03-07-2014 дата публикации
Номер: US20140187819A1
Принадлежит:
A method for preparation of an aryl poly(oxalkyl) quaternary ammonium compound is provided, said method comprising steps of: 1) reacting a phenol with a dihalopolyalkylene ether under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) halide; 2) reacting said arylpoly(oxalkyl) halide with an amination reagent under the action of a phase transfer catalyst, to obtain an arylpoly(oxalkyl) amine; 3) reacting said arylpoly(oxalkyl) amine with an alkylation reagent, to obtain an aryl poly(oxalkyl) quaternary ammonium compound; wherein Ris H or a Cto Calkyl group, located in the ortho, meta or para position; n is an integer of 2 to 6; Ris H or a Cto Calkyl group; Ris H or a Cto Calkyl group; Ris a Cto Calkyl group; Xis Br or Cl; X is Cl, Br, or I. The preparation method according to the present invention requires low temperature and low pressure, the reaction time is short, and an overall yield can reach 75%. The operation is simple, the cost is low, and the product can be separated easily and have a purity of pharmaceutical grade, thereby facilitating the large-scale production. 2. The method according to claim 1 , wherein Ris a Cto Calkyl group claim 1 , Ris a Cto Calkyl group claim 1 , Ris a C˜Calkyl group.3. The method according to or claim 1 , wherein said phenol is one of phenol claim 1 , cresol claim 1 , 5-methyl-2-isopropyl phenol claim 1 , 2-methyl-5-isopropyl phenol claim 1 , p-tert-butyl phenol claim 1 , p-sec-butyl phenol claim 1 , p-tert-pentyl cresol claim 1 , p-sec-octyl phenol or p-tert-octyl phenol; and said dihalopolyalkylene ether is one of β claim 1 ,β′-dichloro diethyl ether claim 1 , β claim 1 ,β′-dichloro diisopropyl ether claim 1 , β claim 1 ,β′-dichloro dibutyl ether claim 1 , β claim 1 ,β′-dichloro dipentyl ether claim 1 , β claim 1 ,β′-dibromo diethyl ether claim 1 , β claim 1 ,β′-dibromo diisopropyl ether claim 1 , β claim 1 ,β′-dibromo dibutyl ether claim 1 , β claim 1 ,β′-dibromo dipentyl ether.4. The method according to ...
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