顔料分散液中の不純物を前記抽出液体に抽出させて除去する精製工程を有する顔料分散液精製方法。 【選択図】図２

VERFAHREN UND VORRICHTUNG FÜR DIFFUSIONSAUSTAUSCH ZWISCHEN NICHT MISCHBARE FLÜSSIGKEITEN

Extraktionsverfahren unter Verwendung eines statischen Mikromischers

Electrosynthesis of organic compounds

METHODS AND DEVICES FOR MICROFLUIDIC EXTRACTION

SYSTEMS AND METHODS OF MICROFLUIDIC MEMBRANELESS EXCHANGE USING FILTRATION OF EXTRACTION FLUID OUTLET STREAMS

A device, system and method for exchanging components between first and s econd fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter up on exiting the channel and is recycled through a secondary processor which c hanges the fluid's properties. The recycled fluid is reused for further exch ange. The filter excludes blood cells from the recycled fluid and prevents o r limits clogging of the filter. The secondary processor removes metabolic w aste and water by diafiltration.

SYSTEMS AND METHODS OF BLOOD-BASED THERAPIES HAVING A MICROFLUIDIC MEMBRANELESS EXCHANGE DEVICE

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of 'small' molecules, 'middle' molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

MONOCHLOROTRIFLUOROPROPENE COMPOUNDS AND COMPOSITIONS AND METHODS USING SAME

Various uses of monochlorotrifluoropropenes, in combination with one or more other components, including other fluoroalkenes, hydrocarbons; hydrofluorocarbons (HFCs), ethers, alcohols, aldehydes, ketones, methyl formate, formic acid, water, trans-1,2-dichloroethylene, carbon dioxide and combinations of any two or more of these, in a variety of applications, including as blowing agents, are disclosed.

SOLVENT EXTRACTION DEVICE WITH COMPENSATION FOR VARIATIONS OF MELT VISCOSITIES AND A PROCESS THEREOF

L'invention se situe dans le domaine de la chimie séparative par partage par solvant. Elle concerne un système d'extraction par solvant en écoulements parallèles. Selon l'invention, le système d'extraction (10) comprend : ▪ un dispositif d'échange fluidique (20) comprenant un canal d'échange fluidique (213) agencé pour canaliser en parallèle deux phases liquides en les mettant en contact l'une avec l'autre, ▪ des capillaires de sortie (33, 34) connectés chacun à un orifice de sortie du dispositif d'échange fluidique, les longueurs des capillaires de sortie (33, 34) étant déterminées de sorte que le rapport de la longueur LB,capS du deuxième capillaire de sortie sur la longueur LA,capS du premier capillaire de sortie soit égal au rapport du débit QA de la phase liquide A sur le débit QB de la phase liquide B multiplié par le rapport de la viscosité µA,capS de la phase liquide A en sortie du canal d'échange fluidique sur la viscosité µB,capS de la phase liquide B en sortie du canal d'échange fluidique, de façon à compenser les variations de viscosités des phases liquides. The invention is in the field of separative solvent partition chemistry. It relates to a solvent extraction system in parallel flows. According to the invention, the extraction system (10) comprises: a fluid exchange device (20) comprising a fluid exchange channel (213) arranged for channeling two liquid phases in parallel by putting them into contact with each other; one with the other, ▪ outlet capillaries (33, 34) each connected to an outlet of the fluid exchange device, the lengths of the outlet capillaries (33, 34) being determined so that the ratio of the length LB, capS of the second outlet capillary on the length LA, capS of the first outlet capillary is equal to the ratio of the flow rate QA of the liquid phase A to the flow rate QB of the liquid phase B multiplied by the ratio of the viscosity μA, capS of the liquid phase A at the outlet of the ...

HIGH THROUGHPUT MICROFLUIDIC DEVICE

A microfluidic element comprising at least one pair of plates, at least one of said plates having an open channel distributed on a surface that is adjacent the other plate in the pair. In use, said plates are releasably clamped together so as to form an enclosed, continuous microfluidic channel between the plates that is suitable for the passage of a fluid.

SURFACTANT

A surfactant of formula (I): 1. A surfactant of formula (I):{'br': None, 'sub': 1', 'a', '2', 'b', '2', 'c, 'A-(L)-(CH)-(L)-X \u2003\u2003(I)'}whereinA is a perfluoropolyether;{'sub': 1', '1-6, 'Lis CONR′, wherein R is selected from H and Calkyl;'}a is 0 or 1;b is 0 or an integer between 1 and 10;{'sub': '2', 'Lis a linking group;'}c is 0 or 1; andX is a charged group.2. A surfactant as claimed in claim 1 , wherein said perfluoropolyether comprises any one of (a) a repeat unit of the formula —[CF(CF)CFO]— claim 1 , wherein m is a positive integer claim 1 , (b) a unit of the formula —[CFCFO]—[CF (CF)CFO]— claim 1 , wherein m and n are each 0 or a positive integer claim 1 , with the proviso that m and n are not both 0; and (c) CFCFCFO—[CF(CF)CFO]—CF(CF)— claim 1 , wherein m is a positive integer.3. (canceled)4. (canceled)5. A surfactant as claimed in claim 2 , wherein m is an integer from 1 to 100.6. A surfactant as claimed in claim 1 , wherein a is 0.7. A surfactant as claimed in claim 1 , wherein a is 1 and Lis CONH or CONCH.8. A surfactant as claimed in claim 1 , wherein b is an integer from 1 to 10 claim 1 , more preferably 2 to 3.9. A surfactant as claimed in claim 1 , wherein c is 0.10. A surfactant as claimed in claim 1 , wherein X is a positively charged group.12. (canceled)13. (canceled)14. (canceled)16. A surfactant as claimed in claim 1 , wherein X comprises a zwitterionic group.18. (canceled)19. (canceled)20. (canceled)22. A surfactant as claimed in claim 1 , wherein X comprises a negatively charged group.24. (canceled)25. (canceled)26. (canceled)33. A composition comprising a surfactant as claimed in claim 1 , preferably wherein said composition further comprises a multicharged compound or polymer claim 1 , and more preferably claim 1 , wherein said multicharged compound or polymer is oppositely charged to said surfactant.34. (canceled)35. (canceled)36. (canceled)37. (canceled)38. The composition as claimed in claim 33 , wherein the composition is an ...

Electrosynthesis of organic compounds

Disclosed is a process for the electrochemical transformation of a compound to form a product, the process comprising (i) effecting the transformation in the presence of an electrolyte comprising at least one room temperature ionic liquid, wherein the ionic liquid is air-stable and moisture-stable, (ii) recovering the product, and optionally (iii) recovering the ionic liquid. The process can be used to effect the electrochemical transformation of a wide range of organic compounds.

Method for preparing liquid substances

Electrosynthesis of organic compounds

DEVICE FOR EXTRACTING BIOLOGICAL MOLECULES FROM TISSUE SPECIMENS

The present invention provides a non-destructive macromolecules extraction (NDME) device for extracting high quantity of biological molecules (including, but not limited to, proteins, DNA, and/or RNA) from tissue specimens (including, but not limited to, fresh or fixed tissue sections, homogenized tissues, and cell cultures), while preserving the morphology and antigenicity of the tissue. The device contains a base, a slide cover, and a thermal control device. The tissue specimen is placed onto the base. The slide cover is mounted to the base to form a space where an extraction solution can be added. The device optionally contains a chamber cover over the slide cover. The chamber cover and the slide cover forms a reaction chamber where a steam is infused to maintain the humidity of the tissue. The extraction solution contains a detergent. The present invention also provides a method for extracting the same.

