Test systems for transporter proteins
Номер патента: EP2021461A2
Опубликовано: 11-02-2009
Автор(ы): Agnes Telbisz, Akos Pal, Andras Varadi, Attila Nemeth, Balazs Sarkadi, Dora Mehn, Emese Kis, Eva Fenyvesi, Eva Molnar, György Báthori, Hristos Glavinas, Lajos Szente, Peter Krajcsi, Szilvia Gedey, Tünde Nagy
Принадлежит: Solvo Biotechnologial Zrt
Опубликовано: 11-02-2009
Автор(ы): Agnes Telbisz, Akos Pal, Andras Varadi, Attila Nemeth, Balazs Sarkadi, Dora Mehn, Emese Kis, Eva Fenyvesi, Eva Molnar, György Báthori, Hristos Glavinas, Lajos Szente, Peter Krajcsi, Szilvia Gedey, Tünde Nagy
Принадлежит: Solvo Biotechnologial Zrt
Реферат: The invention provides for a novel cholesterol loaded insect cell membrane preparation having an increased cholesterol level as compared to physiological cholesterol levels of insect cell membranes or to control insect cell membrane preparations without cholesterol loading, wherein said cholesterol loaded membrane preparation comprises an ABC transporter protein having an increased substrate transport activity due to increased cholesterol level of the membrane. The invention also relates to reagent kits comprising the preparations of the invention. The invention also relates to methods for manufacturing said preparations and methods for measuring any type of activity of the ABC transporters present in the cholesterol loaded membranes as well as studying or testing compounds and interaction of compounds and ABC transporters, in this assay systems. The invention also provides for a test system useful for testing whether ABC transporter proteins can be activated by cholesterol in an insect cell membrane.
Cholesterol loaded insect cell membranes as test systems for abc transporter proteins
Номер патента: WO2007132279A3. Автор: Lajos Szente,Hristos Glavinas,Peter Krajcsi,Eva Fenyvesi,Attila Nemeth,Gyoergy Bathori,Dora Mehn,Akos Pal,Agnes Telbisz,Balazs Sarkadi,Andras Varadi,Szilvia Gedey,Emese Kis,Tuende Nagy,Eva Molnar. Владелец: Eva Molnar. Дата публикации: 2008-01-03.