Номер патента: GB1228851A
Опубликовано: 21-04-1971
Автор(ы):
Принадлежит:
Опубликовано: 21-04-1971
Автор(ы):
Принадлежит:
Реферат: 1,228,851. [3 - (N - Alkylacylamino) - 2,4,6- triiodophenoxy]-alkoxy alkane acids. BRACCO INDUSTRIA CHIMICA S.p.A. 7 May, 1968 [29 May, 1967], No. 21575/68. Heading C2C. The invention comprises compounds of the general Formula I in which "alkyl" represents an alkyl C 1-4 radical, "acyl" represents an aliphatic acyl C 2-4 radical derived from a carboxylic acid, "alkylene" represents an alkylene C 2-4 radical and R represents an alkyl C 1-4 or phenyl radical, or a non-toxic metal and/or amine salt thereof or an ester thereof with a lower C 1-5 alcohol. They are prepared by N-alkylating the corresponding (3- acylamino - 2,4,6 - triiodophenoxy) - alkoxy alkane acid in an alkaline medium with a reactive alkyl ester of a strong acid, or by reacting in the presence of a basic condensation agent the corresponding 3-(N-alkylacylamino)- 2,4,6-triiodophenol with a compound of the formula X-alkylene-OCHR.COOR<SP>1</SP>, in which X represents a reactive radical derived from a strong acid, COOR<SP>1</SP> represents a carboxylic ester or salt group and R and "alkylene" are as defined above, optionally hydrolysing the carboxylic ester group to obtain the free acid. 2 - (2<SP>1 </SP>- Chloroethoxy) - propionic acid ethyl ester is prepared by reacting the corresponding nitrile with hydrogen chloride. (N - Methylacetylamino) - phenol is prepared by reacting 3-methylamino phenol with acetic anhydride. α - (2 - Chloroethozy) - benzyl chloride is prepared by reacting benzaldehyde-bis-(2-chloroethyl)-acetal with thionyl chloride. α-(2-Chloroethoxy)-benzyl cyanide is prepared by reacting the corresponding chloride above with cuprous cyanide. 2 - [2<SP>1 </SP>- (3<SP>11</SP> - Acetylamino - 2<SP>11</SP>,4<SP>11</SP>,6<SP>11</SP> - triiodophenoxy)-ethoxy] propionic acid is prepared by the hydrolysis of the ethyl ester which is prepared from 3-acetylamino-2,4,6-triiodophenol and 2- (2<SP>1</SP>-chloroethoxy),propionic acid ethyl ester. Pharmaceutical compositions comprising compounds of Formula I as X-ray contrast agents together with a pharmaceutically acceptable carrier are administered orally and act as cholecystographic agents.
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Номер патента: RU0000000004U1. Автор: Селиванов Виктор Викторович. Владелец: Селиванов Виктор Викторович. Дата публикации: 1994-06-25.