Micro-fluid unit for transferring matter between two non-miscible phases uses natural electrical forces to move at least one microdrop

Procédé de transfert de matière d'au moins un soluté (S) entre une première phase liquide (P1) et une deuxième phase fluide (P2), immiscible avec la première, caractérisé en ce qu'il comporte le déplacement, dans un dispositif microfluidique et à l'aide de forces de nature électrique (électromouillage ou diélectrophorèse), d'au moins une gouttelette (G) de ladite première phase fluide (P1) à l'intérieur d'un espace (50) rempli par ladite deuxième phase fluide (P2). De préférence, le déplacement de ladite gouttelette (G) à l'aide desdites forces de nature électrique est effectué le long d'une trajectoire (TG) entre un point d'injection (22) de ladite gouttelette (G) dans ledit dispositif microfluidique et une zone d'extraction et/ou d'analyse (30), ladite trajectoire (TG) étant déterminée de telle manière que ladite gouttelette (G) effectue un balayage d'une fraction significative dudit espace (50) rempli par ladite deuxième phase fluide (P2). Le procédé peut comporter une étape de transfert ...

TWO-PHASE ELECTROEXTRACTION FROM MOVING PHASES

VERFAHREN UND VORRICHTUNG FÜR DIFFUSIONSAUSTAUSCH ZWISCHEN NICHT MISCHBARE FLÜSSIGKEITEN

MICROFLUIDIC DEVICE FOR EXTRACTING LIQUID-LIQUID INTERFACE STABILIZED

DEVICE AND PROCESS OF ESTABLISHMENT OF CONTACT BETWEEN IMMISCIBLE LIQUID PHASES BY THE CENTRIFUGAL FORCE

EMULSIFYING AND SEPARATING DEVICE FOR LIQUID PHASES

A device for emulsifying and separating small quantities of miscible, liquid phases essentially comprises a cover plate (2) which can be tightly connected to a base plate (1), microchannels (4, 4a, 5, 6, 6a) in the form of grooves being formed in the inner surface (3, 3a) of the base plate (1) and/or the cover plate (2). In a mixing section, two microchannels (4, 4a) extend in a wave shape, their paths crossing each other several times. In a follow-on separating section they are united in a common microchannel (5), extending in an essentially straight line. The microchannels (4, 4a, 5, 6, 6a), which are otherwise tightly sealed, can be filled and emptied via inlet openings (8, 8a) and outlet openings (9, 9a).

Systems and methods of blood-based therapies having a microfluidic membraneless exchange device

The present invention is directed to devices, systems and methods for removing undesirable materials from a sample fluid by contact with a second fluid. The sample fluid flows as a thin layer adjacent to, or between, concurrently flowing layers of the second fluid, without an intervening membrane. In various embodiments, a secondary separator is used to restrict the removal of desirable substances and effect the removal of undesirable substances from blood. The invention is useful in a variety of situations where a sample fluid is to be purified via a diffusion mechanism against an extractor fluid. Moreover, the invention may be used for the removal of components from a sample fluid that vary in size. When blood is the sample fluid, for example, this may include the removal of ‘small’ molecules, ‘middle’ molecules, macromolecules, macromolecular aggregates, and cells, from the blood sample to the extractor fluid.

DEVICE AND METHOD FOR SEPARATION OF COMPONENTS OF A SAMPLE

Emulsifying and separating device for liquid phases

Method and apparatus for diffusive transfer between immiscible fluids

RECOVERY OF AQUEOUS HYDROGEN PEROXIDE IN AUTO-OXIDATION H2O2PRODUCTION

Hydrogen peroxide produced in an auto-oxidation process is recovered from H2O2-containing organic solution via liquid-liquid extraction with an aqueo us medium in a device having elongated channels, with a small cross-sectiona l dimension, that facilitate efficient extraction of aqueous hydrogen peroxi de from the organic solution.

Three-way combined type micro-channel device for forming stable annular flow

PROCEEDED Of EXTRACTION Of AT LEAST ONE COMPOSES Of a LIQUID PHASE INCLUDING/UNDERSTANDING an IONIC LIQUID FUNCTIONALIZES, AND SYSTEM MICROFLUIDIQUE FOR the IMPLEMENTATION OF THIS PROCESS.

Method and apparatus for oil condition monitoring

MICROFABRICATED DIFFERENTIAL EXTRACTION DEVICE AND METHOD

This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers.

Method and apparatus for diffusive transfer between immiscible fluids

sistemas e métodos de troca sem membrana microfluida usando filtração da extração de correntes de saìda de fluido.

Liquid treatment, comprises mixing the liquid with a washing fluid in a micro-reactor or mixer, and then feeding the mixture to a container with upper and lower drain lines to separate the phases

A process for treating liquids is carried out in one or more micro-reactors and/or micro-mixers. The liquid to be treated is continuously mixed with a washing fluid, and the liquid / washing liquid mixture flows into a container with upper and lower drain lines after it leaves the reactor and/or mixer.

High throughput microfluidic device

A microfluidic element comprising at least one pair of plates, at least one of said plates having an open channel distributed on a surface that is adjacent the other plate in the pair. In use, said plates are releasably clamped together so as to form an enclosed, continuous microfluidic channel between the plates that is suitable for the passage of a fluid.

Extraction of metals

A process for extracting a target metal ion from an aqueous feedstock containing, inter alia, the target metal ion. The process comprises providing said feedstock and contacting the feedstock with a room temperature ionic liquid (RTIL) that is substantially free of an extraneous organic extractant under liquid-liquid extraction conditions for a time sufficient to allow transfer of at least some of the target metal ions from the feedstock to the RTIL. The RTIL is then separated from the feedstock and the target metal ions are recovered from the RTIL.

Film scratching type rotary micro-channel enhanced extraction equipment and application thereof

Device for extracting biological molecules from tissue specimens and methods for preparing the same

The present invention provides a non-destructive macromolecules extraction (NDME) device for extracting high quantity of biological molecules (including, but not limited to, proteins, DNA, and/or RNA) from tissue specimens (including, but not limited to, fresh or fixed tissue sections, homogenized tissues, and cell cultures), while preserving the morphology and antigenicity of the tissue. The device contains a base, a slide cover, and a thermal control device. The tissue specimen is placed onto the base. The slide cover is mounted to the base to form a space where an extraction solution can be added. The device optionally contains a chamber cover over the slide cover. The chamber cover and the slide cover forms a reaction chamber where a steam is infused to maintain the humidity of the tissue. The extraction solution contains a detergent. The present invention also provides a method for extracting the same.

ELECTROSYNTHESIS OF ORGANIC COMPOUNDS

Disclosed is a process for the electrochemical transformation of a compound to form a product, the process comprising (i) effecting the transformation in the presence of an electrolyte comprising at least one room temperature ionic liquid, wherein the ionic liquid is air-stable and moisture-stable, (ii) recovering the product, and optionally (iii) recovering the ionic liquid. The process can be used to effect the electrochemical transformation of a wide range of organic compounds.

Extraction of metals

A process for extracting a target metal ion from an aqueous feedstock containing, inter alia, the target metal ion. The process comprises providing said feedstock and contacting the feedstock with a room temperature ionic liquid (RTIL) that is substantially free of an extraneous organic extractant under liquid-liquid extraction conditions for a time sufficient to allow transfer of at least some of the target metal ions from the feedstock to the RTIL. The RTIL is then separated from the feedstock and the target metal ions are recovered from the RTIL.

