PYRIDINYL QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

02-11-2021 дата публикации
Номер:
CA2961811C
Контакты:
Номер заявки: 2961811
Дата заявки: 18-09-2015



ABSTRACT The invention relates to inhibitors of mutant isocitrate dehydrogenase (nt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: R6 1 1 A R4 R6 u ' I 1 R1 W2W12( N /N v-- Z , B 1 - H R2 W3 N ---......"0 FI3 (I). Date Recue/Date Received 2020-04-22