Intermediates for the preparation of aminoalkylbenzene derivatives

30-05-1984 дата публикации
Номер:
CH0000643233A5
Принадлежит: ALLEN & HANBURYS LTD, ALLEN & HANBURYS LTD.
Контакты:
Номер заявки: 07-00-1982491
Дата заявки: 22-12-1982

[1]

1. Connections of the general formula II



[2]

As intermediates for the preparation of aminoalkylbenzene derivatives, compounds of the general formula II <IMAGE> in which the substituents attached to the benzene ring are in the ortho, para or meta position with respect to one another, and in which R1 and R2, which may be identical or different, represent hydrogen or lower alkyl, cycloalkyl, aralkyl or lower alkenyl groups, or lower alkyl groups which are interrupted by an oxygen atom or a group <IMAGE> in which R4 has the meaning hydrogen or lower alkyl, or R1 and R2 form, together with the nitrogen atom to which they are attached, a heterocyclic ring which may contain the hetero functions -O- and <IMAGE>, represents -O-, -S-, -CH2- or <IMAGE>, in which R5 has the meaning hydrogen or lower alkyl, m is an integer from 2 to 4, n has the value 0, 1 or 2 and Alk represents a straight-chain or branched alkylene chain having from 1 to 6 carbon atoms, and their acid addition salts with inorganic and organic acids.



1" Compounds eroism of the following general formula

NAlk.

R,

~ = Vr\

in which the substituents attached to the benzene ring are ortho, meta or para relative to each other, and R. j and which may be the same or different, are hydrogen atoms or lower alkyl, cycloalkyl, aralkyl or lower alkenyl or lower alkyl radicals interrupted by an oxygen atom or a group

- Noù represents a hydrogen atom or an alkyl radical

R4

lower, or R and R ^ ^ may form, with the nitrogen atom to which they are attached, a heterocyclic ring which may contain the hétérofonctions -0et-N-;

X is-O-, -S-, -CB ^-or- Noù R ^ is an atom

R5

hydrogen or a lower alkyl group;

m is an integer of value ranges from 2 to 4 inclusive;

n is O, 1 or 2 ; and

Alk denotes a straight or branched chain alkylene having 1 to 6 carbon atoms.

2, 3-(3-aminopropoxy)-K- diméthylbenzèneméthanamine according to claim 1



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