Surfactant

Component transfer processing method and component transfer processing device

A gas transfer processing method includes: transferring gas to an inside or an outside of an absorption liquid within respective processing flow paths while circulating the absorption liquid through the respective processing flow paths; after the gas transferring, separating a mixed fluid including the absorption liquid discharged from outlets of the respective processing flow paths and gas by respective separation headers into the absorption liquid and the gas; and circulating the absorption liquid separated in the separating by returning the separated absorption liquid from the separation headers to inlets of the respective processing flow paths through respective recirculation lines, thus introducing the absorption liquid to the respective processing flow paths. The process promotes transfer of a target component to an absorption liquid, while enabling execution of a component transfer process by compact equipment.

Microfluidic device and process for mass transfer between two immiscible phases

Procédé de transfert de matière d'au moins un soluté (S) entre une première phase liquide (P1) et une deuxième phase fluide (P2), immiscible avec la première, caractérisé en ce qu'il comporte le déplacement, dans un dispositif microfluidique et à l'aide de forces de nature électrique (électromouillage ou diélectrophorèse), d'au moins une gouttelette (G) de ladite première phase fluide (P1) à l'intérieur d'un espace (50) rempli par ladite deuxième phase fluide (P2). De préférence, le déplacement de ladite gouttelette (G) à l'aide desdites forces de nature électrique est effectué le long d'une trajectoire (TG) entre un point d'injection (22) de ladite gouttelette (G) dans ledit dispositif microfluidique et une zone d'extraction et/ou d'analyse (30), ladite trajectoire (TG) étant déterminée de telle manière que ladite gouttelette (G) effectue un balayage d'une fraction significative dudit espace (50) rempli par ladite deuxième phase fluide (P2). Le procédé peut comporter une étape de transfert ...

Extraction of metals

성분 이동 처리 방법 및 성분 이동 처리 장치

... 콤팩트한 설비로 성분 이동 처리를 실시할 수 있도록 하면서, 흡수액에 대한 대상 성분의 이동을 촉진한다. 가스 이동 처리 방법은, 각 처리 유로(31, 61)에 흡수액을 유통시키면서 그 각 처리 유로(31, 61) 내에서 흡수액의 내외로 가스를 이동시키는 가스 이동 공정과, 가스 이동 공정 후, 각 처리 유로(31, 61)의 출구(31c, 61c)로부터 배출된 흡수액과 가스의 혼합 유체를 대응하는 분리 헤더(23, 43)에 있어서 흡수액과 가스로 기액 분리하는 분리 공정과, 분리 공정에서 분리된 흡수액을 분리 헤더(23, 43)로부터 대응하는 재순환 라인(26, 46)을 통하여 각 처리 유로(31, 61)의 입구(31a, 61a)로 되돌려서 그들 각 처리 유로(31, 61)에 도입하는 순환 공정을 구비한다.

METHOD AND APPARATUS FOR PRODUCING MICRO EMULSIONS

This invention relates to preparation of micro emulsions having a controlled size. It provides methods, measures, apparatus and products produced by the methods. The method is particularly suitable for preparing micro emulsions of water containing one or more ionic species in an oil and/or dense fluid phase such as CO2 containing fluids under near or supercritical conditions, thereby enabling the use of said dense fluids as solvents for extraction of ionic species, as nano-reactor templates and/or as a car–rier for further processing such as deposition on a solid material and/or in a process for producing fine particles, such as particles in the nano- or micrometer range.

TWO-PHASE ELECTROEXTRACTION FROM MOVING PHASES

The present invention relates to a process for the electro extraction of molecules from a moving fluid donor phase into an acceptor phase, comprising the steps of: providing an electrically conductive donor phase moving at a first flow velocity and in electrically conductive contact with a first electrode, providing an electrically conductive acceptor phase in direct contact and immiscible with the donor phase, in electrically conductive contact with a second electrode;and providing a supporting or confining phase guide pattern to keep a defined interface between donor phase and acceptor phase, and (d) applying an electrical field between the first and the second electrode.

DEVICE AND PROCESS FOR SUBSTANCE SEPARATION IN A MICROSTRUCTURED APPARATUS

The invention relates to a device for separation of substance mixtures on the micro scale. The invention further relates to a process for separating substance mixtures using the inventive device. The device is a device for separating substance mixtures and for performing chemical reactions between immiscible fluid media on the micro scale, comprising a first channel plate with at least one first process channel for a first fluid medium, an inlet and an outlet, and a connecting or distributing channel in each case, which connects the inlet to the first process channel, and a further connecting or distributing channel which connects the first process channel to the outlet, a second channel plate with at least one second process channel for a second fluid medium immiscible with the first, an inlet and an outlet, and a connecting or distributing channel in each case, which connects the inlet to the second process channel, and a further connecting or distributing channel which connects the second ...

CHEMICAL TREATMENT CARTRIDGE AND METHOD OF USING SAME

There are provided a chemical treatment cartridge capable of easily executing a process for separating constituents from each other, and a method of using the same. The chemical treatment cartridge for transferring liquids contained therein due to deformation occurring thereto upon application of an external force thereto, thereby causing chemical treatment to proceed, wherein the cartridge has an interior comprising an empty space for determining a sequence for the chemical treatment. There are formed, in the interior of the cartridge, a well for receiving a sample from outside and another well where a separation solvent for separating an object constituent contained in the sample as received is mixed with the sample, thereby separating the object constituent contained in the sample from other constituents.

Method and apparatus for diffusive transfer between immiscible fluids

3D printing multi-duct micro-reactor and application thereof

추출 방법

... 추출 방법은, 각 단의 추출기의 유로에 원료 유체와 추제를 유통시키면서 그 원료 유체로부터 추제로 특정 성분을 추출시키는 추출 공정과, 각 단의 상기 추출기의 상기 유로에 있어서 원료 유체로부터의 상기 특정 성분의 추출이 추출 평형에 도달하기 전에 그 유로로부터 원료 유체와 추제의 혼합 유체를 도출하는 도출 공정과, 각 단의 상기 추출기의 상기 유로로부터 도출한 상기 혼합 유체를 각각 원료 유체와 추제로 분리하는 분리 공정과, 각 단의 상기 추출기의 상기 유로로부터 도출되어 상기 분리 공정에서 분리된 각 원료 유체를 다음 단의 상기 추출기의 상기 유로로 공급하는 원료 유체 공급 공정과, 특정 단의 상기 추출기의 상기 유로로부터 도출되어 상기 분리 공정에서 분리된 원료 유체를 상기 특정 단의 다음 단의 상기 추출기의 상기 유로로 공급하기 전에, 그 원료 유체의 pH를 상기 추출 공정에서의 상기 특정 성분의 추출에 수반하여 발생하는 원료 유체의 pH의 변화를 되돌리도록 조정하는 pH 조정 공정을 구비한다.

Microfluidic extraction device having a stabilized liquid/liquid interface

A microfluidic device for extraction of analytes of interest from a carrier liquid in a liquid solvent, the two liquids forming an interface between micro-pillars in an extraction chamber. The carrier liquid forms a wetting angle θ1 on the micro-pillars and a bottom wall of the extraction chamber, and a wetting angle θ2 on a top wall, the wetting angles satisfying equation 45°≦(θ1+θ2)/2≦135°.

