ANTIBACTERIAL CARBOXYLIC ACIDS AND PROCESS FOR THE PREPARATION THEREOF
[Title of the invention] Anti bacteria body The present disclosure since the gun disclosure recess not for communicating between multiple RF tags and specialized content 1-Alkyl-2-carboxy-7-substd.-1,4-dihydro-4-oxo-quinolines of formula (I) and their acid addn. salts are prepared. In (I), Z is alkyl, hydroxyalkyl, cycloalkyl, pyrolidinyl, piperidinyl, pyrimidyl or thiazolyl; X is CH, CCl, CF, C-OH, Co-alkyl or C-NH-alkyl; Y is H, F, Cl or Br; R1 is H, C1-6 alkyl or a cation; R2 is C1-4 alkyl, vinyl, halo alkyl, C2-4 hydroxyalkyl or C3-6 cycloalkyl. (I) are useful as broad spectrum antibacterials. And are reacted in a an amine formula Publicly known method of required to steer the pharmaceutically acceptable acid addition salts by least one flexible blocking arm or base salt resultant product is subjected thereby it is possible for conversion, manufacturing method of formula X the CH, CCl, CF, C-OH, 1-3 carbon atoms CO-alkyl, 1-3 carbon atoms N-alkyl or C-NH. Y hydrogen, fluorine, chlorine, bromine. The n 1, 2, 3, 4 and, n ' the 1, 2, 3, 4, is. (Wherein n+n ' is the 2, 3, 4 or 5) N "the 0, 1, 2, and, n" ' is the 1 or 2. R1 hydrogen, 1-6 alkyl carbon atoms, or cation is. R2 the 1-4 alkyl carbon atoms, vinyl, haloalkyl, 2-4 carbon atoms a hydroxy alkyl or cycloalkyl carbon atoms 3-6, R3 hydrogen, 1-4 alkyl carbon atoms, cycloalkyl carbon atoms 3-6, R4 hydrogen, alkyl carbon atoms 1-4, 1-4 carbon atoms hydroxyalkyl trifluoro ethyl or R7 CO-) wherein R7 N and Z is the X is N+n when ' the 3 and R3 is 3-6 or cycloalkyl carbon atoms 1-4 alkyl carbon atoms, R4 the 1-4 alkyl carbon atoms, 2-4 carbon atoms a hydroxy alkyl or trifluoro ethyl of under conditions that, 1-4 alkyl carbon atoms or an alkoxy carbon atoms 1-4. sheet.) R5 hydrogen or 1-3 alkyl carbon atoms. R6 hydrogen or 1-3 alkyl carbon atoms. X is C-OH C-OH of said hydrogen and of said when N-R2 of R2 following the next, pill ([...]) former Wherein, R8 1-3 is hydrogen or is an alkyl group having carbon atoms and, R9 hydrogen or 1-3. is an alkyl group having carbon atoms. A and a pharmaceutically acceptable stage cost for facility, expression vector for manufacturing acid adducts can be replaced by. Title Formula both before and Publicly known method of required to steer the pharmaceutically acceptable acid addition salts by least one flexible blocking arm or base salt resultant product is subjected for conversion elements selected from the consists in manufacturing method. Formula, [X, Y, R1, R2, R3, R4, R5, n " .anti as the number 1] Title Formula [Formula, n " the 1 or 2, a halogen Hal] both before and, halogenation a result title general formula atoms R3 R4 N-or azide of ions is reduced to settle the unbalance replaced by producing plated object using the plating bath, Resulting azide group R3 and R4 a compound is hydrogen amino group if necessary reducing the 1-3 carbon atoms and alkylated alkyl halide, if necessary, resulting product of a publicly known method by pharmaceutically acceptable acid addition salts for converting or base least one flexible blocking arm which consists in: elements selected from the manufacturing method. [Formula, X, Y, R1, R2, R3, R4, R5, n " anti as the number 1] Title With thioamide of formula Publicly known method by of required to steer the pharmaceutically acceptable acid addition salts or base salt least one flexible blocking arm consists in for conversion resultant product is subjected by formula of manufacturing method. [Formula, X, Y, R1, R2, R3, R4, R5, n " .anti as the number 1] Title With thioamide of formula Publicly known method by of required to steer the pharmaceutically acceptable acid addition salts or base salt least one flexible blocking arm consists in for conversion resultant product is subjected by formula of manufacturing method. [Formula, Y, R1, R3, R4, R5, R8, R9, n " .anti as the number 1] Title Formula amino [...] whereby reactions can take place Publicly known method by of required to steer the pharmaceutically acceptable acid addition salts or base salt least one flexible blocking arm consists in for conversion resultant product is subjected by formula of manufacturing method. [Formula, Y, R1, R3, R4, R5, R8, R9, n " .anti as the number 1] ※ reference particulars: initial application content by the drop of quality and reduction of disclosure.