Quinoline and quinazoline compounds useful in therapy.

30-12-1998 дата публикации
Номер:
AP0000000715A
Принадлежит: Pfizer Res & Dev, Pfizer Central Res
Контакты:
Номер заявки: 00-00-1996900
Дата заявки: 19-12-1996

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The invention provides compounds of formula I. fluorine atoms; icier.. C1-6aikoxy and R1 represents C1-. alkoxy optionally substituted by one or —ore fluor R: represent H or C-6 alkax.y optionally substituted by one or more R3 represents one or more groups independently selected from H. h Cf; in addition. R: and one RJ srcup may together represent -OCH;-.the methylene group being attached to the ortho-position of the pendant phenyl ring; R4 represents a 4-, 5- or 6-membered heterocyciic ring containing selected from N, 0 and S, the ring being optionally fused to a benzene membered heterocyciic ring containing 1 or 2 hereroatoms selected ring system as a whole being optionally substituted; X represents CH or N; and L is absent or represents a cyclic group or an open chain group; and pharmaceuticaily acceptable salts thereof The compounds of formula I are useful in the treatment of inter alia prostatic hyperplasia