SEPARATION METHOD AND SEPARATION DEVICE

A separation method performs steps continuously and leads a solvent in which a separation object component is dissolved and a remaining fluid out of settlers under a separated state. The method includes leading a light fluid with a smaller specific gravity within the fluid in which the specific component is dissolved at the dissolution step and the remaining fluid out of settlers through upper side leading paths, and leading a heavy fluid with a larger specific gravity within the fluid in which the specific component is dissolved and the remaining fluid out of the settlers through lower side leading paths. A flow rate of the light fluid is controlled such that the height position of an interface between the light fluid and the heavy fluid within the settlers is maintained between the height position of connection parts of the upper side leading paths and the height position of connection parts of the lower side leading paths to the settlers. 1. A separation method for separating a specific component from the object fluid by dissolving the specific component in a solvent from the object fluid containing the specific component , comprising the steps of:dissolving the specific component in the solvent from the object fluid within microchannels by feeding the object fluid and the solvent in a state of a slag flow or a two-layer flow to the microchannels;introducing the fluid discharged from the microchannels into settlers and separating the fluid into a fluid comprising the solvent in which the specific component is dissolved and a remaining fluid by a specific gravity difference within the settlers;leading a light fluid which is one fluid with a smaller specific gravity among the fluid in which the specific component is dissolved and the remaining fluid out of the settlers through upper side leading paths connected to the settlers and leading a heavy fluid which is one fluid with a larger specific gravity among the fluid in which the specific component is dissolved and ...

Microfluidics separation method and system thereof

A microfluidic system for separating an analyte from a sample fluid including a series of fluidic channels including at least one first region and at least one second region. The first region includes a plurality of L-nodes, which connects to each other in series. The second region includes a plurality of R-nodes, which connects to each other in series. The first region is configured to trigger at least about one lamination process cycle for both the sample fluid and the buffer fluid and the second region is configured to trigger at least about one reverse lamination process cycle for both the sample fluid and the buffer fluid, whereby the lamination process cycle and the reverse lamination process cycle causes the analyte to diffuse to the buffer fluid from the sample fluid. A method for separating the analyte is also disclosed.

TWO-PHASE ELECTROEXTRACTION FROM MOVING PHASES

The present invention relates to a process for the electro extraction of molecules from a moving fluid donor phase into an acceptor phase, comprising the steps of: providing an electrically conductive donor phase moving at a first flow velocity and in electrically conductive contact with a first electrode, providing an electrically conductive acceptor phase in direct contact and immiscible with the donor phase, in electrically conductive contact with a second electrode; and providing a supporting or confining phase guide pattern to keep a defined interface between donor phase and acceptor phase, and (d) applying an electrical field between the first and the second electrode. 1. A process for the electroextraction of compounds from a moving fluid donor phase into an acceptor phase , comprising the steps of:a) providing an electrically conductive donor phase moving at a first flow velocity and in electrically conductive contact with a first electrode,b) providing an electrically conductive acceptor phase in direct contact and immiscible with the donor phase, in electrically conductive contact with a second electrode; andc) providing a supporting or confining phase guide pattern to keep a defined interface between donor phase and acceptor phase, and(d) applying an electrical field between the first and the second electrode.2. A process according to claim 1 , wherein the acceptor phase is moving co-directionally with the donor phase at a second flow velocity lower than the first flow velocity claim 1 , preferably stagnant.3. A process according to any one of the previous claims claim 1 , wherein the donor and/or acceptor phase remain immiscible during the time scale and under the conditions of the process.4. A process according to any one of the previous claims claim 1 , wherein the electrical field is applied sufficiently high and in a sufficiently long period of time to allow at least part of the analyte compounds to migrate from the donor phase to the acceptor phase ...

EXTRACTION METHOD

An extracting method includes: an extracting step of extracting a specific component from a material fluid to an extraction agent while allowing the material fluid and the extraction agent to flow in a channel of the extraction unit for each stage; an outflowing step of outflowing a mixture fluid from the channel of the extraction unit for each stage before the extraction of the specific component reaches an extraction equilibrium; and a pH regulating step of regulating the pH of the material fluid separated in a separating step after flowing out of the channel of the extraction unit for a predetermined stage so as to cause a reverse change from a change caused in the pH of the material fluid in the extracting step, before the material fluid is introduced into the channel of the extraction unit for a stage succeeding to the predetermined stage. 1. An extracting method , comprising:extracting a specific component from a material fluid to an extraction agent by using an extracting system, which comprises a plurality of extraction units respectively provided for a plurality of stages, wherein each extraction has a channel configured for extraction and connected with one another to allow at least a part of the fluid flown out of the channel of one of the plurality of the extraction units for any one stage of the plurality of stages to be conveyed to the channel of one of the plurality of the extraction units for a stage succeeding to the any one stage,while allowing the material fluid and the extraction agent to flow in the channel of the extraction unit for each of the stages;outflowing a mixture fluid containing the material fluid and the extraction agent from the channel of the extraction unit for each of the stages before extraction of the specific component from the material fluid reaches an extraction equilibrium in the channel of the extraction unit for each of the stages;separating the mixture fluid flown out of the channel of the extraction unit for each of the ...

EXTRACTION OF METALS

A process for extracting a target metal ion from an aqueous feedstock containing, inter alia, the target metal ion. The process comprises providing said feedstock and contacting the feedstock with a room temperature ionic liquid (RTIL) that is substantially free of an extraneous organic extractant under liquid-liquid extraction conditions for a time sufficient to allow transfer of at least some of the target metal ions from the feedstock to the RTIL. The RTIL is then separated from the feedstock and the target metal ions are recovered from the RTIL. 2. (canceled)3. The process according to claim 1 , wherein the process also comprises treating the aqueous feedstock with a material comprising inorganic anions prior to contact with the RTIL.4. The process according to claim 3 , wherein the inorganic anions comprise a halide ion selected from iodide claim 3 , bromide claim 3 , chloride claim 3 , and fluoride.5. (canceled)6. (canceled)7. (canceled)8. The process according to claim 4 , wherein the halide ion comprises chloride and the process comprises treating the aqueous feedstock with HCl to increase the chloride concentration in the aqueous feedstock prior to contact with the RTIL.9. The process according to claim 8 , wherein the aqueous feedstock is treated with 0.02M HCl claim 8 , 0.1M HCl claim 8 , 2M HCl claim 8 , 3M HCl or 7M HCl.10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. The process according to claim 4 , wherein the halide comprises chloride and the process comprises treating the aqueous feedstock with KCl to increase the chloride concentration in the aqueous feedstock prior to contact with the RTIL.15. The process according to claim 14 , wherein the aqueous feedstock is treated with 3M Kcl.16. The process according to claim 1 , wherein the cationic component of the RTIL is selected from the group consisting of: imidazolium claim 1 , piperidinium claim 1 , pyrrolidiunium claim 1 , ammonium and a phosphonium.17. (canceled)18. (canceled)19. ( ...

RECOVERY OF AQUEOUS HYDROGEN PEROXIDE IN AUTO-OXIDATION H202 PRODUCTION

Hydrogen peroxide produced in an auto-oxidation process is recovered from HO—containing organic solution via liquid-liquid extraction with an aqueous medium in a device having elongated channels, with a small cross-sectional dimension, that facilitate efficient extraction of aqueous hydrogen peroxide from the organic solution. 1. A method for the recovery of hydrogen peroxide produced in an auto-oxidation process comprising contacting a HO-containing organic solution in an auto-oxidation process with an aqueous extraction medium in a device with elongated channels having at least one cross sectional dimension within the range of from about 5 microns to about 5 mm , to effect liquid-liquid extraction of hydrogen peroxide from the organic solution into the aqueous medium , and thereafter separating the aqueous medium containing extracted hydrogen peroxide from the HO-depleted organic solution to obtain a HO-containing aqueous solution.2. The method of wherein the channeled device has at least one cross sectional dimension within the range of from about 50 microns to about 3 mm.3. The method of wherein the channeled device contains at least one inlet connecting one or more channels and an outlet connecting the channels claim 1 , for respectively introducing the organic solution and aqueous medium into the extraction device and for removing a two phase liquid mixture from the extraction device.4. The method of wherein the channeled device further contains at least one additional passageway adjacent to at least one extraction channel for effecting heat transfer and temperature control during the extraction process using a heat transfer fluid in said at least one additional passageway.5. The method of wherein the channeled device comprises layered sheets that contain an interconnected channel network.6. The method of wherein the separation of the aqueous medium containing extracted hydrogen peroxide from the HO-depleted organic solution is carried out in a liquid-liquid ...

