CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS
10-12-2020 дата публикации
Номер:
CA3140039A1
Автор: BANDARAGE UPUL KEERTHI, BLIGH CAVAN MCKEON, BOUCHER DIANE, BOYD MICHAEL JOHN, BRODNEY MICHAEL AARON, CLARK MICHAEL PHILIP, DAMAGNEZ VERONIQUE, FANNING LEV TYLER DEWEY, FIMOGNARI ROBERT FRANCIS, FLEMING GABRIELLE SIMONE, GAGNON KEVIN JAMES, GARCIA BARRANTES PEDRO MANUEL, GIACOMETTI ROBERT DANIEL, GIROUX SIMON, GREY JR RONALD LEE, GUIDO SAMANTHA, HALL AMY BETH, HOOD SARAH CAROL, HURLEY DENNIS JAMES, JOHNSON JR, JONES PETER, KESAVAN SARATHY, LAI MEI-HSIU, LIU SIYING, LOOKER ADAM, MAXWELL BRAD, MAXWELL JOHN PATRICK, MEDEK ALES, NUHANT PHILIPPE MARCEL, OVERHOFF KIRK ALAN, RODAY SETU, ROEPER STEFANIE, RONKIN STEVEN M, SAWANT RUPA, SHI YI, SHRESTHA MUNA, SPOSATO MARISA, STAVROPOULOS KATHY, SWETT REBECCA JANE, Tang Qing, TAPLEY TIMOTHY LEWIS, THOMSON STEPHEN, XU JINWANG, ZAKY MARIAM, COTTRELL KEVIN MICHAEL, BANDARAGE, UPUL KEERTHI, BLIGH, CAVAN MCKEON, BOUCHER, DIANE, BOYD, MICHAEL JOHN, BRODNEY, MICHAEL AARON, CLARK, MICHAEL PHILIP, DAMAGNEZ, VERONIQUE, Fanning, Lev Tyler Dewey, FIMOGNARI, ROBERT FRANCIS, FLEMING, GABRIELLE SIMONE, GAGNON, KEVIN JAMES, GARCIA BARRANTES, PEDRO MANUEL, GIACOMETTI, ROBERT DANIEL, Giroux, Simon, GREY Jr., Ronald Lee, GUIDO, SAMANTHA, HALL, AMY BETH, HOOD, SARAH CAROL, HURLEY, DENNIS JAMES, JOHNSON, JR., JONES, Peter, KESAVAN, SARATHY, LAI, MEI-HSIU, LIU, SIYING, LOOKER, ADAM, MAXWELL, BRAD, Maxwell, John Patrick, MEDEK, Ales, Nuhant, Philippe Marcel, OVERHOFF, KIRK ALAN, RODAY, SETU, Roeper, Stefanie, RONKIN, Steven M., SAWANT, RUPA, SHI, Yi, SHRESTHA, MUNA, SPOSATO, MARISA, STAVROPOULOS, KATHY, SWETT, REBECCA JANE, TANG, QING, TAPLEY, TIMOTHY LEWIS, THOMSON, STEPHEN, Xu, Jinwang, ZAKY, MARIAM, Cottrell, Kevin Michael
Принадлежит: Vertex Pharmaceuticals Inc
Контакты:
Номер заявки: 3140039
Дата заявки: 14-05-2020
The disclosure provides compounds useful for treating alpha-1 antitrypsin deficiency (AATD), according to formula (I), tautomers thereof, pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable salts of the tautomers, deuterated derivatives of the compounds, deuterated derivatives of the tautomers, and deuterated derivatives of the salts, solid forms of those compounds and processes for making those compounds.