Benzothiadiazepine compounds and their use as bile acid modulators
26-08-2021 дата публикации
Номер:
AU2020218908A1
Автор: GILLBERG PER-GÖRAN, MATTSSON JAN, STARKE INGEMAR, KULKARNI SANTOSH S, GILLBERG, Per-Göran, MATTSSON, Jan, STARKE, INGEMAR, KULKARNI, Santosh S.
Принадлежит: ALBIREO AB
Контакты:
Номер заявки: 89-21-202008
Дата заявки: 06-02-2020
The invention relates to 1,2,5-benzothiadiazepine derivatives of formula (I). These compounds are bile acid modulators having apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transport (LBAT) inhibitory activity. The invention also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds in the treatment of cardiovascular diseases, fatty acid metabolism and glucose utilization disorders, gastrointestinal diseases and liver diseases.