ELECTROWETTING ON DIELECTRIC (EWOD) DEVICE TO PERFORM LIQUID-TO-LIQUID EXTRACTION (LLE) OF BIOMOLECULES AND SYSTEMS AND METHODS FOR USING THE EWOD DEVICE

A method and system for performing biomolecule extraction are provided that use liquid-to-liquid extraction (LLE) in combination with an electrowetting on dielectric (EWOD) device to provide a biomolecule extraction solution that has high extraction efficiency and that is less costly and easier to use than current state of the art methods and systems. The system and method are well suited for, but not limited to, extraction of DNA, RNA and protein molecules. 1. A system for extracting biomolecules comprising:an electrowetting on dielectric (EWOD) device configured to perform liquid-to-liquid extraction (LLE) of a biomolecule, the EWOD device comprising:a reservoir that dispenses a liquid one droplet containing a particular type of biomolecules to be extracted and a liquid two droplet;a mixing and extraction section that receives the liquid one droplet and the liquid two droplet and mixes the liquid one droplet and the liquid two droplet together in a predetermined manner to extract the particular type of biomolecules into the liquid two droplet; anda separation section that separates the liquid two droplet having the particular type of biomolecules therein from the liquid one droplet to complete at least one cycle of LLE.2. The system of claim 1 , wherein liquid two is an ionic liquid (IL).3. The system of claim 2 , further comprising:a concentration measurement system that analyzes the liquid two droplet after separation from the liquid one droplet and generates a concentration measurement signal indicative of a concentration of the particular type of biomolecules contained in the separated liquid two droplet.4. The system of claim 3 , wherein the concentration measurement system is disposed on the EWOD device.5. The system of claim 4 , wherein the concentration measurement system comprises:at least a first light source that generates light of a predetermined wavelength or wavelength range;at least a first optical detector that detects light passing through the ...

EXTRACTION AND SEPARATION METHOD

An extraction and separation method separating a specific component from a raw material fluid using an extraction device including plural stages of extraction units connected sequentially. The extraction and separation method includes: extracting the specific component into an extraction solvent having a difference in specific gravity with respect to that raw material fluid from the raw material fluid while causing the raw material fluid and the extraction solvent to flow in a state of contact with each other in the extraction units for each stage; introducing at least part of the fluid discharged from an extraction unit to the next stage extraction unit in a state wherein the raw material fluid and the extraction solvent are mixed; and a final separation separating the raw material fluid, after the specific component has been extracted in the fluid discharged from the extraction unit in a final stage, and the extraction solvent that has extracted the specific component. 1. An extraction and separation method for extracting and separating a specific component from a raw material fluid , comprising:an extraction and separation step of extracting and separating the specific component from the raw material fluid, using an extraction device including a plurality of stages of extraction sections sequentially connected to one another,wherein the extraction and separation step includes:an extraction step of extracting the specific component from the raw material fluid to an extracting agent while the raw material fluid and the extracting agent having a specific gravity difference relative to the raw material fluid are allowed to flow in the extraction section at each stage while being in contact with each other;a feeding step of feeding at least a part of the fluid discharged from the extraction sections into the subsequent extraction sections while the raw material fluid and the extracting agent are mixed with each other; anda final separation step of separating the fluid ...

用于在不混溶流体之间进行扩散传递的方法与设备

在不混溶液体之间扩散传递诸如溶质之类的物质然后在不混合的情况下分离所说的液体的方法与设备：薄板的相反侧上具有第一和第二流路，它们用于传送第一和第二不混溶的流体，其中，薄板上开孔的高度不大于200微米，在各开孔内的流体之间会形成稳定的界面，在紧邻上述界面处有显著量的流体流。在上述界面的两端进行扩散传递，然后流体在不混合的情况下流离上述区域。所述流路按垂直于薄板测量时的宽度在10至500微米之间。各开孔的壁面可以是平行的或者是呈锥形的。

Monochlorotrifluoropropene compounds and compositions and methods using same

METHOD AND APPARATUS FOR DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS.

본 발명은 비혼화성 유체 사이의 용질과 같은 물질의 확산 전달 및 혼합 없이 액체의 후속 분리를 촉진시키기 위하여, 구멍(10)의 높이가 200μm 미만이고(시트의 폭 및 유체 흐름의 방향에 대해 수직으로 측정됨), 각각의 구멍내의 유체 사이의 경계면이 형성되고 경계면에 바로 인접한 위치에 다량의 유체 흐름가 있는, 소공성 시트(8)의 반대면상에 제1 및 제2비혼화성 유체를 운반시키는 제1 및 제2흐름 경로(1,2)를 갖는 장치 및 방법에 관한 것이다. 확산 전달은 경계면을 횡단하여 일어나고, 후속하여 유체는 혼합 없이 영역으로부터 유동한다. 시트(8)에 대해 수직으로 측정된 흐름 경로의 폭은 10 내지 500μm이다. 각각의 구멍의 벽은 평행하거나 점점 가늘어진 형태일 수 있다.

Process and apparatus for diffusion transfer between immiscible liquids

Microfabricated differential extraction device and method

This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers.

Microfabricated devices and methods

This invention provides microfabricated systems for extraction of desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing means allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers. Such diffusion-based mixing or sensing devices are preferably channel cell systems for detecting the presence and/or measuring the quantity of analyte particles in a sample stream.

Microfabricated differential extraction device and method

This invention provides a microfabricated extraction system and methods for extracting desired particles from a sample stream containing desired and undesired particles. The sample stream is placed in laminar flow contact with an extraction stream under conditions in which inertial effects are negligible. The contact between the two streams is maintained for a sufficient period of time to allow differential transport of the desired particles from the sample stream into the extraction stream. In a preferred embodiment the differential transport mechanism is diffusion. The extraction system of this invention coupled to a microfabricated diffusion-based mixing device and/or sensing device allows picoliter quantities of fluid to be processed or analyzed on devices no larger than silicon wafers.

Method and apparatus for diffusion transfer between immiscible fluids

Interaction system and interaction method

This interaction system comprises: an interaction part that has therein a process flow path through which a first fluid and a second fluid circulate such that the first fluid and the second fluid come in contact with each other and interact; a separation container that is connected to an outlet of the process flow path so as to receive a fluid mixture, which is a mixture of the first fluid and the second fluid, discharged from the outlet of the process flow path, and retains and separates the received fluid mixture into the first fluid and the second fluid; a first fluid supplying device that supplies the first fluid to an inlet of the process flow path; a second fluid pathway that links a separation container region in which the separated second fluid collects to an inlet of the process flow path so as to guide the separated second fluid within the separation container to said inlet of the process flow path; and a second fluid feeding pump that is provided to the second fluid pathway and feeds the separated second fluid within the separation container from the separation container to said inlet of the process flow path.

Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Device and method for real-time detection of aeropathogens

Monochlorotrifluoropropene compounds and compositions and methods using same

Various uses of monochlorotrifluoropropenes, in combination with one or more other components, including other fluoroalkenes, hydrocarbons; hydrofluorocarbons (HFCs), ethers, alcohols, aldehydes, ketones, methyl formate, formic acid, water, trans-1,2-dichloroethylene, carbon dioxide and combinations of any two or more of these, in a variety of applications, including as blowing agents, are disclosed.

