PHENYLALKYLAMINES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS

Compounds of general formula I ,(I) < IMG > wherein R1 represents a hydroxy group or an optionally substituted amino group; R2 and R3 each represents a halogen atom, a trifluoromethyl, cyano or nitro group or one of the radicals R2 or R3 represents a hydrogen atom; R4 represents a hydrogen atom or an alkyl group; R5 represents a hydrogen atom, an alkyl, cycloalkyl, alkenyl or aralkyl group; A represents a methylene, ethylene or hydroxymethylene group; and B represents an optionally substituted aralkyl group, whereby the methylene group adjacent to the phenyl nucleus, may be replaced by an oxygen or sulfur atom, or a sulfinyl or sulfonyl group; all optical isomers thereof, and mixtures of the aforesaid optical isomers; and acid addition salts thereof. Proceses for the preparation of the new compounds as well as pharmaceutical compositions containing them are also objects of this invention. The new compounds show valuable pharmacological properties, especially effects on the heart and circulation.