14-03-2019 дата публикации
Номер: US20190076818A1
Принадлежит:
Material complexes that capture biologicals and methods of synthesizing and using such complexes composed of fluid-insoluble material and a receptor are provided herewith. The fluid-insoluble material has reactive functionality on its surface, including hydroxyl, amino, mercapto or eposy functionality material. The material can be agarose, sand, textile, or any combination thereof. The receptor is selected from the group consisting of mono-and poly-saccharides, heparin, or any combination thereof. Also provide are methods whereby releasing the captured biologicals and is controllable. 131-. (canceled)32. A method for separating a biological from a fluid sample comprising:mixing the fluid sample comprising the biological with a material complex comprising at least one hydroxyl-, amino-, mercapto or epoxy-containing material that is fluid-insoluble and at least one receptor selected from lactose, lactose derivative, mono- or poly-saccharide, heparin, chitosan, or any combination thereof, wherein the receptor is bound to the material via a linker;separating the biological from the fluid sample by immobilizing the biological to the material complex; andphysically separating the immobilized biological from the fluid sample by filtration, decantation, or a combination thereof while the biological remains immobilized to the material complex.33. The method of claim 32 , wherein the linker is a polymer comprising polyethylene glycol claim 32 , polyethylenimine claim 32 , polyvinylpyrrolidone claim 32 , acrylics claim 32 , acrylonitrile-butadiene-styrene claim 32 , polyacrylonitrile claim 32 , acetals claim 32 , polyphenylene oxides claim 32 , polyimides claim 32 , polystyrene claim 32 , polypropylene claim 32 , polyethylene claim 32 , polytetrafluoroethylene claim 32 , polyvinylidene fluoride claim 32 , polyvinyl chloride claim 32 , polyethylenimine claim 32 , polyesters claim 32 , polyethers claim 32 , polyamide claim 32 , polyorthoester claim 32 , polyanhydride claim 32 , ...
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