Electrosynthesis of organic compounds

Disclosed is a process for the electrochemical transformation of a compound to form a product, the process comprising (i) effecting the transformation in the presence of an electrolyte comprising at least one room temperature ionic liquid, wherein the ionic liquid is air-stable and moisture-stable, (ii) recovering the product, and optionally (iii) recovering the ionic liquid. The process can be used to effect the electrochemical transformation of a wide range of organic compounds.

Method and apparatus for oil condition monitoring

Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams.

La presente invención se relaciona con un dispositivo, sistema y método para intercambiar componentes entre el primer y segundo fluidos por el contacto directo en un canal microfluidico. Los fluidos fluyen como capas delgadas en el canal. Uno de los fluidos se pasa a través de un filtro una vez que sale del canal y se recircula a través de un procesador secundario que cambia las propiedades del fluido. El fluido recirculado se reusa para el intercambio adicional. El filtro excluye las células sanguíneas del fluido recirculado y previene o limita la obstrucción del filtro. El procesador secundario remueve residuos metabólicos y agua por diafiltración.

Recovery of Aqueous Hydrogen Peroxide in Auto-Oxidation H2O2 Production

Hydrogen peroxide produced in an auto-oxidation process is recovered from H 2 O 2 -containing organic solution via liquid-liquid extraction with an aqueous medium in a device having elongated channels, with a small cross-sectional dimension, that facilitate efficient extraction of aqueous hydrogen peroxide from the organic solution.

Component movement processing method and component movement processing apparatus

Method and apparatus for diffusion transfer between immiscible fluids

(57)【要約】 不混和性流体間での溶質のような存在物の拡散移動及びその後の混合を伴わない流体の分離を促進させるために、有孔シートに向かい合って第１及び第２不混和性流体が流れる第１及び第２流路を有する方法及び装置であって、前記有孔シート内の開口部（１０）の高さが２００マイクロメートル以下（シートの幅方向及び流体流れの方向に対して垂直な方向で測定した場合）であり、安定な界面が各開口部内の流体間で形成され、有意の量の流体流れが界面に隣接する方法及び装置が開示される。拡散移動は界面を横切って起こり、その後、流体流れは混合することなくその領域から流出する。シート（８）に垂直な方向で測定される流路の幅は１０〜５００マイクロメートルである。各開口部の壁は平行であるか又はテーパがついている。

Extraction method using static micromixer

Monochloro trifluoro propene compound and the composition and method using it

公开了与一种或多种其它组分，包括其它氟代烯、烃；氢氟烃（HFC）、醚、醇、醛、酮、甲酸甲酯、甲酸、水、反式‑1,2‑二氯乙烯、二氧化碳和任何这些的两种或更多种的组合结合的单氯三氟丙烯在各种应用领域中的各种用途，包括作为发泡剂。

Emulsifying and separating device for liquid phases

A device for the emulsification and separation of small amounts of immiscible liquid phases has essentially a cover plate ( 2 ), which can be tightly connected to a base plate ( 1 ), where microchannels ( 4,4 a ,5,6,6 a ) in the form of grooves are cut out on the inner surface ( 3,3 a ) of the base plate ( 1 ) and/or cover plate ( 2 ). In a mixing zone, two microchannels ( 4,4 a ) run in a wave shape crossing one another a number of times. In a subsequent separation zone, they run essentially straight combined in a common microchannel ( 5 ). The otherwise tightly sealed-off microchannels ( 4,4 a ,5,6,6 a ) can be filled and emptied again via inlet apertures ( 8,8 a ) and outlet apertures ( 9,9 a ).

Method For Extracting At Least One Compound From A Liquid Phase Comprising A Functionalized Ionic Liquid, And Microfluidic System For Implementing Said Method

(EN) The invention concerns a method for extracting at least one chemical or biological compound from a liquid phase comprising at least one functionalized ionic liquid, via a liquid extracting fluid (F) which is miscible with said ionic liquid(s), and a microfluidic system ( 10 ) for implementing said method. The inventive extraction method includes moving, on one surface ( 12 ) of a microfluidic system ( 19 ), at least one microdrop ( 14 ) of said liquid phase into an extraction solution ( 20 ) which comprises said extracting fluid and which is localized on said surface to obtain in output of said solution, under the effect of an electric field, an extract (E) moving away from said surface which is rich in extracting fluid and enriched in said or at least one of said compound(s), and a raffinate (R) moving on said surface which is rich in ionic liquid(s) and deleted in said or one of said compound(s).

RECOVERY OF WATERPROOF HYDROGEN PEROXIDE IN THE PRODUCTION OF H2O2 BY AUTOXIDATION

El peróxido de hidrógeno producido en un proceso de autooxidación se recupera de la solución orgánica que contiene H2O2 por medio de la extracción líquido-líquido con un medio acuoso en un dispositivo que tienen canales alongados, con una dimensión transversal pequena, que facilita la extracción eficiente de peróxido de hidrógeno acuoso de la solución orgánica. The hydrogen peroxide produced in a self-oxidation process is recovered from the organic solution containing H2O2 by means of liquid-liquid extraction with an aqueous medium in a device that has long channels, with a small transverse dimension, which facilitates efficient extraction of aqueous hydrogen peroxide from the organic solution.

Extraction processes

A process for extracting a solute from an analyte-containing fluid phase. The process includes passing the analyte-containing fluid phase along a first fluid microchannel of a microfluidic extraction device and passing an extractant fluid phase that is at least partially immiscible with the analyte-containing fluid phase along a second fluid microchannel of the microfluidic extraction device. The analyte-containing fluid phase and the extractant fluid phase contact one another at a contact zone formed between the first and second fluid microchannels so that the solute is able to diffuse from the analyte-containing fluid phase into the extractant fluid phase. The analyte-containing fluid phase and/or the extractant fluid phase is a particle laden phase.

Systems and methods of microfluidic membraneless exchange using filtration of extraction outlet streams

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Extraction system

【課題】抽出システムの大型化及び構成の複雑化を抑制しつつ、原料液のｐＨが最適ｐＨに近い状態での抽出時間を増やして抽出効率を向上するとともに、抽出処理前の原料液の金属イオンの濃度の変化に柔軟に対応して抽出時間を適切に設定する。【解決手段】抽出システム１は、原料液槽４から導入された原料液と抽出液槽２から導入された抽出液とを互いに接触させることにより原料液から金属イオンを抽出して抽出液中へ移動させる抽出処理を行う抽出器６と、抽出処理後の原料液と抽出液との混合液を原料液と抽出液とに分離させる分離器１４と、分離器１４で分離された原料液を分離器１４から原料液槽４へ導く原料液戻し配管１８と、分離器１４で分離された抽出液を分離器１４から抽出液槽２へ導く抽出液戻し配管１６と、前記抽出処理により低下した原料液のｐＨを上昇させるｐＨ調整剤を原料液槽４内の原料液に添加する原料液ｐＨ調整剤添加装置１９と、を備える。【選択図】図１

Fine channel device, fine particle producing method and solvent extraction method

A fine channel device capable of producing fine particles in an industrial scale, hardening the fine particles immediately after the production and recovering the fine particles from a medium without collapsing the shape of the produced fine particles, a fine particle producing method using the fine channel device and a solvent extraction method using the fine channel, are presented. The fine channel device comprises a fine channel provided with an inlet port and an inlet channel which feed a dispersion phase, an inlet port and an inlet channel which feed a continuous phase, and an outlet channel and an outlet port which discharge fine particles produced by the dispersion phase and the continuous phase, wherein the inlet channel for feeding the dispersion phase and the inlet channel for feeding the continuous phase are joined at an arbitrary angle, and the two inlet channels are connected to the outlet channel at the arbitrary angle.

Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Electrowetting on dielectric (ewod) device to perform liquid-to-liquid extraction (lle) of biomolecules and systems and methods for using the ewod device

A method and system for performing biomolecule extraction are provided that use liquid-to-liquid extraction (LLE) in combination with an electrowetting on dielectric (EWOD) device to provide a biomolecule extraction solution that has high extraction efficiency and that is less costly and easier to use than current state of the art methods and systems. The system and method are well suited for, but not limited to, extraction of DNA, RNA and protein molecules.

Fine channel device, fine particle producing method and solvent extraction method

A fine channel device capable of producing fine particles in an industrial scale, hardening the fine particles immediately after the production and recovering the fine particles from a medium without collapsing the shape of the produced fine particles, a fine particle producing method using the fine channel device and a solvent extraction method using the fine channel, are presented. The fine channel device comprises a fine channel provided with an inlet port and an inlet channel which feed a dispersion phase, an inlet port and an inlet channel which feed a continuous phase, and an outlet channel and an outlet port which discharge fine particles produced by the dispersion phase and the continuous phase, wherein the inlet channel for feeding the dispersion phase and the inlet channel for feeding the continuous phase are joined at an arbitrary angle, and the two inlet channels are connected to the outlet channel at the arbitrary angle.

Solvent removing apparatus and method of manufacturing microsphere using the same

A solvent removing apparatus comprises: a tank body in which an emulsion comprising a first raw material in a continuous phase and a second raw material in a dispersed phase are contained; a fluid supplying part which supplies a fluid into the tank body to form flow in the emulsion; and a discharging part which discharges gas in the tank body to the outside of the tank. According to the present invention, extraction and evaporation of a solvent can be easily performed in a simple structure without a structure of an impeller or a stirrer.

Extraction and separation method

추출 분리 방법은, 원료 유체로부터 특정 성분을 추출하여 분리하는 방법이며, 순차 접속된 복수 단의 추출부를 구비한 추출 장치를 사용하여, 원료 유체로부터 상기 특정 성분을 추출하여 분리하는 추출 분리 공정을 구비하고, 상기 추출 분리 공정은, 각 단의 상기 추출부에 있어서 원료 유체와 그 원료 유체에 대해 비중 차를 갖는 추제를 서로 접촉시킨 상태에서 유통시키면서 원료 유체로부터 추제로 상기 특정 성분을 추출하는 추출 공정과, 상기 추출부로부터 배출되는 유체의 적어도 일부를 다음 단의 상기 추출부로 원료 유체와 추제가 혼합된 상태에서 도입하는 도입 공정과, 최종 단의 상기 추출부로부터 배출된 유체를 상기 특정 성분이 추출된 후의 원료 유체와 상기 특정 성분을 추출한 추제로 분리하는 최종 분리 공정을 갖는다. The extraction and separation method is a method of extracting and separating a specific component from a raw material fluid and includes an extraction and separation step of extracting and separating the specific component from the raw fluid using an extraction device having a plurality of extraction sections connected in sequence Wherein the extracting and separating step is an extraction step of extracting the specific component from the raw material fluid while circulating the raw material fluid in the extraction part at each stage in a state in which the raw material fluid and the starting material having a specific gravity difference are in contact with each other, An extraction step of introducing at least a part of the fluid discharged from the extraction unit into the extraction unit at the next stage in a state in which the raw material fluid and the trace are mixed with each other; And a final separation step of separating the raw material fluid after the extraction of the specific component into the extract.

Surfactant

A surfactant of formula (I) wherein A is a perfluoropolyether; L1 is CONR', wherein R' is selected from H and C1-6 alkyl; a is 0 or 1; b is 0 or an integer between 1 and 10; L2 is a linking group; c is 0 or 1; and X is a charged group.

Extraction separation method

提取分离方法是从原料流体中将特定成分提取并分离的方法，具备提取分离工序，在前述提取分离工序中，使用具备依次连接的多级的提取部的提取装置，从原料流体中将前述特定成分提取并分离，前述提取分离工序具有提取工序、导入工序、最终分离工序，在前述提取工序中，在各级的前述提取部中，一边使原料流体在与相对于该原料流体具有比重差的提取剂相互接触的状态下流通，一边从原料流体向提取剂提取前述特定成分，在前述导入工序中，将从前述提取部排出的流体的至少一部分以原料流体与提取剂混合的状态向下级的前述提取部导入，在前述最终分离工序中，将从最终级的前述提取部排出的流体分离为被提取前述特定成分后的原料流体和提取了前述特定成分的提取剂。

Device and method for placing immiscible fluid phases in contact with each other by means of centrifugal force

Method and apparatus for diffusion transfer between immiscible fluids

(57)【要約】 不混和性流体間の溶質のような存在物の拡散移動及びその後の混合を伴わない流体の分離を促進させるために、第１及び第２不混和性流体を保有し、流路が流体が互いに接触する界面領域（１６）で互いと連通して、安定な開放界面が形成される第１及び第２流体流路（１１、１２）を有する方法及び装置を開示する。拡散移動は界面を通して起こり、その後流体は混合することなく界面から流れ去る。界面に対して法線方向で測定される界面領域での流路の幅は、10〜500マイクロメートルである。

Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams

A device, system and method for exchanging components between first and second fluids by direct contact in a microfluidic channel. The fluids flow as thin layers in the channel. One of the fluids is passed through a filter upon exiting the channel and is recycled through a secondary processor which changes the fluid's properties. The recycled fluid is reused for further exchange. The filter excludes blood cells from the recycled fluid and prevents or limits clogging of the filter. The secondary processor removes metabolic waste and water by diafiltration.

Method for extracting at least one compound from a liquid phase comprising a functionalized ionic liquid, and microfluidic system for implementing said method

The invention concerns a method for extracting at least one chemical or biological compound from a liquid phase comprising at least one functionalized ionic liquid, via a liquid extracting fluid (F) which is miscible with said ionic liquid(s), and a microfluidic system (10) for implementing said method. The inventive extraction method includes moving, on one surface (12) of a microfluidic system (19), at least one microdrop (14) of said liquid phase into an extraction solution (20) which comprises said extracting fluid and which is localized on said surface to obtain in output of said solution, under the effect of an electric field, an extract (E) moving away from said surface which is rich in extracting fluid and enriched in said or at least one of said compound(s), and a raffinate (R) moving on said surface which is rich in ionic liquid(s) and deleted in said or one of said compound(s).

METHOD AND APPARATUS DIFFUSIVE TRANSFER BETWEEN IMMISCIBLE FLUIDS.

본 발명은 제1 및 제2의 비혼화성 유체들간의 공정을 수행하기 위한 방법 및 장치를 제공하는 것으로서, 본 발명의 장치는 제1 및 제2비혼화성 유체의 흐름을 허용하고 각각 자체들의 일부분이 서로 밀접 또는 근접하게 배치되어 안정한 개방 경게면을 형성하고 있는 영역에서 서로 개통-연결되어 있는 제1 및 제2흐름로를 구비하고 있으며, 상기 영역에서 상기 경계영역의 최소한 제1흐름로는 경계면에 대하여 수직으로 10 내지 500μm 범위에 해당되는 폭을 가진다.

Electrosynthesis of organic compounds

Disclosed is a process for the electrochemical transformation of a compound to form a product, the process comprising (i) effecting the transformation in the presence of an electrolyte comprising at least one room temperature ionic liquid, wherein the ionic liquid is air-stable and moisture-stable, (ii) recovering the product, and optionally (iii) recovering the ionic liquid. The process can be used to effect the electrochemical transformation of a wide range of organic compounds.

