Anti dna antibody detection involving telomeric dna sequence recognition and binding
Номер патента: AU4721596A
Опубликовано: 18-09-1996
Автор(ы): Eeva-Marjatta Salonen
Принадлежит: EEVA MARJATTA SALONEN
Опубликовано: 18-09-1996
Автор(ы): Eeva-Marjatta Salonen
Принадлежит: EEVA MARJATTA SALONEN
Реферат: The invention relates to a diagnostic method for detection of anti-DNA antibodies in patients with lupus erythematosus, particularly SLE, test kit, solid phase means and a therapeutic method and a drug. All these applications are characterised by the use of telomeric DNA sequences able to bind specifically to anti-DNA-antibodies. Preferred antibody-binding telomeric sequences comprise 5'-TTAGGG-3', 5'-CCCTAA-3', repeats thereof or double stranded vertebrate telomere. Solid phase removal of anti-DNA antibodies with solid phase bound telomeric sequences and use of the telomeric sequences as a drug for treatment of patients with autoimmune disorders are revealed.
Deteccion de anticuerpos anti-dna que implica el reconocimiento y la union de secuencias telomericas de dna.
Номер патента: ES2175069T3. Автор: Eava-Marjatta Salonen. Владелец: Biohit Oy. Дата публикации: 2002-11-16.