METHOD FOR EXTRACTION OF AT LEAST ONE CONNECTION FROM A LIQUID PHASE CONTAINING IONIC LIQUID, AND MICROFLUIDIC SYSTEM FOR IMPLEMENTING SAID METHOD

Method Of Working Up Liquid Substances

The invention concerns a method for preparing liquid substances, whereby the preparation is made in one or several micro-reactors and/or micro-mixers, the liquid substance to be prepared being continuously mixed with a washing liquid in the micro-reactors and/or micro-mixers.

Micromixing for high throughput microfluidic refining

The present disclosure relates to the design of structural features that enable the facile and reproducible fabrication of a microfluidic reactor that eliminates the problem of scaling factors in turn enabling the broad integration of microchannel reactors to industrial scale production. The process is highlighted via the effective and successful scale up of a purification process for the removal of a variety of different classes of impurities from crude vegetable oils mixtures into feedstocks that can be directly integrated into the hydrotreatment vegetable oil hydrogenation process for mass production of synthetic diesel derived from renewable sources.

Microfluidic chips and uses thereof

A microfluidic chip suitable for use in liquid-liquid or liquid-gas phase transfer applications is disclosed. The microfluidic chip comprises a contact zone comprising a high aspect ratio channel in fluid connection with at least one liquid or gas inlet whereby, in use, at least two immiscible or partially immiscible liquid and/or gas streams exiting the at least one liquid or gas inlet flow adjacent one another and in contact with one another through the contact zone under conditions to allow transfer of at least some of a chemical entity from one stream to the other before the streams exit the high aspect ratio channel at a microchip outlet.

Monochlorotrifluoropropene compounds and compositions and methods using same

Various uses of monochlorotrifluoropropenes, in combination with one or more other components, including other fluoroalkenes, hydrocarbons; hydrofluorocarbons (HFCs), ethers, alcohols, aldehydes, ketones, methyl formate, formic acid, water, trans-1,2-dichloroethylene, carbon dioxide and combinations of any two or more of these, in a variety of applications, including as blowing agents, are disclosed.

Micromixing for high throughput microfluidic refining

The present disclosure relates to the design of structural features that enable the facile and reproducible fabrication of a microfluidic reactor that eliminates the problem of scaling factors in turn enabling the broad integration of microchannel reactors to industrial scale production. The process is highlighted via the effective and successful scale up of a purification process for the removal of a variety of different classes of impurities from crude vegetable oils mixtures into feedstocks that can be directly integrated into the hydrotreatment vegetable oil hydrogenation process for mass production of synthetic diesel derived from renewable sources.

一种s型弯道微流控液滴萃取芯片及其制备方法

本发明公开了一种S型弯道微流控液滴萃取芯片，包括玻璃底板，玻璃底板内设有PDMS基板，PDMS基板的顶部一侧设有连续相入口和离散相入口，连续相入口与离散相入口的输出端连接有S型弯道，S型弯道的输出端设有检测区域，检测区域的输出端连接有直线通道，直线通道的输出端设有液体出口。一种S型弯道微流控液滴萃取芯片的制备方法，其特征在于：包括以下步骤：S1：掩模版制作；S2：阳模模具制作；S3：微流控芯片制作。本发明通过S型弯道式设计提高两相接触效率，实现对连续相中待测物的高效萃取，本发明对操作人员的要求低，自动化程度和稳定性较高，并提升了液滴萃取效率，有益于检测低浓度特征物检测。

Monoklorotrifluoropropenske spojine in sestavki ter postopki, ki jih uporabljajo

Compostos de monoclorotrifluoropropeno e composições e métodos utilizando os mesmos

目的成分の抽出方法、抽出装置、製造方法及び製造装置

Verfahren und vorichtung fur diffusionsaustausch zwischen nicht mischbare flüssigkeiten

Verfahren und vorrichtung für diffusionsaustausch zwischen nicht mischbare flüssigkeiten

Micromixing for high throughput microfluidic refining

The present disclosure relates to the design of structural features that enable the facile and reproducible fabrication of a microfluidic reactor that eliminates the problem of scaling factors in turn enabling the broad integration of microchannel reactors to industrial scale production. The process is highlighted via the effective and successful scale up of a purification process for the removal of a variety of different classes of impurities from crude vegetable oils mixtures into feedstocks that can be directly integrated into the hydrotreatment vegetable oil hydrogenation process for mass production of synthetic diesel derived from renewable sources.

一种利用串联孔喉微通道在高相比下强化稀土钕离子萃取的方法

本发明公开了一种串联孔喉微通道在高相比下强化萃取稀土钕离子的方法，属于湿法冶金技术领域。首先将P507加入磺化煤油得到有机相，将稀土盐溶液作为水相，将有机相与水相按照相比1:20~1:200，以1005~1050μL/min的体积流量经过微通道进行常温萃取，最终获得稀土元素萃取相和萃余相。本发明利用所设计的微通道比表面积高、传质速率快等优点，在高相比（>10:1）下进行萃取实验，通过串联孔喉微通道优异的传质性能实现高效萃取稀土钕的目标，是一种安全、高效、低耗的方法。

Verfahren für membranlosen mikrofluidaustausch in einem h-filter und filterung der extraktionsflüssigkeitsausgangsströme

Monochlortrifluorpropen forbindelser og sammensætninger og metoder, der anvender dem

Systeme und verfahren für auf blut basierende therapien mit einer membranlosen mikrofluid- austauschvorrichtung

Monoklooritrifluoripropeeniyhdisteitä ja -koostumuksia ja niitä käyttäviä menetelmiä

多级萃取系统

本申请的实施例涉及利用溶剂萃取实现分离溶液的一般的物理或化学的方法或装置，具体涉及一种多级萃取系统，该系统可以用于包含金属离子的溶液进行分离，其包括：初始水相料液输送泵、n级萃取单元、初始萃取剂料液输送泵、n级分离单元。其中，初始水相料液输送泵用于将初始水相料液输送至第1级萃取单元；初始萃取剂料液输送泵用于将初始有机相料液输送至第1级萃取单元以及将初始萃取剂料液输送至第n级萃取单元；萃取单元用于对输入的料液进行萃取，并将萃取之后的溶液输入到分离单元；分离单元用于对输入的溶液进行分离。本申请的实施例提供的系统可以实现单级高效萃取，可以提高萃取的纯度，减少萃取次数。

スラグ流の形成方法、有機化合物の製造方法、粒子の製造方法、及び抽出方法

Monochlorotrifluoropropene compounds and compositions and methods using same

Various uses of monochlorotrifluoropropenes, in combination with one or more other components, including other fluoroalkenes, hydrocarbons; hydrofluorocarbons (HFCs), ethers, alcohols, aldehydes, ketones, methyl formate, formic acid, water, trans-1,2-dichloroethylene, carbon dioxide and combinations of any two or more of these, in a variety of applications, including as blowing agents, are disclosed.

Plug flow system for identification and authentication of markers

Devices and methods for extraction, identification, authentication, and quantification of one or more covert markers in a material are disclosed. An extraction system includes a first plug flow mixer for mixing a first fluid bearing a marker and transfer agent into a plug flow. The mixing and flowing of the immiscible liquids causes transfer of the marker from the fluid to the transfer agent. A splitter having filters of different surface energies separates the two immiscible liquids, the transfer agent bearing the marker. A second plug flow can be used to transfer the marker to a second transfer agent. The transferred marker is detected to authenticate the original fluid. The marker can be further isolated, activated, or reacted to perform detection, identification or authentication. With the device, a number of independent processing and analytic steps are combined onto a single, portable unit.

Monochlorotrifluoropropene compounds and compositions and methods using same